scholarly journals Burned-out in a mixed germ cell tumor of the testis: The problem of pT0. Case report

2014 ◽  
Vol 86 (4) ◽  
pp. 389 ◽  
Author(s):  
Carlos Miacola ◽  
Ottavio Colamonico ◽  
Carlo Bettocchi ◽  
Vito Ricapito ◽  
Silvano Palazzo ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Unusual Case ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Cell Tumor ◽  
Testicular Tumors ◽  
Mixed Germ Cell Tumor ◽  
Scrotal Sonography ◽  
Hypoechoic Nodule

Germ cell tumors constitute the majority of all testicular tumors, which are relatively rare overall and are mainly encountered in young adults and teenagers. The term ‘burned-out’ germ cell tumor refers to the presence of a metastatic germ cell tumor with histological regression of the primary testicular lesion. Clinical examination of the testes and scrotal sonography is the initial diagnosis of such neoplasms. We report an unusual case of a burned-out testicular tumor with metastases to retroperitoneal lymphnodes in an asymptomatic patient with right testicular hypoechoic nodule associated with multiple calcifications of the testicular parenchyma.

scholarly journals Rare presentation of a seminoma with mixed germ cell tumor in undescended inguinal testis

2019 ◽  
Vol 6 (2) ◽  
pp. 611
Author(s):  
Siddhartha Verma ◽  
Heeralal Jakhar
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Cell Tumor ◽  
Uneventful Recovery ◽  
Predisposing Factor ◽  
Rare Presentation ◽  
Testicular Germ Cell ◽  
Mixed Germ Cell Tumor

Cryptorchidism is the most common predisposing factor in the development of testicular germ cell tumors. Seminoma is the most common malignancy developing in a cryptorchid testis. A rare case of seminoma with mixed germ cell tumor in an undescended testis is reported here. A 35-year-old male patient presented with swelling in left inguinal region science 1.5year. This  was smooth, firm to hard in consistency, restricted mobility and his left scrotum was empty. Serological markers α-FP, β-HCG, LDH were raised.  Sonography and CT scan revealed a testicular tumor in undescended left inguinal testis. High inguinal orchidectomy was done. Patient had an uneventful recovery. The histopathology report of biopsy revealed a seminoma with mixed germ cell tumor. Early diagnosis and management of the undescended testicle are needed to preserve fertility and improve early detection of testicular malignancy. Therapy should begin between six months and two years of age and may consist of hormone or surgical treatment.

scholarly journals A rare case of mixed germ cell tumor in a teenage girl: a case report

2017 ◽  
Vol 6 (6) ◽  
pp. 2663
Author(s):  
Faraz S. Vali ◽  
Amit Kyal ◽  
Parul I. Chaudhary ◽  
Sujatha Das ◽  
Aprateem Mukherjee ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Germ Cell Tumors ◽  
Cell Tumor ◽  
Ca 125 ◽  
Gestational Choriocarcinoma ◽  
Mixed Germ Cell Tumor ◽  
Initial Surgery ◽  
Alpha Feto Protein

Germ cell tumors represent only 20% to 25% of all benign and malignant ovarian neoplasms. Mixed germ cell tumors are a rare variety of non–dysgerminomatous germ cell tumors. They contain two or more elements; the most frequent combination being a dysgerminoma and an EST (Endodermal Sinus Tumor). We present a case of malignant mixed germ cell tumor comprising of yolk sac tumor, embryonal carcinoma and choriocarcinoma. A 13-year-old girl presented with a huge 25 x 18 cm mass in abdomen with raised values of CA-125, hCG, AFP (alpha-feto protein) and LDH (lactate dehydrogenase). She underwent laparotomy followed by unilateral salpingoopherectomy and infracolic omentectomy. Histopathology report revealed malignant mixed germ cell tumor comprising predominantly of EST with elements of embryonal carcinoma and non-gestational choriocarcinoma. Following surgery, she was started on adjuvant chemotherapy (Bleomycin, Etoposide and Cisplatin regimen). Mixed germ cell tumor (YST/EST, non-gestational choriocarcinoma and embryonal carcinoma) is a very rare tumor. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients

scholarly journals Non Seminomatous Mixed Germ Cell Tumor of Testis with a Large Abdominal and Retroperitoneal Extension: A Case Report

2020 ◽  
Vol 22 (1-2) ◽  
pp. 88-92
Author(s):  
Rumita Kayastha ◽  
S Pradhan ◽  
R Acharya ◽  
M Aryal ◽  
A Shrestha ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Mixed Germ Cell Tumor ◽  
Contrast Enhanced ◽  
Cell Components ◽  
The Right ◽  
Enhanced Computed Tomography

Primary testicular germ cell tumors (PGCT) can be classified as seminomatous and non-seminomatous germ-cell tumor (NSGCT) types. Mixed germ cell tumors (MGCT), a subtype of NSGCT, contain more than one germ cell components. Here, we present a rare case of a MGCT composed of yolk sack tumor and teratoma which had a continuous large abdominal and retroperitoneal extension. A 43 years old male presented with complaints of discomfort and swelling over the right inguinoscrotal region. Ultrasonography (USG) showed a large ill-defined heteroechoic mass in the right inguinoscrotal region with vascularity and without separate visualization of right testis. Subsequent contrast enhanced Computed Tomography (CT) showed large enhancing mass in the right scrotal sac which was continuous with large abdominopelvic and retroperitoneal mass through the right inguinal canal. Tru-Cut biopsy of the scrotal mass showed MGCT with yolk sac and teratoma component. Patient underwent 6 cycles of chemotherapy followed by Right Radical Inguinal Orchidectomy.

