split liver transplantation
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2021 ◽  
Author(s):  
Mary G. Bowring ◽  
Allan B. Massie ◽  
Kathleen B. Schwarz ◽  
Andrew M. Cameron ◽  
Elizabeth A. King ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daisuke Ishii ◽  
Naoto Matsuno ◽  
Mikako Gochi ◽  
Hiroyoshi Iwata ◽  
Tatsuya Shonaka ◽  
...  

AbstractThis study examined the efficacy of end-ischemic hypothermic oxygenated machine perfusion preservation (HOPE) using an originally developed machine perfusion system for split-liver transplantation. Porcine split-liver grafts were created via 75% liver resection after 10 min of warm ischemia. In Group 1, grafts were preserved by simple cold storage (CS) for 8 h (CS group; n = 4). In Group 2, grafts were preserved by simple CS for 6 h and end-ischemic HOPE for 2 h (HOPE group; n = 5). All grafts were evaluated using an isolated ex vivo reperfusion model with autologous blood for 2 h. Biochemical markers (aspartate aminotransferase and lactate dehydrogenase levels) were significantly better immediately after reperfusion in the HOPE group than in the CS group. Furthermore, the HOPE group had a better histological score. The levels of inflammatory cytokines (tumor necrosis factor-α, interferon-γ, interleukin-1β, and interleukin-10) were significantly lower after reperfusion in the HOPE group. Therefore, we concluded that end-ischemic HOPE for split-liver transplantation can aid in recovering the graft function and reducing ischemia–reperfusion injury. HOPE, using our originally developed machine perfusion system, is safe and can improve graft function while attenuating liver injury due to preservation.


2021 ◽  
Author(s):  
Dimitri Sneiders ◽  
Anne‐Baue R.M. van Dijk ◽  
Wojciech G. Polak ◽  
Darius F. Mirza ◽  
M. Thamara P.R. Perera ◽  
...  

Medicine ◽  
2021 ◽  
Vol 100 (39) ◽  
pp. e27369
Author(s):  
Kun-Ming Chan ◽  
Hao-Chien Hung ◽  
Jin-Chiao Lee ◽  
Tsung-Han Wu ◽  
Yu-Chao Wang ◽  
...  

2021 ◽  
Vol 7 (8) ◽  
pp. e735
Author(s):  
Ngee-Soon Lau ◽  
Ken Liu ◽  
Abdullah Almoflihi ◽  
Josephine Xu ◽  
Geoffrey McCaughan ◽  
...  

2021 ◽  
Vol 105 (8) ◽  
pp. e89-e90
Author(s):  
Jean-Yves Mabrut ◽  
Mickaël Lesurtel ◽  
Xavier Muller ◽  
Rémi Dubois ◽  
Christian Ducerf ◽  
...  

2021 ◽  
pp. medethics-2021-107400
Author(s):  
Tae Wan Kim ◽  
John Roberts ◽  
Alan Strudler ◽  
Sridhar Tayur

Split liver transplantation (SLT) provides an opportunity to divide a donor liver, offering transplants to two small patients (one or both could be a child) rather than keeping it whole and providing a transplant to a single larger adult patient. In this article, we attempt to address the following question that is identified by the Organ Procurement and Transplant Network and United Network for Organ Sharing: ‘Should a large liver always be split if medically safe?’ This article aims to defend an answer—‘not always’—and clarify under what circumstances SLT is ethically desirable. Our answer will show why a more dynamic approach is needed to the ethics of SLT. First, we discuss a case that does not need a dynamic approach. Then, we explain what is meant by a dynamic approach and why it is needed.


2021 ◽  
pp. 100627
Author(s):  
Ngee-Soon Lau ◽  
Andrew Jacques ◽  
Geoffrey McCaughan ◽  
Michael Crawford ◽  
Ken Liu ◽  
...  

2021 ◽  
Vol 35 (1) ◽  
pp. 66-70
Author(s):  
Jung-Man Namgoong ◽  
Shin Hwang ◽  
Dae-Yeon Kim ◽  
Tae-Yong Ha ◽  
Gi-Won Song ◽  
...  

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