scholarly journals The Effect of Intraarticular Triamcinolone Acetonide for Inflammation in Knee Osteoarthritis by Tc-99m HIG Scintigraphy

2021 ◽  
Vol 2 (2) ◽  
pp. 18-29
Author(s):  
İlknur Karlıbel ◽  
Munir Kerim Karakaya ◽  
Tayyar Akpinar
Keyword(s):  
Knee Osteoarthritis ◽  
Triamcinolone Acetonide

scholarly journals A randomized, phase IIa study to assess the systemic exposure of triamcinolone acetonide following injection of extended-release triamcinolone acetonide or traditional triamcinolone acetonide into both knees of patients with bilateral knee osteoarthritis

2019 ◽  
Vol 11 ◽  
pp. 1759720X1988130 ◽  
Author(s):  
Alan Kivitz ◽  
Louis Kwong ◽  
Tammi Shlotzhauer ◽  
Joelle Lufkin ◽  
Amy Cinar ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Triamcinolone Acetonide ◽  
Extended Release ◽  
Peak Plasma ◽  
Geometric Mean ◽  
Systemic Exposure ◽  
Pharmacokinetic Analysis ◽  
Bilateral Knee ◽  
American College Of Rheumatology ◽  
Crystalline Suspension

Background: Intra-articular corticosteroids are commonly used for pain relief in patients with knee osteoarthritis. Simultaneous intra-articular corticosteroid (CS) knee injections may be beneficial for the ~80–90% of patients who present with, or develop, bilateral knee osteoarthritis, but concurrent injections may increase systemic CS exposure and data on safety/tolerability are lacking. Triamcinolone acetonide extended release (TA-ER) has shown decreased systemic triamcinolone acetonide exposure compared with traditional triamcinolone acetonide crystalline suspension (TAcs) after a single knee injection in patients with knee osteoarthritis. This phase IIa study was designed to assess the safety and systemic triamcinolone acetonide exposure following injections of TA-ER or TAcs into each knee of patients with bilateral knee osteoarthritis. Methods: Patients (⩾40 years) meeting American College of Rheumatology criteria for knee osteoarthritis in both knees received concurrent single intra-articular injections of TA-ER 32 mg or TAcs 40 mg into each knee (total: 64 mg and 80 mg, respectively) and were followed for 6 weeks. Safety was evaluated based on treatment-emergent adverse events (TEAEs). Blood samples for pharmacokinetic analysis were collected pre-injection, and at the following postinjection time points: 1, 2, 3, 4, 5, 6, 8, 10, 12, and 24 h, and days 8, 15, 29, and 43. Results: Baseline characteristics were balanced between patients randomly assigned to TA-ER ( n = 12) or TAcs ( n = 12). Both treatments were well tolerated with comparable TEAE profiles. Peak plasma triamcinolone acetonide concentrations (Cmax) were lower following bilateral TA-ER injections [geometric mean, 2277.7 pg/ml (95% CI, 1602.13–3238.04)] compared with bilateral TAcs injections [7394.7 pg/ml (2201.06–24,843.43)], with median times to Cmax (Tmax) of 4.5 and 6.5 h, respectively. Conclusions: In patients with bilateral knee osteoarthritis, intra-articular injection of TA-ER into both knees was well tolerated. Consistent with pharmacokinetic profiles observed after a single knee injection, plasma triamcinolone acetonide concentrations were lower after bilateral TA-ER injections compared with the higher and more variable concentrations observed after bilateral TAcs injections. ClinicalTrials.gov identifier: NCT03378076

scholarly journals Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain

2018 ◽  
Vol 100 (8) ◽  
pp. 666-677 ◽  
Author(s):  
Philip G. Conaghan ◽  
David J. Hunter ◽  
Stanley B. Cohen ◽  
Virginia B. Kraus ◽  
Francis Berenbaum ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Triamcinolone Acetonide ◽  
Osteoarthritis Pain

scholarly journals Efficacy of Triamcinolone Acetonide Extended-Release in Participants with Unilateral Knee Osteoarthritis: A Post Hoc Analysis

2019 ◽  
Vol 36 (6) ◽  
pp. 1398-1411 ◽  
Author(s):  
Michael J. Langworthy ◽  
Philip G. Conaghan ◽  
Joseph J. Ruane ◽  
Alan J. Kivitz ◽  
Joelle Lufkin ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Triamcinolone Acetonide ◽  
Extended Release ◽  
Post Hoc Analysis ◽  
Post Hoc

scholarly journals FX006 prolongs the residency of triamcinolone acetonide in the synovial tissues of patients with knee osteoarthritis

2013 ◽  
Vol 21 ◽  
pp. S144-S145 ◽  
Author(s):  
N. Bodick ◽  
J. Lufkin ◽  
C. Willwerth ◽  
R.C. Blanks ◽  
C.A. Inderjeeth ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Triamcinolone Acetonide ◽  
Synovial Tissues

scholarly journals Clinical outcome of single intra articular injection of triamcinolone acetonide depot preparation on knee osteoarthritis

2018 ◽  
Vol 4 (4) ◽  
pp. 161-163
Author(s):  
Dr. Santosh Borkar ◽  
Dr. Swapnil Bhise ◽  
Dr. Sumit Raghute ◽  
Dr. Sidheshwar Thosar ◽  
Dr. Shrirang Godbole
Keyword(s):  
Clinical Outcome ◽  
Knee Osteoarthritis ◽  
Triamcinolone Acetonide

scholarly journals COMPARATIVE OF INTRAARTICULAR INJECTION BETWEEN DEXTROSE PROLOTHERAPY VERSUS TRIAMCINOLONE ACETONIDE IN KNEE OSTEOARTHRITIS

2020 ◽  
Vol 1 (2) ◽  
pp. 22-26
Author(s):  
Widodo Mardi Santoso ◽  
Andhy Indriyono ◽  
Badrul Munir ◽  
Alidha Nur Rakhman ◽  
Machlusil Husna
Keyword(s):  
Knee Osteoarthritis ◽  
Triamcinolone Acetonide ◽  
Intraarticular Injection
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