Backgroud The long-term outcomes of this combined procedure remain
elusive. This meta-analysis aimed to assess the long-term efficacy and
safety of combined procedure. Methods PubMed, Embase, Cochrane Library,
and Web of Science were systematically searched from the establishment
of databases to 1 January 2021. Studies on the long-term (defined as a
mean follow-up of approximately 12 months or longer) efficacy and safety
outcomes of combined ablation and LAAC were included for meta-analysis.
Results A total of 16 studies comprising 1,428 patients were included in
the meta-analysis. The pooled long term freedom rate from atrial
arrhythmia was 0.66 (95% confidence interval [CI], 0.59-0.71),
long-term successful rate sealing of LAAC was 1.00 (95% CI, 1.00-1.00),
and ischemic stroke/transient ischemic attack/systemic embolism during
follow-up was 0.01 (95% CI, 0.00-0.02). Meanwhile, the rates of
peri-procedural adverse events included phrenic nerve palsy,
intracoronary air embolus, device embolization, peri-procedural death of
0.00 (95% CI, 0.00-0.00), procedure-related bleeding events of 0.03
(95% CI, 0.02-0.04), and pericardial effusion requiring or not
requiring intervention of 0.00 (95% CI, 0.00-0.01). Moreover, the rates
of long-term adverse events rate included device dislocation,
intracranial bleeding, and pericardial effusion requiring or not
requiring intervention, and all-cause mortality of 0.00 (95% CI,
0.00-0.00), device embolization of 0.01 (95% CI, 0.00-0.01), and other
bleeding events of 0.01 (95% CI, 0.00-0.03). Conclusion This
meta-analysis suggests that the strategy of combined atrial ablation and
LAAC is effective and safe during long-term follow-up
Meta-Analysis of the Efficacy and Safety of Bronchial Thermoplasty in Patients with Moderate-To-Severe Persistent Asthma