Gallbladder cancer (GBC) is the 6th most common gastrointestinal
malignancy and most common hepatobiliary malignancy representing
85-90% worldwide with an annual incident of 2/1,00,000 and marked
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geographical and ethnic variability and known for late diagnosis and
poor outcome. High rates of gallbladder carcinoma are seen in
different parts of the world like South America (Chilli, Bolivia, and
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Ecuador) as well as in some parts of India (specically in north IndiaUP, Bihar, Delhi, West Bengal, Assam, and Madhya Pradesh, mostly in
Gangetic belt), Pakistan, Japan, and Korea. In north India, gallbladder
cancer is 10 times more common in comparison to south India. R
3 Kanthan et al . (2015) divides the risk factor for GBC into four broad
groups: i)Patient demography, ii) GB abnormalities, iii)patient
exposure to a specic chemical, genetic and molecular factors, iv)
Infection. This study says that not only gallbladder stones but also
infection by some microbial agents like salmonella and helicobacter
also having contributory risk factors