scholarly journals A PILOT STUDY FOR THE VALIDATION OF SENTINEL LYMPH NODE BIOPSY WITH INDOCYANINE GREEN FLUORESCENCE METHOD IN EARLY ENDOMETRIAL CANCER AT FUNDACIÓN JIMÉNEZ DÍAZ UNIVERSITY HOSPITAL

2020 ◽  
Author(s):  
Jose García Villayzan
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Pilot Study ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Node Biopsy ◽  
University Hospital ◽  
Green Fluorescence ◽  
Indocyanine Green Fluorescence ◽  
Node Biopsy

scholarly journals Indocyanine green fluorescence method for sentinel lymph node biopsy in breast cancer

2020 ◽  
Vol 43 (12) ◽  
pp. 1149-1153 ◽  
Author(s):  
Joseph Lin ◽  
Li-Sheng Lin ◽  
Dar-Ren Chen ◽  
Kuo-Juei Lin ◽  
Yu-Fen Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Indocyanine Green ◽  
Lymph Node Biopsy ◽  
Fluorescence Method ◽  
Green Fluorescence ◽  
Indocyanine Green Fluorescence ◽  
Node Biopsy

scholarly journals Real-time in situ navigation system with indocyanine green fluorescence for sentinel lymph node biopsy in patients with breast cancer

2020 ◽  
Author(s):  
Zhaorui Wang ◽  
Xiaowei Yang ◽  
Peng Liu ◽  
Chunguang Han ◽  
Yubo Pan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Indocyanine Green ◽  
Real Time ◽  
Lymph Node Biopsy ◽  
Green Fluorescence ◽  
Indocyanine Green Fluorescence ◽  
Node Biopsy

Abstract Background: The naked-eye invisibility of indocyanine green fluorescence limits the application of near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node biopsy (SLNB) in patients with breast cancer undergoing surgery. This study aims to evaluate the effectiveness and safety of a novel NIR system in visualizing indocyanine green fluorescence images in the surgical field and the application value of combined methylene blue (MB) and the novel NIR system in SLNB. Methods: Sixty patients with clinical node-negative breast cancer received indocyanine green (ICG) and MB as tracers. Two NIR system instruments, namely, lymphatic fluorescence imaging system (LFIS) designed by the University of Science and Technology of China and vascular imager by Langfang Mingde Medical Biotechnology Co., Ltd. (Langfang vascular imager), were used as navigation assistance to locate sentinel lymph nodes (SLNs). Excising the lymph nodes developed by both MB and ICG by two NIR systems or palpably suspicious as SLNs and undergoing rapid pathological examination. Results: Both instruments exhibited 95% (57/60) success for real-time lymphatic fluorescent images. A total of 186 SLNs were identified, of which two were pathologically confirmed as lacking any lymph node tissue. SLN identification rate was 100% (184/184) for MB plus LFIS and 86.96% (160/184) for MB alone. The average number of SLNs identified by LFIS combined with MB was 3 (range of 1–8), which was significantly higher than that by MB alone at 2 (range 1–7) (P<0.05). Conclusion: LFIS effectively detects SLNs in breast cancer, projects the fluorescence signals during surgery, and provides a continuous surgical navigation system without the need for a remote monitor. The ICG method navigated by combined LFIS and MB may be a promising alternative tracer for radioisotope in SLN mapping.

SENTINEL LYMPH NODE BIOPSY USING FLUORESCENT LYMPHOGRAPHY IN CT1-4N0M0 BREAST CANCER PATIENTS: HIGH DIAGNOSTIC CAPABILITIES

2019 ◽  
Vol 65 (2) ◽  
pp. 243-249 ◽  
Author(s):  
Sergey Portnoy ◽  
A. Kuznetsov ◽  
N. Shakirova ◽  
Nikolay Kozlov ◽  
A. Maslyaev ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
False Negative ◽  
False Negative Rate ◽  
Lymph Node Biopsy ◽  
Green Fluorescence ◽  
Indocyanine Green Fluorescence ◽  
Node Biopsy

Breast cancer cT1-4N0M0 patients usually require a sentinel lymph node biopsy. Sentinel lymph node biopsy with indocyanine green fluorescence detection is a modern technique with a high lymph node detection rate. However, the false-negative rate was not evaluated adequately. Our objective was to determine node detection rate and the false-negative rate. 99 patients with 100 cases of breast cancer cT1-4N0M0 were operated on. The axillary part of an operation consisted of indocyanine green fluorescence-guided SLN biopsy and an axillary lymphadenectomy of levels I-II or I-П-Ш. A signal lymph node was detected in 98 cases (98 %). In 28 (28.6%) cases out of 98, metastases in signal lymph nodes were found. Other than sentinel lymph node had metastatic lesion only in 35.7% in SLN N+ cases. False negative result occurred in 1 case of 28 (3.6%). The application of indocyanine green fluorescence-guided sentinel lymph node biopsy in cN0 breast cancer patients allows for a high signal lymph node detection rate and a low false negative rate.

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