Screening for gastrointestinal malignancy in patients with iron deficiency anemia by general practitioners: An observational study

2011 ◽  
Vol 46 (9) ◽  
pp. 1105-1110 ◽  
Author(s):  
Jolanda Droogendijk ◽  
Ruud Beukers ◽  
Paul B. Berendes ◽  
Martine G.H.M. Tax ◽  
Pieter Sonneveld ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Observational Study ◽  
General Practitioners ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Gastrointestinal Malignancy

MO557EFFICIENCY OF FERRIC CARBOXYMALTOSE IN NON-DIALYSIS CKD PATIENTS AND ITS IMPACT ON KIDNEY FUNCTION: A PROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Marisa Roldão ◽  
Rachele Escoli ◽  
Hernâni Gonçalves ◽  
Karina Lopes
Keyword(s):  
Iron Deficiency ◽  
Observational Study ◽  
Kidney Function ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Prospective Observational Study ◽  
Pearson Correlation ◽  
Deficiency Anemia ◽  
Ferric Carboxymaltose ◽  
Ckd Stage

Abstract Background and Aims Iron deficiency anemia occurs in the vast majority of patients with chronic kidney disease (CKD). The aim of this study was to investigate the efficacy of ferric carboxymaltose (FCM) iron deficiency anemia’s treatment in non-dialysis CKD patients and to clarify its impact on kidney function. Method Prospective observational study of non-dialysis CKD stage 3 to 5 patients, with anemia and iron deficiency treated with FCM from 01 January 2019 to 31 June 2020. FCM was administrated as a single IV infusion of 500mg or 1000mg. Baseline clinical, analytical and demographic data were recorded. FCM efficacy was evaluated by comparing hemoglobin (Hb), serum ferritin and transferrin saturation index (TSAT) 24 ± 8 weeks after the infusion with analytical values at baseline. Renal function was also assessed at baseline and at 24 ± 8 weeks using estimated glomerular filtration rate (eGFR), calculated by CKD-EPI formula. Statistical analysis was executed using SPSS (Version 23 for Mac OSX). Results The average age of 71 patients was 77.31 ± 9.68 years, 29 (40.8%) were male, 46 (64.8%) were diabetic and 41 (57.8%) had congestive heart failure. Sixteen (22.5%) patients had CKD stage 3, 41 (57.7%) stage 4 and 14 (19.7%) stage 5. Twenty-five (35.2%) patients were treated with 1000mg of FCM. At baseline, average hemoglobin level (Hb) was 10.16 ± 1.12g/dL, serum ferritin 83.25 ± 96.55µg/L, TSAT 14.48 ± 6.72mg/dL and eGFR 24.21± 13.09ml/min/1.73m2. At 24 ± 8 weeks, Hb showed an increase of 1.31 ± 1.49 g/dL (p=0.001) and TSAT 10.68 ± 10.40% (p=0.001). Serum ferritin showed also an increase of 4.75 ± 180.53µg/L but did not reach statistical significance. The increase in Hb was observed uniformly across all stages of CKD. A Pearson correlation revealed a positive correlation between the variation of Hb and eGFR during the study follow-up period (r=0.310, p=0.008). A subgroup analysis was performed, patients were classified in 2 groups according to FCM dose. At baseline, there was no age, comorbidities or eGFR difference among groups. Patients treated with 1000mg had lower Hb (p=0.03) and serum ferritin (p=0.01). At 24±8 weeks both groups showed increases in Hb (p=0.001) and TSAT (p=0.001). Patients treated with 1000mg showed also a significant increase in ferritin (p=0.004). The Pearson correlation confirmed a positive correlation between the variation of Hb and eGFR in the group of patients treated with 1000mg (r=0.467, p=0.019) but not in the group treated with 500mg. Conclusion FCM was effective in the treatment of iron deficiency anemia in non-dialysis CKD stage 3 to 5 patients. In our population, the increase of Hb levels correlated with an improvement in eGFR in patients treated with higher doses of FCM, suggesting a positive impact of FCM on kidney function.

scholarly journals Oral versus intravenous iron therapy in iron deficiency anemia: An observational study

2020 ◽  
Vol 9 (7) ◽  
pp. 3619
Author(s):  
PravatK Thatoi ◽  
SamarendraN Das ◽  
Amruta Devi ◽  
BibhutiB Mohanta ◽  
Anurag Choudhury ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Observational Study ◽  
Iron Deficiency Anemia ◽  
Intravenous Iron ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Intravenous Iron Therapy

Glossodynia, iron deficiency anemia, and gastrointestinal malignancy

1988 ◽  
Vol 65 (1) ◽  
pp. 130-133 ◽  
Author(s):  
F.J. Gallagher ◽  
D.L. Baxter ◽  
J. Denobile ◽  
G.M. Taybos
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Gastrointestinal Malignancy

scholarly journals Iron deficiency anaemia and its association with febrile seizures

2018 ◽  
Vol 5 (3) ◽  
pp. 1120
Author(s):  
Ramesh M. Nigade ◽  
Dhairyashil V. Khambalkar
Keyword(s):  
Iron Deficiency ◽  
Observational Study ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Research Centre ◽  
Age Group ◽  
Iron Deficient ◽  
Low Serum

Background: As reported by World Health Organization of total world’s population about 500 million to 2 billion people are deficient in iron. Iron deficiency is the most common hematological disease found in age group 6 months to 5 years. This age group generally coincides with the age group of occurrences of febrile seizures. Aim of this study was to study the role of iron deficiency in febrile seizures.Methods: This cross sectional, observational study done in the Pediatrics department of D. Y. Patil Hospital and Research Centre. 170 children of age group between 6months to 5 years will be included in the study over a period of 24 months from May 2015 to May 2017, Presenting with simple and complex febrile seizures to the emergency department and Pediatrics ward of hospital.Results: In the study the mean age of onset of febrile seizures is 21 months. Severity of anemia doesn’t have any correlation with occurrence of febrile seizures. Iron deficient in terms of low HB, low MCH, low MCV, high RDW, low serum Iron, high TIBC and low serum iron and TIBC ratio.Conclusions: From the current hospital based observational study we have concluded that, iron deficiency anemia was more frequent among children with febrile seizures. The result suggests that iron deficiency anemia may be a risk factor for febrile seizures screening for IDA should be considered in children with febrile seizures. All the investigations (Sr Iron, TIBC) carried out to evaluate iron deficiency anemia were significantly lower. This suggests that iron deficient children are more prone for febrile seizures.

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