A case report on Meigs’ syndrome and elevated serum CA-125: A rare case report

Meigs syndrome is an uncommon presentation, where a benign ovarian neoplasia presents along with ascites and pleural effusion. About 1% of ovarian neoplasia can present as Meigs syndrome. Patients with Meigs’ syndrome and elevated serum CA-125 are not frequently reported. We report a case of a 50-year-old women who presented with shortness of breath, cough, weight loss of one and half month duration. Chest radiograph of the patient with clinical examination of patient confirms pleural effusion as cause of progressive shortness of breath. The presence of a pelvic mass and elevated serum CA-125, which raised the possibility of malignancy. After complete resection of tumor, the pathologic reports confirmed a benign ovarian neoplasia. We highlight the importance of suspicion, careful general examination, radiological assessment and histological tests to confirm the diagnosis of Meigs’ syndrome.

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Meigs' syndrome with elevated CA 125: case report

Sao Paulo Medical Journal ◽

10.1590/s1516-31802003000500007 ◽

2003 ◽

Vol 121 (5) ◽

pp. 210-212 ◽

Cited By ~ 10

Author(s):

Sabas Carlos Vieira ◽

Leonardo Halley Carvalho Pimentel ◽

José Carlos Castelo Branco Ribeiro ◽

Argemiro Ferreira de Andrade Neto ◽

Jerúsia Oliveira Ibiapina de Santana

Keyword(s):

Case Report ◽

Pleural Effusion ◽

Ovarian Tumor ◽

Frozen Section ◽

Transvaginal Ultrasound ◽

Elevated Serum ◽

Ca 125 ◽

Brazilian Woman ◽

Thoracic Drainage ◽

Benign Ovarian Tumor

CONTEXT: Meigs' syndrome consists of a benign ovarian tumor accompanied by ascites and hydrothorax. Elevated serum CA 125 levels in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor. However, patients with Meigs' syndrome can also have elevated serum CA 125 levels. The authors report a case of Meigs' syndrome with elevated CA 125 level. OBJECTIVE: This is a case report of Meigs' syndrome with elevated CA 125 level. CASE REPORT: A 65-year-old Brazilian woman had presented progressive dyspnea, weight loss and decline in general condition over the 7 months preceding admission to our service. In another hospital, the patient had been submitted to thoracic drainage due to pleural effusion. With recurrence of the pleural effusion and increase in abdominal volume due to ascites and a pelvic mass, the patient sought our service. Transvaginal ultrasound showed an extensive adnexal solid mass of 16.4 x 10.8 cm located in the pelvis without exact limits, and the serum CA 125 level was elevated. With a preoperative diagnosis of ovarian carcinoma, the patient was submitted to exploratory laparotomy, which revealed a left ovarian tumor. The frozen section diagnosis was thecoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The histology of the specimen confirmed the diagnosis of thecoma. The patient was asymptomatic with a normal serum CA 125 level 20 months after the operation.

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Sclerosing peritonitis associated with luteinized thecoma and elevated serum CA 125 levels: case report

Sao Paulo Medical Journal ◽

10.1590/s1516-31802008000200011 ◽

2008 ◽

Vol 126 (2) ◽

pp. 123-125 ◽

Cited By ~ 6

Author(s):

Sabas Carlos Vieira ◽

Lina Gomes dos Santos ◽

Felipe José da Silva Melo Cruz ◽

Wildson Moura Gonçalves ◽

Sheila de Farias Viana Castelo Branco Rocha

Keyword(s):

Case Report ◽

Elevated Serum ◽

Total Abdominal Hysterectomy ◽

Abdominal Hysterectomy ◽

Ca 125 ◽

Benign Tumors ◽

Histopathological Analysis ◽

Sclerosing Peritonitis ◽

Rare Case Report ◽

Peritoneal Biopsy

CONTEXT: Thecomas are benign tumors that account for less than 1% of all ovarian neoplasms. The association of ovarian thecoma with sclerosing peritonitis is rare. CASE REPORT: We report the case of a 33-year-old woman, with a two-month history of increasing abdominal volume. Ultrasound showed a complex pelvic lesion and laboratory analysis detected elevated serum CA 125 levels. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and peritoneal biopsy. Histopathological analysis revealed the presence of luteinized thecoma of both ovaries associated with sclerosing peritonitis.

