scholarly journals "Pulsatile Vs Non-Pulsatile Intracranial Blood Flow: Animal Model of Blood Flow Restoration in Brain Tamponade"

2021 ◽  
Vol 39 (1) ◽  
Author(s):  
Bianchi F
Keyword(s):  
Animal Model ◽  
Blood Flow ◽  
Flow Restoration

scholarly journals Lipopolysaccharide decreases cochlear blood flow dose dependently in a guinea pig animal model via TNF signaling

2021 ◽  
Author(s):  
Friedrich Ihler ◽  
Saskia Freytag ◽  
Benedikt Kloos ◽  
Jennifer Lee Spiegel ◽  
Frank Haubner ◽  
...  
Keyword(s):  
Animal Model ◽  
Blood Flow ◽  
Guinea Pig ◽  
Cochlear Blood Flow ◽  
Pig Animal Model

THROMBOLYSIS BY TISSUE-PLASMNOCEN ACTIVATOR AND A FIBRIN (OCEN) -DEGRADATION PRODUCT, PEPTIDE 6A, IN A CANINE MDDEL OF ELECTRICALLY-INDUCED CORONARY THROMBOSIS

1987 ◽  
Author(s):  
T Saldeen ◽  
J Mehta ◽  
W Nichols ◽  
D Lew
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Thrombosis ◽  
Canine Model ◽  
Peak Effect ◽  
Endothelial Surface ◽  
Tissue Plasminogen ◽  
Flow Restoration ◽  
Mean Time ◽  
Stimulation Of

Intracoronary thrombus resulting in acute myocardial ischemia can be lysed by thrombolytic agents, such as, streptokinase or t-PA. We examined the potential of a recombitant tissue-plasminogen activator (rt-PA)and a fibrin (ogen)-degradation productpentapeptide 6A, Ala-Arg-Pro-Ala-Lys, corresponding to aminoacids 43-47 in the BB-chain of fibrinogen, which causes marked increase in coronary blood flow and stimulates prostacyclin release, in restoring coronary blood flow in dqgs with experimentally-induced thrombus. An occlusive thrombus was created in the circumflex (Cx) coronary artery in 8 dcgs by electricalstimulation of the endothelial surface. The electrically-induced Cx thrombus consisted primarily of platelets and fibrin. After the occlusive thrcmbus was stable without electrical currant, rt-PA (10ug/kg/minute for 30 minutes intravenously)or peptide 6A (5 unoles/minute for 20 minutes intracorcnary) were randomly administered. Infusion of t-PA restored coronar blood flow (peak 22 ±12 ml/minute, mean ±SD) in five of seven animlas. The time to flow restoration was 12.3 ± 9.1 minutes and the reflow persistedfor20.0 ± 10.9 minutes. Peptide 6A administration also restored coronary blood flow (peak 20 ± 4 ml/ minute) in seven of eight animals with occlusive coronary thrombus. Mean time to blood flow restoration (4.3 ±2.9 minutes) wasshorter(P>0.05) than with rt-PA, but thereflow persisted only for the duration of tine infusion (16.3 ± 10.2 minutes).Peptide 6A adninistration was associatedwith a significant (P±0.05) increase in plasma 6-keto-PGF1α indicating stimulation of prostacyclin release. In addition, plasma t-PA concentrations also increased (F>0.01) at the peak effect of peptide 6A indicating releaseof endogenous t-PA as another potentialmechanism of the thrombolytic effects of peptide 6A. This study demonstrates that peptide 6A exerts coronary thrombolytic effectsccmpa rable to those of t-PA in a canine model of coronary thrombosis.

