Improvement in a Patient with Active Systemic Lupus Erythematosous Treated with Transplant of Intestinal Microbiota

Abstract BackgroundSystemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by being multi-systemic and, therefore, reaching various organs and affecting mainly young women. Its pathogenesis comprehends many factors, including the interaction between microbiota and immune system. The aim of this systematic review protocol is to assess the relationship between intestinal microbiota and SLE in activity, highlighting microbiota representative patterns regarding quantity and diversity. MethodsThe systematic review will be carried out using the following databases: Medline via PubMed, Scopus, and EMBASE. Inclusion criteria will be: observational studies (cross-sectional, cohort, and case-control) that analyzed intestinal microbiota composition in patients with SLE, with no restriction of age or sex, which fulfilled the classification criteria of either Systemic Lupus International Collaborating Clinic (SLICC), European League Against Rheumatism (EULAR) or American College of Rheumatology (ACR) and used the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) to classify disease in activity or remission. The Downs & Black Scale will be applied to analyze the risk of bias during study selection and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) will be used to assess the quality of the evidence of the selected studies.DiscussionThis review will identify investigation gaps, for better understanding of aspects related to etiopathogenesis and to the inflammatory process during SLE progression. Systematic review registration PROSPERO registration: CRD42021229322

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AB0947 The Role of Musculoskeletal Ultrasound in Managing Systemic Lupus Erythematosous and Sjogren's Syndrome in A Real Life Clinic: Table 1.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.2887 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 1225.2-1225

Author(s):

E. Ntatsaki ◽

B. Gracia-Tello ◽

C. Ciurtin

Keyword(s):

Sjögren’S Syndrome ◽

Sjögren's Syndrome ◽

Real Life ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Musculoskeletal Ultrasound ◽

Systemic Lupus ◽

Systemic Lupus Erythematosous ◽

Sjögren‘S Syndrome

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ANTI-TOPOISOMERASE 1 ANTIBODIES ARE RARE IN SYSTEMIC LUPUS ERYTHEMATOSOUS (SLE) AND ARE FOUND ONLY IN ANTI-DS DNA POSITIVE PATIENTS

10.26226/morressier.56e174d5d462b8028d88a9a4 ◽

2016 ◽

Author(s):

Micaela Fredi

Keyword(s):

Systemic Lupus ◽

Topoisomerase 1 ◽

Systemic Lupus Erythematosous

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FRI0119 Hla-dm polymorphism in systemic lupus erythematosous (sle)

10.1136/annrheumdis-2001.154 ◽

2001 ◽

Author(s):

C Da Silva Simoes ◽

J Morel ◽

MT Salles ◽

O Avinens ◽

J Sany ◽

...

Keyword(s):

Systemic Lupus ◽

Systemic Lupus Erythematosous

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Intestinal microbiota and active systemic lupus erythematosus: a systematic review

Advances in Rheumatology ◽

10.1186/s42358-021-00201-8 ◽

2021 ◽

Vol 61 (1) ◽

Author(s):

Juliana Rosa Pires Vieira ◽

Andréa Toledo de Oliveira Rezende ◽

Marcos Rassi Fernandes ◽

Nilzio Antonio da Silva

Keyword(s):

Systematic Review ◽

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Intestinal Microbiota ◽

Lupus Erythematosus ◽

Activity Index ◽

Disease Activity Index ◽

Systemic Lupus ◽

American College Of Rheumatology ◽

European League Against Rheumatism

Abstract Background Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by being multi-systemic and, therefore, reaching various organs and affecting mainly young women. Its pathogenesis comprehends many factors, including the interaction between microbiota and immune system. This systematic review assessed the relationship between intestinal microbiota and SLE in activity, highlighting microbiota representative patterns regarding quantity and diversity. Methods This study considered researches carried out in patients with SLE, with no restriction of age or gender, which fulfilled the classification criteria of either Systemic Lupus International Collaborating Clinic (SLICC), American College of Rheumatology (ACR) or European League Against Rheumatism (EULAR) and used the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) to classify disease in activity or remission were included. The search was carried out from October, 2020 to January, 2021 using the following databases: Medline via Pubmed, Scopus, and Embase. Five papers were included with a total of 288 participants with SLE. Results Regarding microbiota in patients with SLE in activity, there was significant increase in the following genera: Lactobacillus, Streptococcus, Megasphaera, Fusobacterium, Veillonella, Oribacterium, Odoribacter, Blautia, and Campylobacter. On the other hand, decrease in Faecalibacterium and Roseburia genera as well as Ruminococcus gnavus species was observed in remission cases, showing differences between the microbiota profile in SLE in activity and in remission. Conclusions Results suggest that dysbiosis may be involved in the disease activity process. Trial registration CRD42021229322.

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DRY SYMPTOMS, HISTOLOGICAL ABNORMALITIES IN LABIAL SALIVARY GLANDS AND SJOGREN’S SYNDROME ARE COMMON IN SYSTEMIC LUPUS ERYTHEMATOSOUS.

10.5151/sbr2019-407 ◽

2019 ◽

Author(s):

ANA PAULA ESPINDULA GIANORDOLI ◽

RAFAELLA VILA REAL BARBOSA ◽

MARIA CARMEN LOPES FERREIRA SILVA SANTOS ◽

FABIANO CADE ◽

ERICA VIEIRA SERRANO ◽

...

Keyword(s):

Salivary Glands ◽

Sjögren’S Syndrome ◽

Sjögren's Syndrome ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Systemic Lupus ◽

Systemic Lupus Erythematosous ◽

Sjögren‘S Syndrome

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Organized Intraglomerular Deposits in NZB Mouse Disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066772 ◽

1971 ◽

Vol 29 ◽

pp. 544-545

Author(s):

Francis R. Comerford ◽

Alan S. Cohen

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Antinuclear Antibodies ◽

Human Systemic Lupus Erythematosus ◽

Systemic Lupus ◽

Glomerular Lesion ◽

Ultrastructural Studies ◽

Dense Deposits ◽

Experimental Nephritis ◽

Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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