Combining maternal serum alpha-fetoprotein measurements and age to screen for down syndrome in pregnant women under age 35

1989 ◽  
Vol 30 (3) ◽  
pp. 293-293
Author(s):  
GE Palomaki ◽  
J Williams ◽  
JE Haddow
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein

Relation between maternal weight and serum alpha-fetoprotein concentration during the second trimester.

1981 ◽  
Vol 27 (1) ◽  
pp. 133-134 ◽  
Author(s):  
J E Haddow ◽  
E M Kloza ◽  
G J Knight ◽  
D E Smith
Keyword(s):  
Body Weight ◽  
Pregnant Women ◽  
Reference Interval ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Second Trimester ◽  
Maternal Weight ◽  
Diagnostic Aid ◽  
Serum Alpha Fetoprotein ◽  
Clinical Interest

Abstract Maternal serum alpha-fetoprotein concentrations are influenced by maternal weight during the second trimester. Heavier pregnant women have lower median values, apparently as a result of a diluting effect of larger blood volume. This phenomenon is of clinical interest because alpha-fetoprotein concentration in a pregnant woman's serum is one of the factors considered in assessing risk of poor outcome. A revision of the reference interval for alpha-fetoprotein to take body weight into account might improve its use as a diagnostic aid, especially in heavier women.

Maternal serum alpha-fetoprotein screening for down syndrome: Economic considerations

1988 ◽  
Vol 31 (1) ◽  
pp. 231-245 ◽  
Author(s):  
J. Michael Swint ◽  
Frank Greenberg ◽  
John M. Opitz ◽  
James F. Reynolds ◽  
Frank Greenberg
Keyword(s):  
Down Syndrome ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein ◽  
Economic Considerations
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