scholarly journals TauIQ - A canonical image based algorithm to quantify tau PET scans

2021 ◽  
pp. jnumed.120.258962
Author(s):  
Alex Whittington ◽  
Roger Gunn
Keyword(s):  
Tau Pet ◽  
Pet Scans ◽  
Canonical Image

scholarly journals Longitudinal tau PET using [18F]flortaucipir: Comparison of (semi)quantitative parameters

2021 ◽  
Author(s):  
Denise Visser ◽  
Hayel Tuncel ◽  
Rik Ossenkoppele ◽  
Maqsood Yaqub ◽  
Emma E Wolters ◽  
...  
Keyword(s):  
Blood Flow ◽  
Specific Binding ◽  
Region Of Interest ◽  
Accurate Estimate ◽  
Subjective Cognitive Decline ◽  
Quantitative Pet ◽  
Flow Changes ◽  
Tau Pet ◽  
Pet Scans

Purpose: Semi-quantitative PET measures can be affected by changes in blood flow, whereas quantitative measures are not. The aim of the study was to compare semi-quantitative(SUVr) and quantitative(R1, BPND) parameters of longitudinal tau PET scans with [18F]flortaucipir, with respect to changes in blood flow. Methods: Subjects with subjective cognitive decline(SCD; n=38) and Alzheimer′s disease(AD) patients(n=24) underwent baseline(BL) and 2-year follow-up(FU) dynamic [18F]flortaucipir PET scans. BPND and R1 were estimated using RPM and SUVr(80-100min) was calculated (cerebellar gray as reference). For each region-of-interest ((trans)entorhinal, limbic and neocortical) and parameter, %change was calculated. Regional SUVrs were compared to corresponding DVR (= BPND+1) using paired T-tests. Additionally, simulations were performed to model effects of flow changes on BPND and SUVr in different binding categories. Thereafter, %bias for SUVr with respect to underlying binding and flow were evaluated. Results: In SCD, there was a difference between %change in the (trans)entorhinal ROI (DVR 2.56% vs SUVr 1.85%) only. In AD, a difference was found in the limbic ROI (DVR 6.61% vs SUVr 7.52%) only. R1 changes were small(+0.7% in SCD and -1.6% in AD). Simulations illustrated with increasing flow a decreased %bias for SUVr in low binding conditions, whereas a slightly increased bias was observed in high binding conditions. Conclusion: SUVr provided an accurate estimate of specific binding for [18F]flortaucipir over a two-year follow-up. However, simulations showed that flow changes can affect [18F]flortaucipir SUVr, hence DVR/BPND should be preferred in more advanced disease stages and/or conditions that could induce significant flow changes like pharmacotherapeutic interventions.

IC-P-184: Comparison of Early Dynamic Amyloid and TAU-PET Scans to 18 F-FDG-PET image

2016 ◽  
Vol 12 ◽  
pp. P134-P134
Author(s):  
Gareth R. Jones ◽  
Victor L. Villemagne ◽  
Tia L. Cummins ◽  
Christopher C. Rowe
Keyword(s):  
Fdg Pet ◽  
Tau Pet ◽  
Pet Scans

scholarly journals P4-282: MENTAL AND PHYSICAL ACTIVITY DURING THE 80-MINUTE UPTAKE TIME AFFECTS OFF-TARGET BINDING IN TAU PET SCANS (18F-FTP)

2019 ◽  
Vol 15 ◽  
pp. P1392-P1394
Author(s):  
Hoon-Ki Min ◽  
Christopher Apgar ◽  
Scott Nancy ◽  
Emily S. Lundt ◽  
Sabrina M. Albertson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Tau Pet ◽  
Target Binding ◽  
Pet Scans

scholarly journals IC-P-171: MENTAL AND PHYSICAL ACTIVITY DURING THE 80-MINUTE UPTAKE TIME AFFECTS OFF-TARGET BINDING IN TAU PET SCANS (18F-FTP)

2019 ◽  
Vol 15 ◽  
pp. P134-P135
Author(s):  
Hoon-Ki Min ◽  
Christopher Apgar ◽  
Scott Nancy ◽  
Emily S. Lundt ◽  
Sabrina M. Albertson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Tau Pet ◽  
Target Binding ◽  
Pet Scans

scholarly journals Medial temporal tau can be a predictor for amyloid-ß positivity in mild cognitive impairment

2020 ◽  
Author(s):  
Hanna Cho ◽  
Min Seok Baek ◽  
Hye Sun Lee ◽  
Jae Yong Choi ◽  
Jae Hoon Lee ◽  
...  
Keyword(s):  
Area Under The Curve ◽  
Standardized Uptake Value ◽  
Visual Assessment ◽  
Parahippocampal Cortex ◽  
Positron Emission ◽  
Auc Value ◽  
Tau Pet ◽  
Sensitivity Specificity ◽  
Post Hoc ◽  
Pet Scans

