The prevalence of head and neck cancers continues to increase throughout the world, the modality of their management mainly includes surgery, radiotherapy (RTH), and chemotherapy and antiresorptive treatment.The complications of radiotherapy imperatively require concerted management and rigorous monitoring. Indeed, collaboration with the multidisciplinary team is essential and guarantees therapeutic success.The management of patients during and after these anticancer treatments by the specialist in maxillofacial prosthesis essentially comprises the treatment of early and late complications of radiotherapy, oral care and finally prosthetic rehabilitation depending on the case.The objective of this work is to describe the protocols and recommendations for the management of patients during and after radiotherapy and to highlight the role of the specialist in maxillofacial prosthodontics in this management.