Cystic Trophoblastic Tumor in a Primary Central Nervous System Post-Chemotherapy Germ Cell Tumor: The First Case Report

2020 ◽  
Vol 28 (8) ◽  
pp. 925-928
Author(s):  
Ramya Gadde ◽  
Kanika Arora ◽  
Michelle Madden Felicella ◽  
Sohrab Arora ◽  
Liang Cheng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Cell Tumor ◽  
Smooth Muscle Tissue ◽  
Trophoblastic Tumor ◽  
First Case

Cystic trophoblastic tumor (CTT) is an uncommon trophoblastic proliferation of germ cell tumor origin, mostly reported in post-chemotherapy metastases of testicular germ cell tumors and rarely primary untreated testicular tumors. To date, we are not aware of occurrence in a non-testicular tumor. A 12-year-old boy presented with limb swelling, increased appetite, weight gain, and precocious puberty. Evaluation revealed right frontal lobe mass and elevated α-fetoprotein and β-human chorionic gonadotrophin. After response to neoadjuvant chemotherapy, the tumor was resected. Microscopically, the resection contained predominantly smooth muscle tissue with scattered small foci of glandular teratoma and CTT. Immunohistochemistry (SALL4, glypican 3) revealed no residual yolk sac tumor. Fluorescence in situ hybridization revealed gain of chromosome 12p. The patient has been disease-free for 13 years. This report expands the spectrum of primary central nervous system germ cell tumors with the occurrence of CTT in this site.

Testicular Mixed Germ Cell Tumor with Polyembryoma Component in Brothers

2005 ◽  
Vol 8 (1) ◽  
pp. 92-97 ◽  
Author(s):  
Sevgi Bakaris ◽  
Sefa Resim ◽  
Nurdan Tunali
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Mature Teratoma ◽  
Testicular Tumor ◽  
Serum Levels ◽  
High Serum ◽  
Cell Tumor ◽  
Mixed Germ Cell Tumor ◽  
The Right

We report the case of a 17-year-old male with a testicular tumor and high serum levels of α-fetoprotein. The patient was treated with surgery followed by combination chemotherapy with bleomycin, etoposide, and cisplatin. Histologic examination showed features of a mixed germ cell tumor composed of mature teratoma, immature teratoma, embryonal carcinoma, yolk sac tumor, and polyembryoma. He is currently well, and his serum levels of α-fetoprotein have been normal more than 5 months after treatment. His brother, aged 17 years at the time, had a similar tumor removed from the right testicle 5 years previously.

Bilateral Testicular Tumors: Seminoma and Mixed Germ Cell Tumor

Radiographics ◽  
2005 ◽  
Vol 25 (3) ◽  
pp. 835-839 ◽  
Author(s):  
Walid K. Adham ◽  
Bharat K. Raval ◽  
Maria C. Uzquiano ◽  
Luciano B. Lemos
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Tumors ◽  
Mixed Germ Cell Tumor

scholarly journals Playing the long surveillance ball game: Metachronous testicular tumor developing after treatment and remission of extragonadal germ cell tumor

Rare Tumors ◽  
2019 ◽  
Vol 11 ◽  
pp. 203636131987319
Author(s):  
Alexander K Chow ◽  
Jerome Hoeksema ◽  
Dian Wang
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Tumor ◽  
Percutaneous Biopsy ◽  
Lactic Dehydrogenase ◽  
Cell Tumor ◽  
Mixed Germ Cell Tumor ◽  
Platinum Based Chemotherapy ◽  
Radical Orchiectomy ◽  
Pure Seminoma

A 32-year-old man with vague abdominal pain was found to have enlarged para-aortic and mediastinal lymph nodes on computed tomography. He was diagnosed with retroperitoneal mixed germ cell tumor as confirmed on percutaneous biopsy. At the time of diagnosis, lactic dehydrogenase, human beta-chorionic gonadotropin, and alpha-fetoprotein were elevated. He completed four cycles of platinum-based chemotherapy with excellent response and no clinical disease progression. Three years later, he presented to the Urology clinic with a right testicular mass. His tumor markers remained negative. He was taken for a right radical orchiectomy with the pathology resulting in pure seminoma (pT1Nx).

scholarly journals SEMINOMA ANAPLASTIK DENGAN YOLK SAC TUMOR TESTIS (MIXED GERM CELL TUMOR TESTIS)

