scholarly journals Age Features of Testosterone Deficiency in Men with Metabolic Syndrome and Diabetes Mellitus Type 2 (Literature Review with Own Data)

2018 ◽  
Vol 0 (6) ◽  
pp. 79-82
Author(s):  
В. Є. Лучицький ◽  
Є. В. Лучицький
2020 ◽  
Vol 26 (4) ◽  
pp. 2776-2791
Author(s):  
Claudio Urrea ◽  
Alexis Mignogna

This study involved the development of an expert system for the pre-diagnosis of hypertension, diabetes mellitus type 2 and metabolic syndrome. The expert system has been developed using web technologies, PHP, Apache and MySQL with CLIPS tool; the expert system includes three algorithms designed by the authors, one for each disease. The objective of this study is to provide an expert system capable of performing a pre-diagnosis for early detection of hypertension, diabetes mellitus type 2 and metabolic syndrome. The methodology to build the system consists in associated risk factors, clinical variables diagnosis criteria based on World Health Organization standards in three algorithms and then develop a program that interacts with users, besides the expert system is compared with the existing expert systems in order to show its originality and innovation. The rules of systems are designed using CLIPS systems and the Architecture Apache, MySQL and PHP for the user interface and database. The system was validated by 72 patient(s) and 3 real doctors, the total result over 72 patient(s) is low risk 16.6 percent, moderate risk 30.5 percent, moderate high risk 13.8 percent, high risk 23.6 percent, very high risk 15.2 percent, and the doctors’ feedback was similar to that shown by the system. The number of rules to create the algorithms and the criteria used were adequate and sufficient to obtain the pre-diagnosis of each disease; in addition, the languages used to design and create the web application were stable. All users who used the system obtained similar results to those obtained by doctors.


2018 ◽  
Vol 25 (3) ◽  
pp. 218
Author(s):  
Vitalina Petrenko ◽  
Anatoliy Kubyshkin ◽  
Irina Fomochkina ◽  
Natalia Kornienko ◽  
Alexander Kucherenko

2014 ◽  
Vol 5 ◽  
pp. S116
Author(s):  
M. Pozdnyakova ◽  
K.I. Prashchayeu ◽  
N. Ilnitski ◽  
V. Pavlova ◽  
V. Bashuk ◽  
...  

2021 ◽  
Vol 58 ◽  
pp. eUJ3944-eUJ3944
Author(s):  
Larissa Emilly Fiusa do Monte ◽  
◽  
Juliana Ramos Carneiro ◽  
Antonio Camilo Correia Mendes Filho ◽  
Leonardo Silva dos Santos ◽  
...  

O câncer de pâncreas possui alta taxa de mortalidade e, com frequência, seu diagnóstico tem sido associado ao de diabetes mellitus tipo 2 (DMT2), embora os mecanismos fisiopatológicos dessa relação ainda necessitem de esclarecimentos. Dessa forma, o objetivo deste estudo é analisar os aspectos da associação entre a DMT2 e sua terapia farmacológica com o desenvolvimento de carcinoma pancreático. Para este fim, realizou-se uma busca criteriosa da literatura publicada entre 2015 e 2020 em bases de dados eletrônicas em saúde, e, após o processo de seleção, 13 artigos na BVS e 14 na PUBMED foram incluídos neste estudo. Em suma, a característica inflamatória da DMT2, a hiperinsulinemia e a resistência à insulina são hipóteses fisiopatológicas da associação. Outrossim, é significativa a relação da diabetes de longa duração com o desenvolvimento do carcinoma, apesar de a diabetes de início recente também demonstrar-se relevante. Ademais, a associação entre medicamentos antidiabéticos e câncer de pâncreas também é avaliada. Sob esse viés, alguns medicamentos, como a metformina, estão associados a efeitos antitumorais. Em contrapartida, as incretinas estão relacionadas à carcinogênese, devido aos seus potenciais efeitos deletérios no pâncreas. Em paralelo, a insulina pode amplificar a relação entre hiperinsulinemia e o risco de malignidade, assim como drogas como as sulfonilureias, que estão associadas ao risco aumentado de câncer por provocar estimulação anormal da proliferação celular.


2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
K. Keramida ◽  
E. Karpanou ◽  
G. Vyssoulis ◽  
C. D. Olympios ◽  
C. Stefanadis ◽  
...  

Background: Arterial hypertension (AH), metabolic syndrome (MS) and diabetes mellitus type 2 (DM2) are interrelated metabolic disorders. The aim of our study was to evaluate how the coexistence of MS or DM2 with AH influences arterial reactivity during cold pressor test (CPT). Methods: We studied 102 patients, 32 with AH (Group A), 38 with AH and MS (Group B) and 32 with AH and DM2 (Group C). All patients underwent full laboratory evaluation and measurement of systolic and diastolic blood pressure (SBP and DBP), heart rate (HR) and carotid-femoral pulse wave velocity (PWVc-f) before and during CPT. Results: During CPT PWVc-f, SBP, DBP and HR were increased significantly in all studied groups, but the change of PWVc-f and HR during CPT was significantly greater in group A compared to group C. On the contrary, the coexistence of MS or DM2 with AH does not alter the response of BP to CPT. Conclusion: The increase of CV risk resulting from the coexistence of MS or DM2 with AH, is best expressed by PWVc-f, while the change of the former and HR during CPT possibly reflects dysfunction of the autonomic nervous system.


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