Novel18F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of18F-LY2459989 in Nonhuman Primates

Effects of the δ-opioid receptor antagonist naltrindole on opioid induced in vivo release of corticosterone

European Journal of Pharmacology ◽

10.1016/0014-2999(90)93878-t ◽

1990 ◽

Vol 183 (6) ◽

pp. 2321-2322

Author(s):

I. Kitchen ◽

A. Kennedy

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

In Vivo Release ◽

Δ Opioid Receptor

Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

Neurogastroenterology & Motility ◽

10.1111/nmo.13563 ◽

2019 ◽

Vol 31 (5) ◽

pp. e13563 ◽

Cited By ~ 8

Author(s):

Toshiyuki Kanemasa ◽

Katsumi Koike ◽

Tohko Arai ◽

Hiroko Ono ◽

Narumi Horita ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

In Vivo Models ◽

Μ Opioid Receptor

Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in Vitro and in Vivo Opioid Receptor Antagonist Activity

Journal of Medicinal Chemistry ◽

10.1021/jm1004978 ◽

2010 ◽

Vol 53 (14) ◽

pp. 5290-5301 ◽

Cited By ~ 21

Author(s):

Scott P. Runyon ◽

Lawrence E. Brieaddy ◽

S. Wayne Mascarella ◽

James B. Thomas ◽

Hernán A. Navarro ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Antagonist Activity ◽

In vivo effects of μ-opioid receptor agonist/δ-opioid receptor antagonist peptidomimetics following acute and repeated administration

British Journal of Pharmacology ◽

10.1111/bph.14148 ◽

2018 ◽

Vol 175 (11) ◽

pp. 2013-2027 ◽

Cited By ~ 20

Author(s):

Jessica P Anand ◽

Kelsey E Kochan ◽

Anthony F Nastase ◽

Deanna Montgomery ◽

Nicholas W Griggs ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Repeated Administration ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor ◽

Δ Opioid Receptor ◽

In Vivo Effects

The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/s00210-013-0844-5 ◽

2013 ◽

Vol 386 (6) ◽

pp. 471-478 ◽

Cited By ~ 15

Author(s):

Scott R. Armstrong ◽

Christina B. Campbell ◽

Carrie L. Richardson ◽

Ross G. Vickery ◽

Pamela R. Tsuruda ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

The Novel ◽

Cns Activity

An In Vitro and In Vivo study of BNAP: A Novel Peripherally Selective μ‐opioid Receptor Antagonist

The FASEB Journal ◽

10.1096/fasebj.29.1_supplement.929.2 ◽

2015 ◽

Vol 29 (S1) ◽

Author(s):

D Williams ◽

Y Yuan ◽

D Stevens ◽

Y Zhang ◽

W Dewey ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

In Vivo Study ◽

Μ Opioid Receptor

Determination of the In Vivo Selectivity of a New -Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey

Journal of Nuclear Medicine ◽

10.2967/jnumed.112.118877 ◽

2013 ◽

Vol 54 (9) ◽

pp. 1668-1674 ◽

Cited By ~ 26

Author(s):

S. J. Kim ◽

M.-Q. Zheng ◽

N. Nabulsi ◽

D. Labaree ◽

J. Ropchan ◽

...

Keyword(s):

Rhesus Monkey ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Pet Tracer

Faculty Opinions recommendation of A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1119600.577817 ◽

2008 ◽

Author(s):

George Breese ◽

Mary Katherine Kelm

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Heavy Drinking ◽

Ethanol Consumption ◽

Delta Opioid Receptor ◽

Faculty Opinions recommendation of Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718110987.793483835 ◽

2013 ◽

Author(s):

Pamela Mellon ◽

Alexander Kauffman

Keyword(s):

Luteinizing Hormone ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Hormone Secretion ◽

Kappa Opioid Receptor ◽

Female Rats ◽

Luteinizing Hormone Secretion ◽

Kappa Opioid ◽

Puberty Onset

Faculty Opinions recommendation of The selective mu-opioid receptor antagonist ADL5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in MPTP-lesioned macaque model of Parkinson's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9987957.10722055 ◽

2011 ◽

Author(s):

Alfredo Berardelli ◽

Antonio Suppa

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Macaque Model ◽