Reducing the risk of chronic heart failure development in patients with arterial hypertension from the position of evidence medicine (focus on candesartan)

Arterial hypertension is the main risk factor for the development of cardiovascular complications and makes a significant contribution to cardiovascular morbidity, including chronic heart failure, and mortality, amounting to more than 45%. The leading risk factors for the development of cardiovascular diseases also include a violation of lipid and carbohydrate metabolism. Current treatments for cardiovascular disease include the administration of angiotensin II receptor blockers. This article provides an overview of the literature data on the efficacy, safety profile of candesartan, high adherence to this drug in patients with arterial hypertension, chronic heart failure, impaired carbohydrate and lipid metabolism. The advantages of candesartan in comparison with other representatives of this group of drugs in the prevention of chronic heart failure are emphasized according to large-scale international randomized trials. Keywords: arterial hypertension, atherosclerosis, diabetes mellitus, insulin resistance, chronic heart failure, candesartan, Hyposart For citation: Evdokimova AG, Stryuk RI, Evdokimov VV, Golikova AA. Reducing the risk of chronic heart failure development in patients with arterial hypertension from the position of evidence medicine (focus on candesartan). Consilium Medicum. 2021; 23 (1): 84–92. DOI: 10.26442/20751753.2021.1.200730

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Angiotensin II receptor blockers in the treatment of arterial hypertension in patients with concomitant pathology: focus on candesartan

Systemic Hypertension ◽

10.26442/sg29031 ◽

2014 ◽

Vol 11 (3) ◽

pp. 24-29

Author(s):

D I Trukhan

Keyword(s):

Diabetes Mellitus ◽

Heart Failure ◽

General Practitioner ◽

Angiotensin Ii ◽

Chronic Heart Failure ◽

Arterial Hypertension ◽

The Elderly ◽

Angiotensin Ii Receptor ◽

Receptor Blockers ◽

First Contact

The results of numerous foreign and russian researches allow us to consider Candesartan as an important component of an effective therapy for patients with arterial hypertension, including the elderly, as well as with concomitant chronic heart failure, diabetes mellitus and other disorders in practice cardiologist and doctor of first contact (the therapist and general practitioner).

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Organoprotecive effects of angiotensin II receptor blockers in patients with type 2 diabetes mellitus

Diabetes Mellitus ◽

10.14341/2072-0351-5675 ◽

2010 ◽

Vol 13 (2) ◽

pp. 58-61

Author(s):

Ivona Yanovna Yarek-Martynova ◽

Minara Shamkhalovna Shamkhalova

Keyword(s):

Angiotensin Ii ◽

Large Scale ◽

Protective Action ◽

Cardiovascular Complications ◽

Cardiac Insufficiency ◽

Angiotensin Ii Receptor ◽

Good Tolerability ◽

Depth Study ◽

Risk Patients ◽

Receptor Blockers

High prevalence of arterial hypertension and related cardiovascular complications dictates the necessity of preparations possessed of markedorganoprotective activity and good tolerability. The currently available data suggest advantages of iACE and ARB as preparations for the treatmentof cardiovascular diseases such as ability of iACE to improve clinical picture and outcome of therapy of cardiac insufficiency, left ventricle dysfunction,and myocardial infarction. Large-scale prospective studies demonstrated effectiveness of these agents in the treatment of CHD, stroke, diabetes, renalpathology and revealed their additional advantages attributable to inhibition of angiotensin II secretion other than those related to reduction of AP.These studies gave evidence of a more pronounced decrease in the frequency of cardiovascular events under effect of ARB in high-risk patients. However,protective action of ARB on the cardiovascular system compared with that of iACE and combination of ARB+iACE awaits an in-depth study.

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