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Struma Ovarii associated with Pseudo-Meigs Syndrome and elevated serum Ca 125: Case report and literature review

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20175490 ◽

2017 ◽

Vol 7 (1) ◽

pp. 336

Author(s):

Oyuki A. Morales ◽

Junior J. Araiza ◽

Tania P. Alvarez Dominguez ◽

Rafael Medrano Guzmán ◽

Jorge A. Barbabosa ◽

...

Keyword(s):

Case Report ◽

Pleural Effusion ◽

Thyroid Tissue ◽

Elevated Serum ◽

Rare Condition ◽

Definitive Diagnosis ◽

Ca 125 ◽

Struma Ovarii ◽

Axial Tomography ◽

Diagnostic Characteristics

Struma Ovarii is a highly specialized monodermal teratoma in which the major component is thyroid tissue. Its relationship with Pseudo Meigs syndrome, hyperthyroidism and elevation of Ca 125 is a rare condition; this could mimic malignancy. Ultrasound and axial tomography may be useful in diagnosis; but histopathological criteria play a very important role in the definitive diagnosis. Our objective is to present a case report of Struma ovarii, ascites, pleural effusion (pseudo meigs syndrome), elevation of Ca 125, hyperthyroidism, and review the published literature in relation to epidemiology and diagnostic characteristics.

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An Uncommon Presentation of Polycythemia Vera as Ischemic Stroke—A Rare Case Report

International Journal of Scientific Research ◽

10.15373/22778179/may2014/144 ◽

2012 ◽

Vol 3 (5) ◽

pp. 455-457

Author(s):

Dr .KOUSHIK GUDAVALLI ◽

◽

Dr .SHILPA CHIKATI ◽

Dr .MOHAN RAO JAKKAMPUTI ◽

Dr .KAMAL LOCHAN BEHERA ◽

...

Keyword(s):

Ischemic Stroke ◽

Case Report ◽

Polycythemia Vera ◽

Rare Case ◽

Uncommon Presentation ◽

Rare Case Report

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Rare case of perforated appendicitis presenting as persistent perineal discharge following laparoscopic abdominoperinal excision of rectum (APER)

BMJ Case Reports ◽

10.1136/bcr-2020-236312 ◽

2021 ◽

Vol 14 (1) ◽

pp. e236312

Author(s):

Tanmoy Mukherjee ◽

Shantata Jayant Kudchadkar ◽

Jayesh Sagar ◽

Shashank Gurjar

Keyword(s):

Case Report ◽

Rare Case ◽

Perforated Appendicitis ◽

Perineal Wound ◽

Abdominoperineal Excision ◽

Major Surgery ◽

Salvage Procedure ◽

Uncommon Presentation ◽

Rare Case Report ◽

History Of

Abdominoperineal excision of rectum (APER) is one of the widely used surgical procedures to treat low rectal cancer, benign conditions like Crohn’s proctitis with anal involvement and as a salvage procedure for anal cancer. Perineal wound infection is a well-recognised complication following such major surgery. Occurrence of appendicitis in a few weeks’ time following such a major surgery is uncommon. However, here we present a rare case report of perforated appendicitis presenting as persistent perineal discharge in an elderly man, following laparoscopic APER for a low rectal tumour. To our knowledge, this is the first time such a rare clinical presentation of appendicitis is reported in the history of medical literature. Through this case report, we aim to highlight the importance of considering such an uncommon presentation in patients with perineal discharge, following APER.

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