Suvorexant: something new for sleep?

Orexin, also called hypocretin, is a neuropeptide that acts on central nervous system receptors to promote arousal. Suvorexant, its receptor antagonist, generates interest as a medication to treat insomnia. Suvorexant helps in decreasing wakefulness by counteracting orexin activity. Its low side effect potential may offer considerable benefit. Compared with other sleep aids, diminished drowsiness and less cognitive dysfunction is an advantage. Now approved for clinical use, an apparent lack of rebound insomnia or drug dependence potential might make suvorexant a good choice pharmacotherapy for patients with insomnia.

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Interleukin (IL) 1 , IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.94.1.227 ◽

1997 ◽

Vol 94 (1) ◽

pp. 227-232 ◽

Cited By ~ 162

Author(s):

M.-L. Wong ◽

P. B. Bongiorno ◽

V. Rettori ◽

S. M. McCann ◽

J. Licinio

Keyword(s):

Gene Expression ◽

Central Nervous System ◽

Nervous System ◽

Receptor Antagonist ◽

Systemic Inflammation ◽

Anterior Pituitary ◽

The Central Nervous System

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Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1986.tb10199.x ◽

1986 ◽

Vol 87 (3) ◽

pp. 569-578 ◽

Cited By ~ 53

Author(s):

E. Ann Brown ◽

R. Griffiths ◽

Carol A. Harvey ◽

D.A.A. Owen

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Receptor Antagonist ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Pharmacological Studies ◽

The Central Nervous System ◽

H1 Receptor Antagonist

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Pharmacokinetics and central nervous system effects of the novel dopamine D2 receptor antagonist JNJ-37822681

Journal of Psychopharmacology ◽

10.1177/0269881111415733 ◽

2011 ◽

Vol 26 (8) ◽

pp. 1119-1127 ◽

Cited By ~ 9

Author(s):

Erik T te Beek ◽

Matthijs Moerland ◽

Peter de Boer ◽

Luc van Nueten ◽

Marieke L de Kam ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Receptor Antagonist ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

The Novel ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

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Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

Pain ◽

10.1097/j.pain.0000000000000810 ◽

2017 ◽

Vol 158 (4) ◽

pp. 660-668 ◽

Cited By ~ 18

Author(s):

Carl I. Webster ◽

Jon Hatcher ◽

Matthew Burrell ◽

George Thom ◽

Peter Thornton ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Receptor Antagonist ◽

Transferrin Receptor ◽

Mechanical Hypersensitivity ◽

The Central Nervous System

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Chlorambucil-Induced Myoclonus in a Cat With Lymphoma

Journal of the American Animal Hospital Association ◽

10.5326/0390283 ◽

2003 ◽

Vol 39 (3) ◽

pp. 283-287 ◽

Cited By ~ 19

Author(s):

Noémi Benitah ◽

Louis-Philippe de Lorimier ◽

Michele Gaspar ◽

Barbara E. Kitchell

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Side Effect ◽

Alkylating Agent ◽

Laboratory Animals ◽

Intestinal Lymphoma ◽

Potential Side Effect ◽

Patient Reported ◽

Clonic Seizures

Chlorambucil is an alkylating agent commonly used in veterinary oncology for conditions including lymphoma. Chlorambucil neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil. This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity. Neurotoxicity should be considered a potential side effect of chlorambucil therapy in veterinary patients.

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Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret

Neuroscience Letters ◽

10.1016/j.neulet.2004.11.015 ◽

2005 ◽

Vol 376 (1) ◽

pp. 5-8 ◽

Cited By ~ 6

Author(s):

Andrew G. King ◽

Gareth J. Sanger

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Receptor Antagonist ◽

Neurokinin 3 Receptor

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Cognitive dysfunction, urinary retention, and a lesion in the thalamus—Beware of possible toxocariasis of the central nervous system

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2008.06.014 ◽

2008 ◽

Vol 110 (10) ◽

pp. 1054-1057 ◽

Cited By ~ 16

Author(s):

Rainer Scheid ◽

R. Tina Jentzsch ◽

Matthias L. Schroeter

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Urinary Retention ◽

Cognitive Dysfunction ◽

The Central Nervous System

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RYEGRASS STAGGERS: CLINICAL, PATHOLOGICAL AND AETIOLOGICAL ASPECTS

Proceedings of the New Zealand Grassland Association ◽

10.33584/jnzg.1983.44.1643 ◽

1983 ◽

pp. 230-233

Author(s):

P.H. Mortimer

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Close Association ◽

Clinical Signs ◽

Parasitic Fungus ◽

Animal Disease ◽

Paper Briefly ◽

Apparent Lack ◽

Biochemical Lesion ◽

The Central Nervous System

This paper briefly introduces animal disease aspects of ryegrass staggers IFiGS) and describes the occurence and the clinical signs of the disease. Recent suggestions for the production of a reversible biochemical lesion in the central nervous system are mentioned in relation to the apparent lack of specific morphological lesions found in sheep. The recent isolation of novel potent neurotoxins, the lolitrems, from toxic pasture material is reviewed. There is now strong circumstantial evidence that the lolitrems produce the neurotoxic disease of RGS and also that the lolitrems are elaborated in the close association of perennial ryegrass with its parasitic fungus, Lolium endophyte, in pastures. Under what conditions the lolitrems are produced, or their precise locus within the association, are not yet known.

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