modified chitosan
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Polymers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 271
Author(s):  
Nouf F. Al-Harby ◽  
Ebtehal F. Albahly ◽  
Nadia A. Mohamed

Novel Uracil-modified chitosan (UCs) adsorbent has successfully been synthesized through a four-step method during which the amino groups of chitosan have been protected, then epoxy nuclei have been incorporated, afterwards the latter have been opened using 6-amino-1,3-dimethyl uracil, and finally the amino groups have been regained via removing the protection. Its structure was checked using FTIR, XRD and SEM techniques. The adsorption capacity of UCs for anionic Congo Red (CR) dye was studied under various conditions. It decreased significantly with increasing the solution pH value and dye concentration, while increased with increasing temperature. The adsorption of UCs for CR dye at different temperatures, solution pH and dye concentrations fitted to the kinetic model of pseudo-second order and Elovich model. The intraparticle diffusion model showed that the adsorption process involves multi-step process. The isotherm of CR dye adsorption by UCs conforms to the Langmuir isotherm model indicating the monolayer nature of adsorption. The maximum monolayer coverage capacity, qmax, was 434.78 mg g−1. Studying the thermodynamic showed that the adsorption of CR dye onto UCs was endothermic as illustrated from the positive value of enthalpy (21.37 kJ mol−1). According to the values of ΔG°, the adsorption process was spontaneous at all selected temperatures. The value of ΔS° showed an increase in randomness for the adsorption of CR dye by UCs. The value of activation energy was 18.40 kJ mol−1.


2022 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
sarah salem ◽  
El-Refaie Kenawy ◽  
Mohamed Abd AlRaheem Abu Saied ◽  
Ahmed Saafan

RSC Advances ◽  
2022 ◽  
Vol 12 (4) ◽  
pp. 1950-1960
Author(s):  
Zhi Chen ◽  
Jun Zeng ◽  
Zhi-Bo Zhang ◽  
Zhi-Jie Zhang ◽  
Shan Ma ◽  
...  

A kind of magnetic gel material was synthesized by cross-linking PEI modified chitosan and corncob biomass with good adsorption properties of heavy metal ions.


2022 ◽  
pp. 501-518
Author(s):  
M. Verónica Rivas ◽  
Adriana Kolender ◽  
Norma Beatriz D’Accorso

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 204
Author(s):  
Xiaoyi Gao ◽  
Nan Liu ◽  
Zengming Wang ◽  
Jing Gao ◽  
Hui Zhang ◽  
...  

Chitosan is a natural polysaccharide, mainly derived from the shell of marine organisms. At present, chitosan has been widely used in the field of biomedicine due to its special characteristics of low toxicity, biocompatibility, biodegradation and low immunogenicity. Chitosan nanoparticles can be easily prepared. Chitosan nanoparticles with positive charge can enhance the adhesion of antigens in nasal mucosa and promote its absorption, which is expected to be used for intranasal vaccine delivery. In this study, we prepared chitosan nanoparticles by a gelation method, and modified the chitosan nanoparticles with mannose by hybridization. Bovine serum albumin (BSA) was used as the model antigen for development of an intranasal vaccine. The preparation technology of the chitosan nanoparticle-based intranasal vaccine delivery system was optimized by design of experiment (DoE). The DoE results showed that mannose-modified chitosan nanoparticles (Man-BSA-CS-NPs) had high modification tolerance and the mean particle size and the surface charge with optimized Man-BSA-CS-NPs were 156 nm and +33.5 mV. FTIR and DSC results confirmed the presence of Man in Man-BSA-CS-NPs. The BSA released from Man-BSA-CS-NPs had no irreversible aggregation or degradation. In addition, the analysis of fluorescence spectroscopy of BSA confirmed an appropriate binding constant between CS and BSA in this study, which could improve the stability of BSA. The cell study in vitro demonstrated the low toxicity and biocompatibility of Man-BSA-CS-NPs. Confocal results showed that the Man-modified BSA-FITC-CS-NPs promote the endocytosis and internalization of BSA-FITC in DC2.4 cells. In vivo studies of mice, Man-BSA-CS-NPs intranasally immunized showed a significantly improvement of BSA-specific serum IgG response and the highest level of BSA-specific IgA expression in nasal lavage fluid. Overall, our study provides a promising method to modify BSA-loaded CS-NPs with mannose, which is worthy of further study.


2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Taghreed Abdalla ◽  
nadia Kandile ◽  
Abir Nasr ◽  
David Harding ◽  
Ghada Bassioni
Keyword(s):  

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
shimaa khaled ◽  
Howaida Zaky ◽  
Abeer Salah Nasr ◽  
nadia hassan

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