Establishment of Modified Chitosan Membrane For Wound Dressing Applications

The dynamic evolution of materials with medical applications, particularly for drug delivery and wound dressing applications, gives impetus to design new proposed materials, among which, hydrogels represent a promising, powerful tool. In this context, multifunctional hydrogels have been obtained from chemically modified chitosan and acrylic polymers as cross-linkers, followed by subsequent conjugation with arginine. The hydrogels were finely tuned considering the variation of the synthetic monomer and the preparation conditions. The advantage of using both natural and synthetic polymers allowed porous networks with superabsorbent behavior, associated with a non-Fickian swelling mechanism. The in vitro release profiles for ibuprofen and the corresponding kinetics were studied, and the results revealed a swelling-controlled release. The biodegradability studies in the presence of lysozyme, along with the hemostatic evaluation and the induced fibroblast and stem cell proliferation, have shown that the prepared hydrogels exhibit characteristics that make them suitable for local drug delivery and wound dressing.

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Preparation of polyvinyl alcohol/asiaticoside/chitosan membrane nano-composite using electrospinning technique for wound dressing

10.1063/5.0014545 ◽

2020 ◽

Author(s):

Arifin Budi Raharjo ◽

Richo Dwi Andika Putra ◽

Nanik Indayaningsih ◽

Yudi Srifiana ◽

Andri Hardiansyah ◽

...

Keyword(s):

Polyvinyl Alcohol ◽

Wound Dressing ◽

Electrospinning Technique ◽

Nano Composite ◽

Chitosan Membrane

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Synthesis, characterization, and evaluation of poly(aminoethyl) modified chitosan and its hydrogel used as antibacterial wound dressing

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2017.04.049 ◽

2017 ◽

Vol 102 ◽

pp. 457-467 ◽

Cited By ~ 16

Author(s):

Yubei Zhang ◽

Qifeng Dang ◽

Chengsheng Liu ◽

Jingquan Yan ◽

Dongsu Cha ◽

...

Keyword(s):

Wound Dressing ◽

Modified Chitosan

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Voltammetric Biosensor Based on a Modified Chitosan Membrane Enzyme Peroxidase

International Journal of Electrochemical Science ◽

10.20964/2016.12.64 ◽

2016 ◽

pp. 10391-10406 ◽

Cited By ~ 2

Author(s):

Pavla Martinkova ◽

Keyword(s):

Modified Chitosan ◽

Chitosan Membrane ◽

Membrane Enzyme

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Application of modified chitosan membrane for microbial fuel cell: Roles of proton carrier site and positive charge

Journal of Cleaner Production ◽

10.1016/j.jclepro.2016.06.153 ◽

2017 ◽

Vol 142 ◽

pp. 1274-1282 ◽

Cited By ~ 20

Author(s):

Penjit Srinophakun ◽

Anusith Thanapimmetha ◽

Sansaporn Plangsri ◽

Sutamart Vetchayakunchai ◽

Maythee Saisriyoot

Keyword(s):

Fuel Cell ◽

Microbial Fuel Cell ◽

Positive Charge ◽

Modified Chitosan ◽

Chitosan Membrane

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Preparation and in vivo evaluation of a novel gel-based wound dressing using arginine–alginate surface-modified chitosan nanofibers

Journal of Biomaterials Applications ◽

10.1177/0885328217739562 ◽

2017 ◽

Vol 32 (6) ◽

pp. 689-701 ◽

Cited By ~ 11

Author(s):

Mahsa Hoseinpour Najar ◽

Mohsen Minaiyan ◽

Azade Taheri

Keyword(s):

Wound Healing ◽

Wound Dressing ◽

Healing Process ◽

Wound Dressings ◽

Wound Healing Process ◽

In Vivo Evaluation ◽

Animal Group ◽

Modified Chitosan ◽

Surface Modified

The development of an effective wound dressing with the ability to induce skin wound healing is a great challenge in medicine. Nanofibers are highly attractive for wound dressing preparation due to their properties such as hemostasis induction, good absorption of wound exudates, and facilitation of cell growth. Chitosan nanofibers have attracted great attention for application in wound dressings due to their accelerating effects on wound healing. In this study, arginine surface-modified chitosan nanofibers were successfully prepared by attachment of arginine molecules on the surface of chitosan nanofibers using sodium alginate through electrostatic interaction. The effect of pH on the amount of attached arginine was evaluated at three different pH values; 5, 6, and 7. Fourier-transform infrared spectroscopy and zeta potential of chitosan nanofibers before and after surface modification suggested the occurrence of the attachment of arginine to chitosan nanofibers. Scanning electron microscope images showed the nanofibrous structure of arginine surface-modified chitosan nanofibers with an average diameter ranging from 100 nm to 150 nm. The release of arginine from arginine surface-modified chitosan nanofibers gel showed a sustained release manner. The suitable viscosity and spreadability of arginine surface-modified chitosan nanofibers gel verified its easy application at the wound site. Arginine surface-modified chitosan nanofibers gel significantly improved the wound healing process including wound closure when tested in vivo using rat model. Additionally, histological examination and immunohistochemical studies showed the significant enhancement of the re-epithelialization, collagen deposition, and angiogenesis in the skin of the animal group treated with arginine surface-modified chitosan nanofibers gel compared with the other control groups. These results suggested that arginine surface-modified chitosan nanofibers gel could be introduced as an effective wound dressing.

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