Mitochondrial nitric oxide synthase

10.2741/2127 ◽  
2007 ◽  
Vol 12 (1) ◽  
pp. 1072 ◽  
Author(s):  
Pedram Ghafourifar
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mitochondrial Nitric Oxide Synthase ◽  
Oxide Synthase

Mitochondrial Nitric Oxide Synthase, Oxidative Stress and Apoptosis

Neurosignals ◽  
2001 ◽  
Vol 10 (1-2) ◽  
pp. 57-65 ◽  
Author(s):  
Pedram Ghafourifar ◽  
Urs Bringold ◽  
Sabine D. Klein ◽  
Christoph Richter
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mitochondrial Nitric Oxide Synthase ◽  
Oxide Synthase

scholarly journals Tamoxifen Induces Oxidative Stress and Mitochondrial Apoptosis via Stimulating Mitochondrial Nitric Oxide Synthase

2007 ◽  
Vol 67 (3) ◽  
pp. 1282-1290 ◽  
Author(s):  
Rafal R. Nazarewicz ◽  
Woineshet J. Zenebe ◽  
Arti Parihar ◽  
Sarah K. Larson ◽  
Enver Alidema ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mitochondrial Apoptosis ◽  
Mitochondrial Nitric Oxide Synthase ◽  
Oxide Synthase

Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine

2004 ◽  
Vol 430 (2) ◽  
pp. 170-177 ◽  
Author(s):  
Silvia Lores-Arnaiz ◽  
Gabriela D’Amico ◽  
Analía Czerniczyniec ◽  
Juanita Bustamante ◽  
Alberto Boveris
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mitochondrial Nitric Oxide Synthase ◽  
Oxide Synthase

scholarly journals Mitochondrial Nitric-oxide Synthase Stimulation Causes CytochromecRelease from Isolated Mitochondria

1999 ◽  
Vol 274 (44) ◽  
pp. 31185-31188 ◽  
Author(s):  
Pedram Ghafourifar ◽  
Ursula Schenk ◽  
Sabine D. Klein ◽  
Christoph Richter
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Isolated Mitochondria ◽  
Mitochondrial Nitric Oxide Synthase ◽  
Oxide Synthase

Mitochondrial nitric oxide synthase and its role in the mechanisms of cell adaptation to hypoxia

2016 ◽  
Vol 14 (2) ◽  
pp. 38-46 ◽  
Author(s):  
Vasiliy E Novikov ◽  
Olga S Levchenkova ◽  
Elena V Pozhilova
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Specific Protein ◽  
New Drugs ◽  
Adaptation To Hypoxia ◽  
Cell Adaptation ◽  
Protein Factor ◽  
Action Analysis ◽  
Mitochondrial Nitric Oxide Synthase ◽  
Oxide Synthase

Mitochondrial nitric oxide synthase (mtNOS) actively participates in mechanisms of regulation of cell adaptation to extreme factors. It is closely interacted with other mitochondrial regulatory factors and is involved in adaptation reactions of cells to hypoxia, ischemia and other pathogenic action. Analysis of the role of mtNOS in cell functioning in hypoxia condition and its influence on apoptosis is presented in the article. Complex mechanism of cell adaptation with participation of mitochondrial nitric oxide (NO) is considered. Mitochondrial NO is a modulator of cell respiration, synthesis of ATP, activity of mitochondrial ATP-sensitive potassium channels, mitochondrial megapore and the specific protein factor to hypoxia adaptation. The possibility of pharmacological regulation of mtNOS activity is discussed. This approach seems to be promising for searching of new drugs for the pharmacotherapy of diseases with hypoxia and ischemia in their pathogenesis. There is possible to regulate cell homeostasis, for example, resistance to hypoxia by modulating the activity of mtNOS and synthesis of mitochondrial NO.

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