Communicative sabotage, suicide and avoidance as evidences of communicative discomfort

Purpose of the study: The purpose of the article is to compare and distinguish between the communication phenomena of sabotage, suicide, and avoidance displayed in the speech of characters of modern Ukrainian plays; to define them as communicative tactics that do not always violate communicative comfort and lead to conflict in communication; to characterize the main communicative goals and maxims affected by these communicative tactics. The key methods of the study, in addition to general scientific ones, were such dedicated linguistic methods as contextual and situational, speech and action analysis of communicative sabotage, suicide, and avoidance, as well as the method of structural and pragmatic analysis to provide characteristics of speech abnormal behavior of characters in modern Ukrainian plays, to identify of the consequences of communicative sabotage, suicide, and avoidance. The tactics violating the rules of the communication code are communicative sabotage, communicative suicide, and communicative avoidance. Communicative sabotage is mainly used by characters in a negative psychoemotional state as a way to express irritation and contempt, which causes changes in the focus of communication and hinders the achievement of the objective, informative and communicative goals of communication.

Pre-clinical validation of an RNA-based precision oncology platform for patient-therapy alignment in a diverse set of human malignancies resistant to standard treatments

Predicting tumor sensitivity to antineoplastics remains an elusive challenge, with no methods demonstrating predictive power. Joint analysis of tumors-from patients with distinct malignancies who had progressed on multiple lines of therapy-and drug perturbation transcriptional profiles predicted sensitivity to 28 of 350 drugs, 26 of which (93%) were confirmed in low-passage, patient-derived xenograft (PDX) models. Drugs were prioritized based on their ability to either invert the activity of individual Master Regulator proteins, with available high-affinity inhibitors, or of the modules they comprise (Tumor-Checkpoints), based on de novo mechanism of action analysis. Of 138 PDX mice enrolled in 16 single and 18 multi-protein treatment arms, a disease control rate (DCR) of 68% and 91%, and an objective response rate (ORR) of 12% and 17%, were achieved respectively, compared to 6% and 0% in the negative controls arm, with multi-protein drugs achieving significantly more durable responses. Thus, these approaches may effectively complement and expand current precision oncology approaches, as also illustrated by a case study.

Wind Action Analysis on Different Structures of Photovoltaic Systems Installed on Flat Rooftops of Buildings

This paper aims to analyze the velocities and pressures that the wind exerts in three different configurations of photovoltaic systems installed on flat rooftops of buildings. The Finite Element Method is used to perform thirty computer simulations for different wind speeds and directions. From the obtained results analyzes of the maximum and minimum values of pressure and velocity on the surface of the structures and the building are performed. Thus, it is possible to identify the necessary precautions regarding materials and installation so that the structure is safe and does not result in accidents and material and economic damage.

Actions in Slow Motion: Theoretical and Methodological Reflections on Temporality in Actions and Intersubjective Understanding

This article examines the connection between actions, temporality, and media-based observation. Slow motion technology is currently being used especially in sports to examine and evaluate athletes’ actions more precisely in order to identify potential infringements of rules. Starting with a phenomenological perspective, this article engages in a critical assessment of the degree to which the intentions underlying athletes’ actions become clearer if their actions are slowed down using slow motion. It transpires that a more in-depth understanding is not possible because the process of time-stretching using media technology tends to obscure intersubjective understanding. Nevertheless, the use of different playback speeds does increase observers’ sensitivity to the temporality of action and observation. This is particularly the case when greater emphasis is placed on the body and its role in the formation and carrying out of intentions. With the phenomenological view and in special consideration of the body and the subjective intentionality, the paper contributes to a discussion about the connection of time and (inter-)action already led in ethnomethodology and conversation analysis. These findings mark a contribution to empirical social research as well, which is increasingly using video material in action analysis and should take slow motion as a possible augmented but also manipulated access to actions into account adequately. To this end, this article suggests a method for identifying the merits and demerits of using slow motion to analyse actions, and discusses the methodological implications of temporality in observation.

Morphoquantitative evaluation of the heart of equine athletes

The present work has as main objective to analyze the equine cardiac ventricles after death, from the morphoquantitative measurement. Six hearts of different races of horses with the presence or absence of different sports skills were used. The hearts were collected after the animal died and the cause of death was not stated. Six hearts of the equine species were analyzed, being 50% males and 50% females. As for the breed 33.3% was Quarter mile, 33.3% was Machador Broad Sleeve and 16.6% was Paulista Broad Sleeve and 16.6% was PSI. About athletic life, 50% were considered equine and the average weight of the animals was 426.83 kg, with the lowest weight 295 kg and the highest 560.0 kg. Regarding the dimensions of the hearts analyzed, the average weight of the ventricles was 2.71 kg, with the lowest weight 1.63 kg and the highest weight 3.83 kg; On the size of the base, it found an average of 22.28 cm, with the base smaller 17.0 cm and the largest base 25; As for the axis, the average was 25.66 cm, being the smallest of 22.0 cm and the largest of 30. Regarding the number of slices, case 1 was the smallest, being 9 and Case 2 and 5 presented a larger number of slices, being 12. Physical activity in horses seems to be associated with myocardial hypertrophy and this fact may increase the axis and allow greater cuts and action analysis.