scholarly journals Neuroprotective effect of Gracilaria corticata against aluminium-induced neurotoxicity in the hippocampus and cerebral cortex of rat brain: Biochemical and histological approach

2019 ◽  
Vol 5 (3) ◽  
pp. 604-613
Author(s):  
Asha Chacko ◽  
Sibi P. Ittiyavirah
Keyword(s):  
Cerebral Cortex ◽  
Rat Brain ◽  
Neuroprotective Effect ◽  
Gracilaria Corticata

Long-lasting neuroprotective effect of sildenafil against 3,4-methylenedioxymethamphetamine- induced 5-hydroxytryptamine deficits in the rat brain

2011 ◽  
Vol 90 (2) ◽  
pp. 518-528 ◽  
Author(s):  
Elena Puerta ◽  
Lucia Barros-Miñones ◽  
Isabel Hervias ◽  
Violeta Gomez-Rodriguez ◽  
Lourdes Orejana ◽  
...  
Keyword(s):  
Rat Brain ◽  
Neuroprotective Effect

Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain

2001 ◽  
Vol 905 (1-2) ◽  
pp. 91-103 ◽  
Author(s):  
Diana Cash ◽  
John S Beech ◽  
Richard C Rayne ◽  
Philip M.W Bath ◽  
Brian S Meldrum ◽  
...  
Keyword(s):  
Rat Brain ◽  
Neuroprotective Effect ◽  
Focal Ischaemia

scholarly journals The role of Ca2+ in the protoveratrine-induced release of γ-aminobutyrate from rat brain slices

1980 ◽  
Vol 190 (2) ◽  
pp. 333-339 ◽  
Author(s):  
M C W Minchin
Keyword(s):  
Cerebral Cortex ◽  
Rat Brain ◽  
Dose Response ◽  
Transmitter Release ◽  
Response Curve ◽  
Brain Slices ◽  
Veratrum Alkaloids ◽  
Similar Dose ◽  
22Na Uptake

1. Protoveratrine A increased the release of gamma-amino[3H]butyrate from small slices of rat cerebral cortex. This effect increased with increasing protoveratrine concentration, reaching a maximum at 100 microM. 2. Removal of Ca2+ from the superfusing medium did not change the increase in release due to 10 microM-protoveratrine; however, the Ca2+ antagonists, compound D-600, La3+, Mn2+, Mg2+ and also high Ca2+ concentration inhibited the effect of the alkaloid, as did procaine. 3. Protoveratrine A increased the uptake of 22Na+ into the slices with a similar dose-response curve to that found for gamma-aminobutyrate release. For the most part, the substances that inhibited protoveratrine-stimulated gamma-aminobutyrate release also inhibited 22Na+ uptake, although the correlation was not perfect. 4. Although extracellular Ca2+ is not required for protoveratrine-induced gamma-aminobutyrate release, an increase in Na+ influx that is susceptible to inhibition by some Ca2+ antagonists does appear to be associated with this phenomenon. However, the possibility remains that changes in the free intracellular Ca2+ concentration may be important for transmitter release induced by depolarizing veratrum alkaloids.

scholarly journals Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ke-Ying Zhang ◽  
Gang Rui ◽  
Jun-Ping Zhang ◽  
Ling Guo ◽  
Guang-Zhou An ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Rat Brain ◽  
Neuroprotective Effect ◽  
Cathodal Tdcs

scholarly journals In Vitro Antioxidant Activity of Purple Grape Juice (Vitis Labrusca) against Temozolamide Treatment in Rat Brains

Beverages ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 99
Author(s):  
Tatiane Gabardo ◽  
Marina Rocha Frusciante ◽  
Jessica Pereira Marinho ◽  
Manuela dos Santos ◽  
Ana Abujamra ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Protein Oxidation ◽  
Neuroprotective Effect ◽  
Grape Juice ◽  
Thiobarbituric Acid ◽  
Redox Balance ◽  
Sod Activity ◽  
The Central Nervous System ◽  
In Vitro Antioxidant Activity

Considering that grape juice has high levels of phenolic compounds that produce beneficial physiological effects, important for the maintenance of redox balance, the aim of this study was to evaluate the in vitro neuroprotective effect of purple grape juice on the oxidative damage caused by temozolomide (TMZ) in the cerebral cortex, hippocampus, and cerebellum of Wistar rats. In pre-incubation, TMZ increased thiobarbituric acid reactive substances (TBARS) in the cerebral cortex and cerebellum, enhanced protein oxidation in all tissues studied, increased superoxide dismutase (SOD) activity in the hippocampus, decreased SOD activity in the cerebellum, and enhanced catalase (CAT) activity in the cerebral cortex and cerebellum. In co-incubation, there was enhanced protein oxidation in the cerebral cortex and cerebellum, decreased SOD activity in the cerebellum, inhibition of CAT activity in the hippocampus, and increased CAT activity in the cerebellum. Purple grape juice improved these oxidative alterations. Therefore, the intake of grape juice might have a protective effect against diseases that affect the oxidative status of the central nervous system.

Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injury

Glia ◽  
2010 ◽  
Vol 58 (15) ◽  
pp. 1881-1892 ◽  
Author(s):  
So-Young Hwang ◽  
Joo-Hyun Shin ◽  
Ji-Sun Hwang ◽  
Song-Yi Kim ◽  
Jin-A Shin ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Brain ◽  
Brain Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Neuroprotective Effect ◽  
Ischemia Reperfusion
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