Influence of Bile Duct Occlusion on the Exocrine Pancreas in Rats

1985 ◽  
Vol 20 (9) ◽  
pp. 1065-1072 ◽  
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J. T. Holmberg ◽  
I. Ihse
1999 ◽  
Vol 67 (9) ◽  
pp. S577
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Juan Madariaga ◽  
Jorge Reyes ◽  
Rakesh Sindhi ◽  
Kareem Abu-Elmagd ◽  
George V. Mazariegos ◽  
...  

2003 ◽  
Vol 124 (4) ◽  
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Ulrich Toex ◽  
Ingo Scheller ◽  
Michael Andre Kern ◽  
Peter Schirmacher ◽  
Oliver Laue ◽  
...  

1986 ◽  
Vol 21 (1) ◽  
pp. 59-64 ◽  
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J. T. Holmberg ◽  
I. Ihse ◽  
I. Lundquist ◽  
B. Ahrén

2010 ◽  
Vol 21 (2) ◽  
pp. 289-294 ◽  
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Marcelo Guimaraes ◽  
Andre Uflacker ◽  
Claudio Schönholz ◽  
Renan Uflacker

2017 ◽  
Vol 40 (1) ◽  
pp. 104-107 ◽  
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Nobuaki Matsui ◽  
Rie Yoshioka ◽  
Asako Nozawa ◽  
Naonobu Kobayashi ◽  
Yukari Shichijo ◽  
...  

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Vol 18 (20) ◽  
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Yong-Zhong Zhao ◽  
Zhi-Ping Qi ◽  
Qing Xu ◽  
Xu-Hua Xiao ◽  
Fang Guo ◽  
...  

2008 ◽  
Vol 23 (suppl 1) ◽  
pp. 2-7 ◽  
Author(s):  
Miguel Angel Dias ◽  
Reginaldo Ceneviva ◽  
Jorge Elias Jr. ◽  
Sergio Zucoloto ◽  
Caroline Floreoto Baldo ◽  
...  

PURPOSE: To evaluate liver alterations caused by biliary obstruction and drainage. METHODS: Thirty-nine male Wistar rats were randomly distributed in 4 groups: BO (n=18) bile duct ligation for 20 days, with a periodic evaluation of liver histological alterations, Doppler echography portal flow and measurements of NO and malondialdehyde (MDA); BO/DB (n=13) bile duct occlusion for 20 days followed by biliary drainage by choledochoduodenal anastomosis, 5 days follow-up, same BO group parameters evaluations; group CED (n=4) sham operation and portal flow evaluation trough 20 days; CHB (n=4) sham operation, with hepatic biopsy on 25th day and followed-up trough 25 days, by the same parameters of group BO, with exception of portal flow. Direct bilirubin (DB) and alkaline phosphatase (AP) were evaluated in the group BO, BO/DB and CHB. RESULTS: The bile duct ligation led to an increase of DB and AP, development of liver histological alterations, reduction of portal flow and increase of plasmatic NO and of MDA levels. The bile duct clearing resulted in a reduction of DB, AP, NO, MDA histological alterations and increase of portal flow. CONCLUSION: The biliary occlusion resulted in cholestasis and portal flow reduction, besides the increase of plasmatic NO and of hepatic MDA levels, and histological liver alterations, with a tendency of normalization after the bile duct clearing.


Author(s):  
Shaima Abulqasim ◽  
Mohammad Arabi ◽  
Khalid Almasar ◽  
Bayan AlBdah ◽  
Refaat Salman

AbstractThis article aimed to assess the safety and effectiveness of biodegradable stents in the management of benign biliary strictures. This is a retrospective observational study that included all adult patients who had biodegradable stent placement for a benign cause of biliary stricture between July 2016 and August 2019. Nineteen patients were included. Seventeen patients had liver transplant. One patient had hepaticojejunostomy due to primary sclerosing cholangitis and one patient had iatrogenic left main bile duct occlusion. Stents were successfully deployed in all 19 patients (technical success: 100%). Patency rate was 90% (17/19) at 6 months and 80% (12/15) at 12 months. Seven patients in the study had stricture recurrence and needed reintervention with mean time to reintervention of 418 days (range: 8–1,155 days). There was one major complication due to cholangitis and sepsis, which required a treatment course with piperacillin/tazobactam for 10 days. No procedure-related pancreatitis or deaths occurred. Biodegradable stents are a safe and effective treatment option for benign biliary strictures and can achieve long-term patency without the need for reinterventions.


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