A case of mediastinal mixed germ cell tumor coexisting with benign testicular tumor

We report the case of a 17-year-old male with a testicular tumor and high serum levels of α-fetoprotein. The patient was treated with surgery followed by combination chemotherapy with bleomycin, etoposide, and cisplatin. Histologic examination showed features of a mixed germ cell tumor composed of mature teratoma, immature teratoma, embryonal carcinoma, yolk sac tumor, and polyembryoma. He is currently well, and his serum levels of α-fetoprotein have been normal more than 5 months after treatment. His brother, aged 17 years at the time, had a similar tumor removed from the right testicle 5 years previously.

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Rare presentation of a seminoma with mixed germ cell tumor in undescended inguinal testis

International Surgery Journal ◽

10.18203/2349-2902.isj20190415 ◽

2019 ◽

Vol 6 (2) ◽

pp. 611

Author(s):

Siddhartha Verma ◽

Heeralal Jakhar

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Germ Cell Tumors ◽

Testicular Tumor ◽

Cell Tumor ◽

Uneventful Recovery ◽

Predisposing Factor ◽

Rare Presentation ◽

Testicular Germ Cell ◽

Mixed Germ Cell Tumor

Cryptorchidism is the most common predisposing factor in the development of testicular germ cell tumors. Seminoma is the most common malignancy developing in a cryptorchid testis. A rare case of seminoma with mixed germ cell tumor in an undescended testis is reported here. A 35-year-old male patient presented with swelling in left inguinal region science 1.5year. This was smooth, firm to hard in consistency, restricted mobility and his left scrotum was empty. Serological markers α-FP, β-HCG, LDH were raised. Sonography and CT scan revealed a testicular tumor in undescended left inguinal testis. High inguinal orchidectomy was done. Patient had an uneventful recovery. The histopathology report of biopsy revealed a seminoma with mixed germ cell tumor. Early diagnosis and management of the undescended testicle are needed to preserve fertility and improve early detection of testicular malignancy. Therapy should begin between six months and two years of age and may consist of hormone or surgical treatment.

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Playing the long surveillance ball game: Metachronous testicular tumor developing after treatment and remission of extragonadal germ cell tumor

Rare Tumors ◽

10.1177/2036361319873196 ◽

2019 ◽

Vol 11 ◽

pp. 203636131987319

Author(s):

Alexander K Chow ◽

Jerome Hoeksema ◽

Dian Wang

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Testicular Tumor ◽

Percutaneous Biopsy ◽

Lactic Dehydrogenase ◽

Cell Tumor ◽

Mixed Germ Cell Tumor ◽

Platinum Based Chemotherapy ◽

Radical Orchiectomy ◽

Pure Seminoma

A 32-year-old man with vague abdominal pain was found to have enlarged para-aortic and mediastinal lymph nodes on computed tomography. He was diagnosed with retroperitoneal mixed germ cell tumor as confirmed on percutaneous biopsy. At the time of diagnosis, lactic dehydrogenase, human beta-chorionic gonadotropin, and alpha-fetoprotein were elevated. He completed four cycles of platinum-based chemotherapy with excellent response and no clinical disease progression. Three years later, he presented to the Urology clinic with a right testicular mass. His tumor markers remained negative. He was taken for a right radical orchiectomy with the pathology resulting in pure seminoma (pT1Nx).

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SEMINOMA ANAPLASTIK DENGAN YOLK SAC TUMOR TESTIS (MIXED GERM CELL TUMOR TESTIS)

JURNAL BIOMEDIK (JBM) ◽

10.35790/jbm.4.3.2012.1214 ◽

2013 ◽

Vol 4 (3) ◽

Author(s):