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Lily Loho
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Testicular Tumor ◽  
Yolk Sac ◽  
Cell Tumor ◽  
Yolk Sac Tumor ◽  
Mixed Germ Cell Tumor ◽  
Β Hcg

Abstract: Testicular cancer is relatively rare, accounting for less than 1% of malignant tumors affecting men. More than 90% of these tumors are of germ cell origin and most of them are found in young men between the ages of 15-34 years. Germ cell tumors are divided into seminoma and nonseminoma tumors. The seminoma makes up 30-40% of all testicular tumors. An anaplastic seminoma is a classic type of seminoma that has three or more mitosis under the high power microscopic field, combined with other morphologic criteria such as nuclear hyperchromasia, greater nucleolar sizes, pleomorphism, and an amount of necrosis. We reported a case of a 38-year-old male that was clinically diagnosed with a left testicular tumor and with an elevated alpha fetoprotein (AFP) and β human chorionic gonadotropin (β HCG) serum. The histopathological diagnosis was an anaplastic seminoma with a yolk sac tumor (YCT), i.e. a mixed germ cell tumor. Keywords: seminoma, testicular tumor, yolk sac tumor.   Abstrak: Kanker testis relatif jarang,  <1% dari semua kanker ganas pada laki-laki. Lebih dari 90 persen jenis tumor ini berasal dari sel germinal dan umumnya menyerang laki-laki muda berusia 15-34 tahun. Tumor sel germinal dibagi atas dua jenis: seminoma dan non seminoma. Jenis seminoma terdapat pada 30-40% dari seluruh tumor testis. Seminoma anaplastik adalah seminoma dengan ciri klasik mikroskopik berupa adanya tiga atau lebih sel-sel mitosis per lapangan pandang besar, disertai terdapatnya kriteria morfologik lain seperti inti sel hiperkromatik, anak inti berukuran besar, pleomorfik, dan terdapatnya sejumlah nekrosis. Kami melaporkan kasus seorang laki-laki berusia 38 tahun dengan diagnosis klinis tumor testis kiri disertai peningkatan kadar alfa feto protein (AFP) dan β human chorionic gonadotropin (β HCG) serum. Diagnosis histopatologik ialah  seminoma anaplastik dengan tumor yolk sac (YCT), yaitu tumor sel germinal campuran. Kata kunci: seminoma, tumor testis, tumor yolk sac.

scholarly journals Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Houda Alatassi ◽  
Brittany E. O’Bryan ◽  
Jamie C. Messer ◽  
Zhenglong Wang
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Lung Metastases ◽  
English Literature ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Mixed Germ Cell Tumor

Adult extrarenal nephroblastoma is a very rare tumor. Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare. To our knowledge, only three cases have been reported in the English literature. We report a case of a 19-year-old man who presented with a large right testicle. Image studies showed a large retroperitoneal mass along with liver and lung metastases. Orchiectomy demonstrated a mixed germ cell tumor composed of yolk sac tumor, embryonal carcinoma, and mature and immature teratoma with a significant portion of nephroblastoma. The patient received chemotherapy and no recurrence was noted during six months of followup. WT-1 expression was also studied due to the lack of consistency of its expression in testicular nephroblastoma in the literature. We also present a discussion and review of the literature due to its rarity, which indicate an adverse prognosis for patients with nephroblastoma components receiving standard chemotherapeutical regimes for testicular germ cell tumors.

scholarly journals Mixed germ cell tumor composed of a tridermic testicular teratoma and seminoma in a rooster

2019 ◽  
Vol 31 (3) ◽  
pp. 395-398 ◽  
Author(s):  
Vincent J. Tavella ◽  
Jessica N. Walters ◽  
Lisa M. Crofton ◽  
Tanya LeRoith
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Primordial Germ Cell ◽  
Germ Cell Tumors ◽  
Large Mass ◽  
Cell Tumor ◽  
Seminiferous Tubules ◽  
Diagnostic Laboratory ◽  
Mixed Germ Cell Tumor ◽  
History Of

A 5-y-old backyard Araucana–Americana rooster was presented to the regional diagnostic laboratory with a history of progressive lethargy and respiratory signs. Autopsy revealed a single large mass of testicular origin in the coelomic cavity, causing compression of other organs. Histologically, the mass was 1 neoplasm with mixed components of 2 different germ cell tumors, namely a teratoma composed of elements of all 3 primordial germ cell lines (ectoderm, mesoderm, and endoderm), and a seminoma consisting of round or polygonal cells arranged in sheets supported by a scant fibrovascular stroma. Teratomas and seminomas are both considered to be uncommon neoplasms in poultry medicine. A testicular teratoma is composed of mature embryonic tissue derived from at least 2 of the 3 germinal layers. Seminomas and teratomas both arise from the germinal epithelium of seminiferous tubules and are classified as germ cell tumors. This neoplastic mass thus is a rare case of a mixed germ cell tumor.

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