AGROCHEMICAL INDICES OF CHERNOZEM LEACHED ON APPLICATION OF BIOMODIFIED FERTILIZER OF PROLONGED ACTION IN FRUIT ORCHARD

ABSTRACT 17α-hydroxyprogesterone-4-14C-17α-caproate (HPC), a long-acting progestational agent, was incubated with homogenates of rat liver and human placenta. The rat liver was found to reduce Ring A of HPC under anaerobic conditions to form allopregnane-3β,17α-diol-20-one-17α-caproate and pregnane-3β,17α-diol-20-one-17α-caproate, the allopregnane isomer being the major product. The caproic acid ester was neither removed nor altered during the incubation. Placental tissue did not attack HPC under conditions where the 20-ketone of progesterone was reduced. It is postulated that this absence of attack on the side chain is due to steric hindrance from the caproate ester, and that this may account for the prolonged action of HPC.

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Increased susceptibility to hypoxia of prolonged action potential duration in ventricular papillary muscles from diabetic rats

Diabetes ◽

10.2337/diabetes.39.12.1485 ◽

1990 ◽

Vol 39 (12) ◽

pp. 1485-1489 ◽

Cited By ~ 3

Author(s):

M. Aomine ◽

S. Nobe ◽

M. Arita

Keyword(s):

Action Potential ◽

Action Potential Duration ◽

Diabetic Rats ◽

Papillary Muscles ◽

Prolonged Action ◽

Prolonged Action Potential Duration ◽

Increased Susceptibility

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Evaluation of the effectiveness of the drug prolonged action Lipomaс 2% for helminthosis of small cattle

Veterinary Medicine Journal ◽

10.30896/0042-4846.2020.23.5.35-37 ◽

2020 ◽

Vol 23 (05) ◽

pp. 35-37

Author(s):

K.F. Fatakhov ◽

◽

D.A. Devrishov ◽

O.B. Litvinov ◽

A.D. Devrishov ◽

...

Keyword(s):

Prolonged Action

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BIOPOLYMER PRESOWING TREATMENT OF SEEDS ENSURING THE PROLONGED ACTION

Izvestia Ufimskogo Nauchnogo Tsentra RAN ◽

10.31040/2222-8349-2018-0-4-90-94 ◽

2018 ◽

Vol 0 (4) ◽

pp. 90-94

Author(s):

S.P. Chetverikov ◽

◽

R.K. Bikkuzina ◽

D.V. Chetverikova ◽

◽

...

Keyword(s):

Prolonged Action ◽

Presowing Treatment

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Fluorinated tricyclic neuroleptics with prolonged action: 8-Methoxy, 8-ethoxy, 8-ethylthio and 8-hydroxy derivatives of 3-fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19821382 ◽

1982 ◽

Vol 47 (5) ◽

pp. 1382-1391 ◽

Cited By ~ 2

Author(s):

Jiří Jílek ◽

Josef Pomykáček ◽

Jiřina Metyšová ◽

Miroslav Protiva

Keyword(s):

Acetic Acid ◽

Polyphosphoric Acid ◽

Prolonged Action ◽

Substitution Reactions ◽

Methoxy Derivative ◽

Chloro Derivatives ◽

Boron Tribromide ◽

Derivatives Of ◽

Central Depressant ◽

Boiling Toluene

Acids IIa-c were prepared by reactions of (4-fluoro-2-iodophenyl)acetic acid with 4-methoxythiophenol, 4-ethoxythiophenol and 4-(ethylthio)thiophenol and cyclized with polyphosphoric acid in boiling toluene to dibenzo[b,f]thiepin-10(11H)-ones IIIa-c. Reduction with sodium borohydride afforded the alcohols IVa-c which were treated with hydrogen chloride and gave the chloro derivatives Va-c. Substitution reactions with 1-methylpiperazine resulted in the title compounds Ia-c out of which the methoxy derivative Ia was transformed by demethylation with boron tribromide to the phenol Id. Compounds Ia-d are very potent neuroleptics exhibiting a clear prolongation of the central depressant and some prolongation of the cataleptic activity.

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Quantitative relations between structure and antiinflammatory activity of aryloxoalkanoic acids

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19881862 ◽

1988 ◽

Vol 53 (8) ◽

pp. 1862-1872 ◽

Cited By ~ 11

Author(s):

Miroslav Kuchař ◽

Eva Maturová ◽

Bohumila Brunová ◽

Jaroslava Grimová ◽

Hana Tomková ◽

...

Keyword(s):

Regression Analysis ◽

Structural Changes ◽

Antiinflammatory Activity ◽

Structural Parameters ◽

Considerable Effect ◽

Antiinflammatory Effect ◽

Prolonged Action ◽

Preclinical Development ◽

Indicator Variables ◽

Inhibitory Activities

The antiinflammatory effect of a series of aryloxoalkanoic acids II and of their biphenyl derivatives III was examined by measuring the inhibition of the development of carageenan- and adjuvant-induced edemas. The quantitative relations between the antiinflammatory effect and physicochemical and structural parameters of the compounds tested were evaluated. The equations obtained by the method of regression analysis showed a significant linear dependence of both inhibitory activities on the lipophilicity of the compounds and a considerable effect of some structural changes as expressed by indicator variables. The antiinflammatory effect is especially enhanced in both tests by the presence of a cyclic substituent at the aromatic ring. The high antiinflammatory effect of biphenylyl derivatives III is paralleled by their prolonged action. The prolongation of the effect is most likely a result of a suitable biotransformation of acid III to an efficient metabolite. The structural requirements which resulted from both the regression analysis and from the hypothesis of biotransformation of acids III were utilized in the synthesis of suitably substituted biphenylyloxoalkanoic acids. By this approach derivatives IIIe-i were obtained some of which showed a high antiinflammatory and also protracted effect. 4-(2',4'-Difluorbiphenylyl)-4-oxo-2-methylbutanoic acid (VÚFB-16 066, Flobufen) was chosen for further preclinical development.

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