scholarly journals Detection of new endemic focus of tick-borne encephalitis virus (TBEV), Hampshire/Dorset border, England, September 2019

2019 ◽  
Vol 24 (47) ◽  
Author(s):  
Maya Holding ◽  
Stuart D Dowall ◽  
Jolyon M Medlock ◽  
Daniel P Carter ◽  
Liz McGinley ◽  
...  
Keyword(s):  
United Kingdom ◽  
Viral Genome ◽  
Encephalitis Virus ◽  
Limited Area ◽  
Questing Tick ◽  
The United Kingdom ◽  
Endemic Focus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
New Location

The presence of tick-borne encephalitis virus (TBEV) was detected in a questing tick pool in southern England in September 2019. Hitherto, TBEV had only been detected in a limited area in eastern England. This southern English viral genome sequence is distinct from TBEV-UK, being most similar to TBEV-NL. The new location of TBEV presence highlights that the diagnosis of tick-borne encephalitis should be considered in encephalitic patients in areas of the United Kingdom outside eastern England.

scholarly journals Tick-Borne Encephalitis Virus, United Kingdom

2020 ◽  
Vol 26 (1) ◽  
pp. 90-96 ◽  
Author(s):  
Maya Holding ◽  
Stuart D. Dowall ◽  
Jolyon M. Medlock ◽  
Daniel P. Carter ◽  
Steven T. Pullan ◽  
...  
Keyword(s):  
United Kingdom ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

TBE in South Korea

2019 ◽  
Author(s):  
Joon Young Song
Keyword(s):  
South Korea ◽  
Human Case ◽  
Encephalitis Virus ◽  
Surveillance Studies ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

Although no human case of tick-borne encephalitis (TBE) has been documented in South Korea to date, surveillance studies have been conducted to evaluate the prevalence of tick-borne encephalitis virus (TBEV) in wild ticks.

TBE in Slovakia

2019 ◽  
Author(s):  
Jana Kerlik
Keyword(s):  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

The former Czechoslovak Republic was one of the first countries in Europe where the tick-borne encephalitis virus (TBEV) was identified.

Knowledge and vaccination practices among family physicians in northeastern France regarding tick-borne encephalitis virus.

2021 ◽  
pp. 101774
Author(s):  
Marie Dollat ◽  
Anne-Pauline Bellanger ◽  
Laurence Millon ◽  
Catherine Chirouze ◽  
Quentin Lepiller ◽  
...  
Keyword(s):  
Family Physicians ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Northeastern France ◽  
Tick Borne Encephalitis Virus

scholarly journals Computational and Rational Design of Single-Chain Antibody against Tick-Borne Encephalitis Virus for Modifying Its Specificity

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1494
Author(s):  
Ivan K. Baykov ◽  
Pavel Y. Desyukevich ◽  
Ekaterina E. Mikhaylova ◽  
Olga M. Kurchenko ◽  
Nina V. Tikunova
Keyword(s):  
Rational Design ◽  
Fold Increase ◽  
Encephalitis Virus ◽  
Chimeric Antibody ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Glycoprotein E ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

Tick-borne encephalitis virus (TBEV) causes 5−7 thousand cases of human meningitis and encephalitis annually. The neutralizing and protective antibody ch14D5 is a potential therapeutic agent. This antibody exhibits a high affinity for binding with the D3 domain of the glycoprotein E of the Far Eastern subtype of the virus, but a lower affinity for the D3 domains of the Siberian and European subtypes. In this study, a 2.2-fold increase in the affinity of single-chain antibody sc14D5 to D3 proteins of the Siberian and European subtypes of the virus was achieved using rational design and computational modeling. This improvement can be further enhanced in the case of the bivalent binding of the full-length chimeric antibody containing the identified mutation.

Sign in / Sign up

Export Citation Format

Share Document