scholarly journals Perspective: The Case Against Radioiodine Remnant Ablation in Patients with Well-Differentiated Thyroid Carcinoma

2008 ◽  
Vol 49 (8) ◽  
pp. 1395-1397 ◽  
Author(s):  
I. D. Hay ◽  
I. R. McDougall ◽  
J. C. Sisson
Keyword(s):  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Remnant Ablation ◽  
Well Differentiated ◽  
Radioiodine Remnant Ablation

scholarly journals Why radioiodine remnant ablation is right for most patients with differentiated thyroid carcinoma

2008 ◽  
Vol 36 (3) ◽  
pp. 343-346 ◽  
Author(s):  
Frederik A. Verburg ◽  
Markus Dietlein ◽  
Michael Lassmann ◽  
Markus Luster ◽  
Christoph Reiners
Keyword(s):  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Remnant Ablation ◽  
Radioiodine Remnant Ablation

scholarly journals Does undetectable basal Tg measured with a highly sensitive assay in the absence of antibodies and combined with normal ultrasonography ensure the absence of disease in patients treated for thyroid carcinoma?

2012 ◽  
Vol 56 (2) ◽  
pp. 149-151 ◽  
Author(s):  
Pedro Weslley Rosário ◽  
Augusto Flávio Campos Mineiro Filho
Keyword(s):  
Thyroid Carcinoma ◽  
Tumor Resection ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Whole Body ◽  
Sensitive Assay ◽  
Remnant Ablation ◽  
Highly Sensitive ◽  
Node Metastases ◽  
Well Differentiated

It has been proposed that, in patients treated for well-differentiated thyroid carcinoma, undetectable basal thyroglobulin (Tg) levels measured with a highly sensitive assay in the absence of anti-thyroglobulin antibodies (TgAb) and combined with negative neck ultrasonography (US) ensured the absence of disease. We report a series of five patients with well-differentiated (papillary) carcinoma submitted to total thyroidectomy with apparently complete tumor resection, followed by remnant ablation with 131I (100-150 mCi), who had no distant metastases upon initial post-therapy whole-body scanning. When tumor recurrence or persistence was detected, these patients presented undetectable basal Tg (0.1 ng/mL) in the absence of TgAb, and US showed no anomalies. Two patients had lymph node metastases, one had mediastinal metastases, bone involvement was observed in one patient, and local recurrence in one. We conclude that further studies are needed to define in which patients undetectable basal Tg (negative TgAb) combined with negative US is sufficient, and no additional tests are required.

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