Abstract Introduction Although both amyloid-ß (Aß) and tau positron emission tomography (PET) are important for the assessment of Alzheimer’s disease pathology, obtaining two PET scans can be challenging in clinical practice. We sought to determine whether Aß-positivity in MCI patients can be predicted with only a single tau PET scan. Methods We prospectively recruited 105 MCI patients and performed two PET scans with 18 F-florbetaben and 18 F-flortaucipir with all patients. Regional 18 F-flortaucipir standardized uptake value ratios (SUVR) were measured using FreeSurfer-generated volumes-of-interest and with the cerebellar crus median as a reference. Results We classified 49 (46.7%) MCI patients as Aß-positive using visual assessment. In 12 regions showing greater tau uptake in the MCI-Aβ+ patients compared to the MCI-Aβ- patients, tau uptake in the entorhinal cortex showed the greatest area under the curve (AUC) value (AUC = 0.835, sensitivity/specificity = 73.5% /85.7%) for discriminating Aß-positivity. The second and third largest AUCs were obtained with tau uptake in the amygdala (AUC = 0.814, sensitivity/specificity = 65.3%/94.6%) and the parahippocampal cortex (AUC = 0.802, sensitivity/specificity = 67.4%/91.1%). However, post-hoc analyses revealed no statistical differences between the three regions. Conclusions Single tau PET scans may be helpful in the evaluation of disease state and stage at the same time in MCI patients.

scholarly journals Amyloid duration is associated with preclinical cognitive decline and tau PET

2019 ◽  
Author(s):  
Rebecca L. Koscik ◽  
Tobey J. Betthauser ◽  
Erin M. Jonaitis ◽  
Samantha L. Allison ◽  
Lindsay R. Clark ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Neurofibrillary Tangle ◽  
Amyloid Pet ◽  
Clinical Progression ◽  
Amyloid Positron Emission Tomography ◽  
Preclinical Ad ◽  
Positron Emission ◽  
Increased Risk ◽  
Tau Pet ◽  
Pet Scans

ABSTRACTINTRODUCTIONThis study applies a novel algorithm to longitudinal amyloid positron emission tomography (PET) imaging to identify age-heterogeneous amyloid trajectory groups, estimate the age and duration (chronicity) of amyloid positivity, and investigate chronicity in relation to cognitive decline and tau burden.METHODSCognitively unimpaired participants (n=257) underwent 1-4 amyloid PET scans. Group-based trajectory modeling was applied to participants with longitudinal scans (n=171) to identify and model amyloid trajectory groups, which were combined with Bayes’ theorem to estimate age and chronicity of amyloid positivity. Relationships between chronicity, cognition, clinical progression and tau PET (MK-6240) were investigated using regression models.RESULTSChronicity explained more heterogeneity in amyloid binding than age and binary amyloid status. Chronicity was associated with faster cognitive decline, increased risk of abnormal cognition, and higher entorhinal tau.DISCUSSIONAmyloid chronicity provides unique information about cognitive decline and neurofibrillary tangle development and may be useful to investigate preclinical AD.

FDG-PET Scans Find Secondary Infections

2005 ◽  
Vol 38 (19) ◽  
pp. 83
Author(s):  
PAM HARRISON
Keyword(s):  
Fdg Pet ◽  
Secondary Infections ◽  
Pet Scans

Lasers may make PET scans cheaper

Nature ◽  
2003 ◽  
Author(s):  
Philip Ball
Keyword(s):  
Pet Scans

Comparison of Fluorine(18)-fluorodeoxyglucose and Gallium(68)-citrate PET/CT in patients with tuberculosis

2019 ◽  
Vol 58 (05) ◽  
pp. 371-378
Author(s):  
Alfred O. Ankrah ◽  
Ismaheel O. Lawal ◽  
Tebatso M.G. Boshomane ◽  
Hans C. Klein ◽  
Thomas Ebenhan ◽  
...  
Keyword(s):  
Tracer Uptake ◽  
Pet Ct ◽  
The Mean ◽  
18F Fdg ◽  
Definition Of ◽  
Gallium 68 ◽  
Attending Physician ◽  
Pet Scans ◽  
The Brain

Abstract 18F-FDG and 68Ga-citrate PET/CT have both been shown to be useful in the management of tuberculosis (TB). We compared the abnormal PET findings of 18F-FDG- and 68Ga-citrate-PET/CT in patients with TB. Methods Patients with TB on anti-TB therapy were included. Patients had a set of PET scans consisting of both 18F-FDG and 68Ga-citrate. Abnormal lesions were identified, and the two sets of scans were compared. The scan findings were correlated to the clinical data as provided by the attending physician. Results 46 PET/CT scans were performed in 18 patients, 11 (61 %) were female, and the mean age was 35.7 ± 13.5 years. Five patients also had both studies for follow-up reasons during the use of anti-TB therapy. Thirteen patients were co-infected with HIV. 18F-FDG detected more lesions than 68Ga-citrate (261 vs. 166, p < 0.0001). 68Ga-citrate showed a better definition of intracerebral lesions due to the absence of tracer uptake in the brain. The mean SUVmax was higher for 18F-FDG compared to 68Ga-citrate (5.73 vs. 3.01, p < 0.0001). We found a significant correlation between the SUVmax of lesions that were determined by both tracers (r = 0.4968, p < 0.0001). Conclusion Preliminary data shows 18F-FDG-PET detects more abnormal lesions in TB compared to 68Ga-citrate. However, 68Ga-citrate has better lesion definition in the brain and is therefore especially useful when intracranial TB is suspected.

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