Classic Triad of Ross Syndrome with Diffuse Autonomic Dysfunction and Positive Antinuclear Antibody Titre

Rowell’s syndrome is a rare disorder characterised by an association of lupus erythematosus with erythema multiforme (EM)-like skin lesions. EM as the initial clinical presentation of systemic lupus erythematosus is also atypical and even rarer. We report the case of an 18-year-old girl admitted to our hospital with fever and polyarthralgia along with multiple discrete ill-defined target lesions with crust formation over forehead, cheek, external ears, scalp, upper chest and back (predominantly over sun-exposed areas) with ulceration over hard palate. Investigations revealed pancytopaenia, a positive rheumatoid factor, positive antinuclear antibody with a speckled pattern, anti-Smith antibody and strongly positive anti-Ro. Patient was diagnosed with Rowell’s syndrome as per clinical and laboratory features. Majority of skin lesions including oral ulcerations subsided gradually after treatment with steroids and hydroxychloroquine.

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Antinuclear antibody determinations in Ro(SSA)-positive, antinuclear antibody—negative lupus and Sjögren's syndrome patients

Journal of the American Academy of Dermatology ◽

10.1016/s0190-9622(83)70065-4 ◽

1983 ◽

Vol 8 (5) ◽

pp. 611-615 ◽

Cited By ~ 9

Author(s):

Normand Doré ◽

Daniel Synkowski ◽

Thomas T. Provost

Keyword(s):

Sjögren’S Syndrome ◽

Antinuclear Antibody ◽

Sjögren's Syndrome ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Positive Antinuclear Antibody ◽

Sjögren‘S Syndrome

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Autoinflammatory/Autoimmunity Syndrome Induced By Adjuvants (ASIA) Due to Silicone Incompatibility Syndrome

Case Reports in Rheumatology ◽

10.1155/2021/5595739 ◽

2021 ◽

Vol 2021 ◽

pp. 1-4

Author(s):

Genessis Maldonado ◽

Roberto Guerrero ◽

Maria Intriago ◽

Carlos Rios

Keyword(s):

Hyaluronic Acid ◽

Antinuclear Antibody ◽

Liquid Paraffin ◽

Adaptive Immune System ◽

Chemical Compounds ◽

Anticentromere Antibody ◽

Adaptive Immune ◽

Breast Prosthesis ◽

Autoimmune Syndrome ◽

Positive Antinuclear Antibody

The adjuvant-induced autoimmune syndrome (ASIA) is associated with a dysregulation of the innate and adaptive immune system after exposure to chemical compounds, including liquid paraffin, silicone gel, acrylamides, and hyaluronic acid. Due the increase of the use of these compounds in cosmetic procedures, the prevalence of this syndrome is increasing. We present the first report in Ecuador associated to ASIA after an elective silicone breast prosthesis procedure, manifested as polyarthralgia, positive antinuclear antibody, anticentromere antibody, and a moderate positive Sclero-70.

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Pyoderma Gangrenosum with Positive Antinuclear Antibody, in the Absence of Systemic Association

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v16i1.19418 ◽

2018 ◽

Vol 16 (1) ◽

pp. 66-69

Author(s):

Smriti Shrestha ◽

Alisha Aryal

Keyword(s):

Pyoderma Gangrenosum ◽

Lupus Erythematosus ◽

Antinuclear Antibody ◽

Case Reports ◽

Neutrophilic Dermatosis ◽

Systemic Diseases ◽

Connective Tissue Disorders ◽

Systemic Lupus ◽

Unique Case ◽

Positive Antinuclear Antibody

Pyoderma gangrenosum is an uncommon neutrophilic dermatosis, seen on legs, and infrequently on hands and other anatomical sites. It is associated with systemic diseases in 50-70% of the cases. Antinuclear antibody (ANA) seropositivity has been reported in pyoderma gangrenosum associated with connective tissue disorders. However, there are very few case reports of pyoderma gangrenosum in patients of systemic lupus erythematosus, while we did not find any reports of ANA seropositivity in isolated pyoderma gangrenosum. Hence, we report this unique case of pyoderma gangrenosum with classical clinicohistopathology, positive ANA but no systemic association. As anticipated, our patient responded promptly to steroids.

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Screening for autoantibodies to SS-A/Ro by indirect immunofluorescence using HEp-2000TM cells

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1258/0004563001899032 ◽

2000 ◽

Vol 37 (2) ◽

pp. 216-219 ◽

Cited By ~ 9

Author(s):

Xavier Bossuyt ◽

Lisette Meurs ◽

Alex Mewis ◽

Godelieve Mariën ◽

Norbert Blanckaert

Keyword(s):

Antibody Titre ◽

Indirect Immunofluorescence ◽

Antinuclear Antibody ◽

Staining Pattern ◽

Fluorescence Staining ◽

Transfected Cells

We evaluated indirect immunofluorescence (IF) using HEp-2000TM slides, which are transfected with SS-A cDNA, for screening for anti-SS-A antibodies, by comparing it with counterimmunoelectrophoresis (CIE). A total of 2427 specimens were screened for IF reactivity and for SS-A precipitins, of which 1033 (43%) were negative on both IF and CIE. There were 1271 SS-A precipitin-negative specimens (52%) which were IF-positive but lacked the distinctive SS-A staining pattern. One precipitin-negative serum was IF-positive with the distinctive SS-A pattern in the HEp-2000 system. One hundred and twenty-two specimens (5%) were positive for anti-SS-A precipitins on CIE, 107 showed the distinctive SS-A fluorescence staining pattern, whereas 15 of these precipitin-positive samples (12%) were IF-positive but did not display the distinctive SS-A pattern on the transfected cells. Fourteen of the 15 samples in which the distinctive SS-A pattern was not observed displayed other significant antinuclear antibody (titre equal or > 1:320 patterns. In conclusion, the presence of the typical 'distinctive' SS-A pattern on IF using the HEp-2000 slides is highly specific for the presence of autoantibodies to SS-A and has a sensitivity of 88% for detecting these antibodies.

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