Drug Guest Molecules as Modulators During One-Step Mechanochemical Encapsulation in MIL-100 (Fe) Framework
Keyword(s):
One Pot
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<p>We propose a facile one-pot mechanochemical strategy for the encapsulation of drug guest molecules (e.g. 5‑fluorouracil, caffeine, and aspirin) in MIL-100 (Fe) as the porous host framework. We reveal the modulating effect of 5-FU and caffeine, giving highly crystalline MIL‑100 (Fe), whereas aspirin led to the formation of an amorphous MOF phase. Inelastic neutron scattering (INS) was used to probe the intermolecular interactions underpinning the drug@MIL‑100 assemblies, where strong guest-host interaction was achieved <i>via</i> this eco-friendly approach.</p>
2020 ◽
Keyword(s):
1978 ◽
Vol 39
(8)
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pp. 899-904
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1978 ◽
Vol 39
(C6)
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pp. C6-918-C6-919
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1981 ◽
Vol 42
(C6)
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pp. C6-602-C6-604
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