Alpha-Fetoprotein (AFP) Levels in Maternal Serum and Amniotic Fluid in Singleton Pregnant Women in Their 10th-25th Week Post Last Menstrual Period

1977 ◽  
Vol 56 (s69) ◽  
pp. 20-24 ◽  
Author(s):  
S. G. O. Johansson ◽  
B. Kjessler ◽  
M. S. Sherman ◽  
J. Wahlström
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Menstrual Period ◽  
Last Menstrual Period

scholarly journals Evaluating the Agreement of Risk Categorization for Fetal Down Syndrome Screening between Ultrasound-Based Gestational Age and Menstrual-Based Gestational Age by Maternal Serum Markers

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Pakorn Chaksuwat ◽  
Supatra Sirichotiyakul ◽  
Suchaya Luewan ◽  
Theera Tongsong
Keyword(s):  
Down Syndrome ◽  
Gestational Age ◽  
False Positive Rate ◽  
Serum Markers ◽  
Maternal Serum ◽  
Menstrual Period ◽  
Last Menstrual Period ◽  
Second Trimester Screening ◽  
Risk Categorization ◽  
Down Syndrome Screening

Objective. To evaluate the agreement of risk categorization for Down syndrome screening between ultrasound scan-based gestational age (GA) and last menstrual period-based gestational age in both first and second trimesters by maternal serum markers. Methods. Data comprising 4,055 and 4,016 cases of first and second trimester screening were used. The maternal serum markers were analyzed using the ultrasound-based GA and menstrual age. The subjects whose menstrual age and ultrasound-based GA fell in different trimesters were excluded because the risk could not be calculated due to the different serum markers used in each trimester. The agreement of risk categorization for fetal Down syndrome was evaluated. Results. The agreement of Down syndrome screening in the first and the second trimesters were 92.7% and 89%, respectively. The study found a good agreement of risk categorization by Kappa index, which was 0.615 for the overall screening. The menstrual age had a slight decrease in the detection rate and a lower false-positive rate. Conclusion. Menstrual age is acceptable in cases of accurate last menstrual period. However, in places where ultrasonography is not readily available, gestational age estimation by menstrual age along with clinical examination that corresponds to the gestational age can be reliable.

Relation between maternal weight and serum alpha-fetoprotein concentration during the second trimester.

1981 ◽  
Vol 27 (1) ◽  
pp. 133-134 ◽  
Author(s):  
J E Haddow ◽  
E M Kloza ◽  
G J Knight ◽  
D E Smith
Keyword(s):  
Body Weight ◽  
Pregnant Women ◽  
Reference Interval ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Second Trimester ◽  
Maternal Weight ◽  
Diagnostic Aid ◽  
Serum Alpha Fetoprotein ◽  
Clinical Interest

Abstract Maternal serum alpha-fetoprotein concentrations are influenced by maternal weight during the second trimester. Heavier pregnant women have lower median values, apparently as a result of a diluting effect of larger blood volume. This phenomenon is of clinical interest because alpha-fetoprotein concentration in a pregnant woman's serum is one of the factors considered in assessing risk of poor outcome. A revision of the reference interval for alpha-fetoprotein to take body weight into account might improve its use as a diagnostic aid, especially in heavier women.

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