A Conscious Animal Model for Studies of Coronary Collateral Blood Flow Dynamics

1990 ◽  
pp. 267-278 ◽  
Author(s):  
Dean Franklin ◽  
Atsushi Mikuniya ◽  
Masatoshi Fujita ◽  
Masaaki Takahashi ◽  
Michael McKown ◽  
...  
Keyword(s):  
Animal Model ◽  
Blood Flow ◽  
Flow Dynamics ◽  
Collateral Blood Flow ◽  
Coronary Collateral ◽  
Conscious Animal ◽  
Blood Flow Dynamics ◽  
Coronary Collateral Blood Flow

scholarly journals An animal model for the analysis of cochlear blood flow disturbance and hearing threshold in vivo

2009 ◽  
Vol 267 (2) ◽  
pp. 205-205
Author(s):  
Martin Canis ◽  
Warangkana Arpornchayanon ◽  
Catalina Messmer ◽  
Markus Suckfuell ◽  
Bernhard Olzowy ◽  
...  
Keyword(s):  
Animal Model ◽  
Blood Flow ◽  
Hearing Threshold ◽  
Flow Disturbance ◽  
Cochlear Blood Flow

scholarly journals Effect of Low-Frequency Therapeutic Ultrasound on Induction of Nitric Oxide in CKD: Potential to Prevent Acute Kidney Injury

2020 ◽  
Vol 6 (6) ◽  
pp. 453-460
Author(s):  
Michael W. Dae ◽  
Kathleen D. Liu ◽  
Richard J. Solomon ◽  
Dong W. Gao ◽  
Carol A. Stillson
Keyword(s):  
Nitric Oxide ◽  
Acute Kidney Injury ◽  
Animal Model ◽  
Blood Flow ◽  
Radionuclide Imaging ◽  
Therapeutic Ultrasound ◽  
Low Frequency ◽  
Kidney Injury ◽  
Large Animal Model ◽  
Large Animal

<b><i>Introduction:</i></b> Post-contrast acute kidney injury (PC-AKI) develops in a significant proportion of patients with CKD after invasive cardiology procedures and is strongly associated with adverse outcomes. <b><i>Objective:</i></b> We sought to determine whether increased intrarenal nitric oxide (NO) would prevent PC-AKI. <b><i>Methods:</i></b> To create a large animal model of CKD, we infused 250 micron particles into the renal arteries in 56 ± 8 kg pigs. We used a low-frequency therapeutic ultrasound device (LOTUS – 29 kHz, 0.4 W/cm<sup>2</sup>) to induce NO release. NO and laser Doppler probes were used to assess changes in NO content and blood flow. Glomerular filtration rate (GFR) was measured by technetium-diethylene-triamine-pentaacetic acid (Tc-99m-DTPA) radionuclide imaging. PC-AKI was induced by intravenous infusion of 7 cm<sup>3</sup>/kg diatrizoate. In patients with CKD, we measured GFR at baseline and during LOTUS using Tc-99m--DTPA radionuclide imaging. <b><i>Results:</i></b> In the pig model, CKD developed over 4 weeks (serum creatinine [Cr], mg/dL, 1.0 ± 0.2–2.6 ± 0.9, <i>p</i> &#x3c; 0.01, <i>n</i> = 12). NO and renal blood flow (RBF) increased in cortex and medulla during LOTUS. GFR increased 75 ± 24% (<i>p</i> = 0.016, <i>n</i> = 3). PC-AKI developed following diatrizoate i.v. infusion (Cr 2.6 ± 0.7 baseline to 3.4 ± 0.6 at 24 h, <i>p</i> &#x3c; 0.01, <i>n</i> = 3). LOTUS (starting 15 min prior to contrast and lasting for 90 min) prevented PC-AKI in the same animals 1 week later (Cr 2.5 ± 0.4 baseline to 2.6 ± 0.7 at 24 h, <i>p</i> = ns, <i>n</i> = 3). In patients with CKD (<i>n</i> = 10), there was an overall 25% increase in GFR in response to LOTUS (<i>p</i> &#x3c; 0.01). <b><i>Conclusions:</i></b> LOTUS increased intrarenal NO, RBF, and GFR and prevented PC-AKI in a large animal model of CKD, and significantly increased GFR in patients with CKD. This novel approach may provide a noninvasive nonpharmacological means to prevent PC-AKI in high-risk patients.

Role of Delayed Neuroglial Activation in Impaired Cerebral Blood Flow Restoration Following Comorbid Injury

2019 ◽  
Vol 40 (3) ◽  
pp. 369-380 ◽  
Author(s):  
Zareen Amtul ◽  
Jasmine Randhawa ◽  
Abdullah N. Najdat ◽  
David J. Hill ◽  
Edith J. Arany
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Restoration
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