Lily Loho

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Testicular Tumor ◽

Yolk Sac ◽

Cell Tumor ◽

Yolk Sac Tumor ◽

Mixed Germ Cell Tumor ◽

Β Hcg

Abstract: Testicular cancer is relatively rare, accounting for less than 1% of malignant tumors affecting men. More than 90% of these tumors are of germ cell origin and most of them are found in young men between the ages of 15-34 years. Germ cell tumors are divided into seminoma and nonseminoma tumors. The seminoma makes up 30-40% of all testicular tumors. An anaplastic seminoma is a classic type of seminoma that has three or more mitosis under the high power microscopic field, combined with other morphologic criteria such as nuclear hyperchromasia, greater nucleolar sizes, pleomorphism, and an amount of necrosis. We reported a case of a 38-year-old male that was clinically diagnosed with a left testicular tumor and with an elevated alpha fetoprotein (AFP) and β human chorionic gonadotropin (β HCG) serum. The histopathological diagnosis was an anaplastic seminoma with a yolk sac tumor (YCT), i.e. a mixed germ cell tumor. Keywords: seminoma, testicular tumor, yolk sac tumor. Abstrak: Kanker testis relatif jarang, <1% dari semua kanker ganas pada laki-laki. Lebih dari 90 persen jenis tumor ini berasal dari sel germinal dan umumnya menyerang laki-laki muda berusia 15-34 tahun. Tumor sel germinal dibagi atas dua jenis: seminoma dan non seminoma. Jenis seminoma terdapat pada 30-40% dari seluruh tumor testis. Seminoma anaplastik adalah seminoma dengan ciri klasik mikroskopik berupa adanya tiga atau lebih sel-sel mitosis per lapangan pandang besar, disertai terdapatnya kriteria morfologik lain seperti inti sel hiperkromatik, anak inti berukuran besar, pleomorfik, dan terdapatnya sejumlah nekrosis. Kami melaporkan kasus seorang laki-laki berusia 38 tahun dengan diagnosis klinis tumor testis kiri disertai peningkatan kadar alfa feto protein (AFP) dan β human chorionic gonadotropin (β HCG) serum. Diagnosis histopatologik ialah seminoma anaplastik dengan tumor yolk sac (YCT), yaitu tumor sel germinal campuran. Kata kunci: seminoma, tumor testis, tumor yolk sac.

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Burned-out in a mixed germ cell tumor of the testis: The problem of pT0. Case report

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2014.4.389 ◽

2014 ◽

Vol 86 (4) ◽

pp. 389 ◽

Cited By ~ 1

Author(s):

Carlos Miacola ◽

Ottavio Colamonico ◽

Carlo Bettocchi ◽

Vito Ricapito ◽

Silvano Palazzo ◽

...

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Unusual Case ◽

Germ Cell Tumors ◽

Testicular Tumor ◽

Cell Tumor ◽

Testicular Tumors ◽

Mixed Germ Cell Tumor ◽

Scrotal Sonography ◽

Hypoechoic Nodule

Germ cell tumors constitute the majority of all testicular tumors, which are relatively rare overall and are mainly encountered in young adults and teenagers. The term ‘burned-out’ germ cell tumor refers to the presence of a metastatic germ cell tumor with histological regression of the primary testicular lesion. Clinical examination of the testes and scrotal sonography is the initial diagnosis of such neoplasms. We report an unusual case of a burned-out testicular tumor with metastases to retroperitoneal lymphnodes in an asymptomatic patient with right testicular hypoechoic nodule associated with multiple calcifications of the testicular parenchyma.

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OVARIAN GONADOBLASTOMA WITH MIXED GERM CELL TUMOR IN A 16-YEAR-OLD GIRL WITH 46, XX KARYOTYPE: A CASE REPORT

10.26226/morressier.5770e29cd462b80290b4bd28 ◽

2016 ◽

Author(s):

Zeliha Firat Cuylan

Keyword(s):

Case Report ◽

Germ Cell ◽

Germ Cell Tumor ◽

Cell Tumor ◽

Mixed Germ Cell Tumor

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442 Familial swyer syndrome associated with mixed germ cell tumor: a case report

10.1136/ijgc-2020-igcs.383 ◽

2020 ◽

Author(s):

M David ◽

C Castro

Keyword(s):

Case Report ◽

Germ Cell ◽

Germ Cell Tumor ◽

Cell Tumor ◽

Mixed Germ Cell Tumor ◽

Swyer Syndrome

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Mediastinal mixed germ cell tumor: A case report and literature review

Open Medicine ◽

10.1515/med-2021-0293 ◽

2021 ◽

Vol 16 (1) ◽

pp. 892-898

Author(s):

Xianwen Hu ◽

Dandan Li ◽

Jinhua Xia ◽

Pan Wang ◽

Jiong Cai

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Embryonal Carcinoma ◽

Yolk Sac ◽

Immature Teratoma ◽

Cell Tumor ◽

Yolk Sac Tumor ◽

Medical Attention ◽

Ct Guided ◽

Mixed Germ Cell Tumor

Abstract Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.

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