Multi-modality therapies for advanced small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): three case reports and literature review

Definitive cytomorphologic diagnosis of small cell carcinoma of the uterine cervix is possible but can be challenging in routine cervicovaginal cancer screening specimens. Several small series of reported cases of cervical small cell carcinoma have shown this uncommon malignancy to represent fewer than 2% of all invasive cervical cancers. This tumor type is associated with poor prognosis and rapid disease progression and can develop to an advanced stage in the interval between screening visits. Only rare case reports of small cell carcinoma arising in gravid cervices are known. In the current case a 29-year-old, gravida 6, para 2, pregnant (10-week gestation) female presented with postcoital bleeding. A definitive diagnosis of small cell carcinoma of the cervix was made possible by liquid based Pap testing with ancillary cell block preparation allowing for immunocytochemical characterization of the lesional cell population.

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Small cell carcinoma of the ovary: A rapidly lethal tumor occurring in the young

Gynecologic Oncology ◽

10.1016/0090-8258(85)90031-9 ◽

1985 ◽

Vol 22 (2) ◽

pp. 233-239 ◽

Cited By ~ 25

Author(s):

Bruce Patsner ◽

M.Steven Piver ◽

Shashikant B. Lele ◽

Yoshiaka Tsukada ◽

Kenneth Bielat ◽

...

Keyword(s):

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Small Cell ◽

Carcinoma Of The Ovary

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Distal Humerus as Delayed Site of Metastasis from Small Cell Carcinoma of Gallbladder

Case Reports in Gastrointestinal Medicine ◽

10.1155/2013/946835 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Mutahir A. Tunio ◽

Mushabbab AlAsiri ◽

Asma Mohammed F. Ali ◽

Eyad Fawzi AlSaeed ◽

Muhammad Shuja ◽

...

Keyword(s):

Cell Carcinoma ◽

Small Cell Carcinoma ◽

World Literature ◽

Case Reports ◽

Locally Advanced ◽

Distal Humerus ◽

Small Cell ◽

Rare Entity ◽

Dismal Prognosis ◽

Advanced Stages

Background. Small cell carcinoma (SCC) of the gallbladder is a rare entity and is often seen in elderly women. SCC of gallbladder is typically a nonsecretory carcinoid tumor without overt clinical symptoms and is often discovered at advanced stages. SCC of gallbladder carries a dismal prognosis as compared to SCC of lung and adenocarcinoma of gallbladder. To date, only 73 case reports have been published in the world literature.Case Presentation. Herein, we report a case of a 73-year-old Saudi woman who presented with one week history of right upper quadrant abdominal pain and obstructive jaundice and was found to be a case of locally advanced, metastatic SCC of gallbladder cT4N1M1 (liver, para-aortic lymph nodes, and bone). The patient was treated with neoadjuvant etoposide and cisplatin (EP) chemotherapy three cycles after biliary stenting followed by radical cholecystectomy, lymphadenectomy, and adjuvant EP chemotherapy and then one year later developed distal humerus osseous metastasis.Conclusion. SCC of the gallbladder is very rare entity and is often seen at advanced stages. Osseous metastases of peripheral skeleton from SCC gallbladder are rarely reported. Surgery is curative option but only for early stage tumors. Incorporation of chemotherapy along with radical resection increases the survival.

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