Protective Effects of Calcium Channel Blockers on Acute Bromobenzene Toxicity to Isolated Rat Hepatocytes Inhibition of Phenylephrine-Induced Calcium Oscillations

1995 ◽  
Vol 30 (6) ◽  
pp. 590-600 ◽  
Author(s):  
J. Wu ◽  
Å. Danielsson ◽  
P. Lindström ◽  
K. Karlsson ◽  
J. Sehlin
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Rat Hepatocytes ◽  
Calcium Oscillations ◽  
Channel Blockers ◽  
Protective Effects ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes

2004 ◽  
Vol 56 (11) ◽  
pp. 1469-1474 ◽  
Author(s):  
S. Bohlooli ◽  
M. Mahmoudian ◽  
G. G. Skellern ◽  
M. H. Grant ◽  
J. N. A. Tettey
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Rat Hepatocytes ◽  
Channel Blockers ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

scholarly journals Protective Effects of Saponin Mixture, Isolated from <i>Astragalus monspessulanus</i> subsp. <i>monspessulanus</i> on Tert-Butyl Hydroperoxide—Induced Oxidative Stress in Isolated Rat Hepatocytes

2015 ◽  
Vol 06 (06) ◽  
pp. 799-803 ◽  
Author(s):  
Magdalena Spasova Kondeva-Burdina ◽  
Viktor Bratkov ◽  
Rumyana Lubomirova Simeonova ◽  
Vessela Bisserova Vitcheva ◽  
Ilina Nikolaeva Krasteva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hepatocytes ◽  
Protective Effects ◽  
Isolated Rat Hepatocytes ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Isolated Rat

The protective effects of melanoidins in adriamycin-induced oxidative stress in isolated rat hepatocytes

2004 ◽  
Vol 84 (13) ◽  
pp. 1701-1707 ◽  
Author(s):  
V Valls-Bellés ◽  
MC Torres ◽  
P Muñiz ◽  
L Boix ◽  
ML González-Sanjose ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hepatocytes ◽  
Protective Effects ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

Protective effects of calcium channel blockers on hydrogen peroxide induced increases in endothelial permeability

1990 ◽  
Vol 24 (12) ◽  
pp. 993-997 ◽  
Author(s):  
Y. Yamada ◽  
M. Yokota ◽  
T. Furumichi ◽  
H. Furui ◽  
K. Yamauchi ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Endothelial Permeability ◽  
Channel Blockers ◽  
Protective Effects

scholarly journals Cytoprotective Effects of Taurine Against Toxicity Induced by Isoniazid and Hydrazine in Isolated Rat Hepatocytes

2013 ◽  
Vol 64 (2) ◽  
pp. 201-210 ◽  
Author(s):  
Reza Heidari ◽  
Hossein Babaei ◽  
Mohammad Ali Eghbal
Keyword(s):  
Lipid Peroxidation ◽  
Rat Hepatocytes ◽  
Toxic Metabolite ◽  
Protective Effects ◽  
Isolated Rat Hepatocytes ◽  
Intermediary Metabolite ◽  
Ros Formation ◽  
Membrane Depolarisation ◽  
Antioxidative Action ◽  
Isolated Rat

Isoniazid is one of the most commonly used drugs to treat tuberculosis. Its administration is associated with a high incidence of hepatotoxicity. The aim of this study was to establish the protective effects of taurine against cytotoxicity induced by isoniazid and its suspected toxic metabolite hydrazine in isolated rat hepatocytes by measuring reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial depolarisation, reduced glutathione (GSH), and oxidised glutathione (GSSG). Isoniazid caused no significant ROS formation in normal hepatocytes, but in glutathione-depleted cells it was considerable. Hydrazine caused ROS formation and lipid peroxidation in both intact and glutathione-depleted cells. Both isoniazid and hydrazine caused mitochondrial membrane depolarisation. Hydrazine lowered cellular GSH reserve and increased GSSG. Taurine (200 μmol L-1) and N-acetylcysteine (200 μmol L-1) effectively countered the toxic effects of isoniazid and/or hydrazine by decreasing ROS formation, lipid peroxidation, and mitochondrial damage. Taurine prevented depletion of GSH and lowered GSSG levels in hydrazine-treated cells. This study suggests that the protective effects of taurine against isoniazid and its intermediary metabolite hydrazine cytotoxicity in rat hepatocytes could be attributed to antioxidative action.

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