scholarly journals Regenerative Surgery & Intra-Operative Protocols Utilizing Bone Marrow Aspirate Concentrate in Microsurgical & Limb Reconstruction

2019 ◽  
Vol 2 (2) ◽  
pp. 39-46 ◽  
Author(s):  
Timothy J. Miller ◽  
Edgardo Rodriguez-Collazo ◽  
Stephen J. Frania ◽  
Alessandro Thione
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Limb Reconstruction ◽  
Bone Marrow Aspirate Concentrate

BONE MARROW ASPIRATE CONCENTRATE INJECTION OF THE ACHILLES TENDON IN A COMPETITIVE DISTANCE RUNNER

2021 ◽  
pp. 2140004
Author(s):  
Kathryn A. Farina ◽  
Blake A. Kandah ◽  
Nan M. Sowers ◽  
Gregory A. Moore
Keyword(s):  
Bone Marrow ◽  
Achilles Tendon ◽  
Bone Marrow Aspirate ◽  
Return To Sport ◽  
Distance Runner ◽  
Complication Rates ◽  
Bone Marrow Aspirate Concentrate ◽  
Progressive Return ◽  
Competitive Athletes ◽  
Lateral Margins

Achilles tendon disorders, including tendinopathy and ruptures, are common among competitive runners. Relatively high complication rates, recurring injuries, and the need to return to sport have led to the use of regenerative medical treatment in tendon disorders in competitive athletes. Biologic therapies, including bone marrow aspirate concentrate (BMAC) injections, have been effective in restoring injured tissue in a limited number of cases. In this case, a collegiate cross country runner with Achilles tendon pain underwent years of failed, non-surgical conservative management. The patient’s MRI demonstrated moderate distal calcaneus tendinosis with high-grade partial thickness tearing of the anterior fibers of the Achilles tendon (50% tear). The patient underwent peritendinous injection of BMAC. Post-procedure MRI demonstrated minimal tendinosis of the distal and lateral margins of the Achilles tendon, and no evidence of Achilles tendon tear. The patient followed a progressive return to running program, ultimately training 40 miles per week with minimal Achilles tendon pain.

scholarly journals Bone Marrow Aspirate Concentrate Is Equivalent to PRP for the Treatment of Knee OA at 1 Year: Letter to the Editor

2020 ◽  
Vol 8 (10) ◽  
pp. 232596712096070
Author(s):  
Gerard A. Malanga ◽  
Don Buford ◽  
William D. Murrell ◽  
Brian J. Shiple
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Bone Marrow Aspirate Concentrate ◽  
Knee Oa ◽  
Letter To The Editor

scholarly journals Autologous bone marrow aspirate concentrate (BMAC) for treatment of keratocystic odontogenic tumour (KCOT) —a case report

2021 ◽  
Vol 0 ◽  
pp. 0-0
Author(s):  
Manimaran Kanakaraj ◽  
Sangeetha Manoharan ◽  
Sivashankaran Srinivas ◽  
Marudhamani Chinnannan ◽  
Avinash Gandhi Devadas ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Bone Marrow Aspirate ◽  
Autologous Bone Marrow ◽  
Odontogenic Tumour ◽  
Bone Marrow Aspirate Concentrate ◽  
Autologous Bone ◽  
Keratocystic Odontogenic Tumour

scholarly journals BMAC and Adipose-Derived MSCs Treatment for Knee Osteoarthritis: A Systematic Review

2021 ◽  
Vol 7 (04) ◽  
pp. 01-11
Author(s):  
Pooja Pithadia
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Knee Osteoarthritis ◽  
Bone Marrow Aspirate ◽  
Stromal Vascular Fraction ◽  
Cochrane Library ◽  
Bone Marrow Aspirate Concentrate ◽  
Mesh Terms

Background: Knee osteoarthritis is the most common musculoskeletal progressive disorder that affects nearly 303 million people worldwide. This condition prevails in 10% males and 13% females among the elders above 60. Although there is conventional nonsurgical and surgical treatment available for knee osteoarthritis, there is a fascinating interest in bone marrow aspirate concentrate (BMAC) as well as adipose-derived mesenchymal stem cells (AD-MSC), including enzymatically treated stromal vascular fraction (SVF) and mechanically treated (microfat/nanofat) injections among physicians. Hence, this systematic review aims to determine the efficacy of BMAC and AD-MSCs (enzyme and mechanically treated) injections for knee osteoarthritis treatment. Methods: A systematic review was performed on the following data sources (PubMed, Scopus, Google Scholar, EMBASE, and Cochrane Library) published on March 31, 2021. The keywords or MeSH terms include 'Knee Osteoarthritis with 'Bone marrow aspirate concentrate' OR 'BMAC' or with 'Adipose-derived mesenchymal stem cells (AD-MSC)' or with 'Stromal vascular fraction' OR 'SVF' or 'Mechanically treated AD-MSC (mfat/nanofat)'. In addition, the retrieved articles were further reviewed to identify relevant research studies. Results: The authors reviewed and tabulated data based on the year of study, study type, therapy protocol, patient population, outcome measures, and interpretation. Among the 382 records screened, 43 studies (16 on BMAC and 27 on AD-MSCs) were included in the systematic review study. Among them, only 5 were randomized controlled trials. These selected studies demonstrated short-term positive outcomes such as improvement in knee pain and function with no adverse side effects. Moreover, researchers reported varied administration methods of BMAC or AD-MSC either as standalone or in combination with other conservative procedures such as PRP (Platelets Rich Plasma), HA (Hyaluronic acid), or surgery. Conclusions: BMAC and AD-MSC (enzymatically and mechanically treated) injections prove safer and more efficacious in patients with knee osteoarthritis for a shorter duration of 2 years. However, the available literature lacks high-quality studies with no varied clinical settings and long-term follow-up of more than two years.

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