Irritable Bowel Syndrome in Renal Transplant Patients: Prevalence, Link with Quality of Life, Anxiety, and Depression

AbstractIntroductionIrritable Bowel Syndrome (IBS) is a functional and multifactorial gastrointestinal disorder characterized by pain, abdominal distention and motility changes, currently diagnosed based on the Rome IV criteria. The efficacy of classic pharmacological, psychological and dietary treatments for this condition are generally low. The Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) are short chain carbohydrates poorly absorbed at the intestinal level, fermentable by the microbiota and presumably involved in IBS-associated symptomatology.AimsTo evaluate the efficacy, feasibility and acceptability of a FODMAP-restricted feeding approach in the relief of symptomatology and in the improvement of the quality of life of patients with IBS, determining the reintroduction of the FODMAP food subgroup(s) involved in the symptom exacerbation.Materials and MethodsAfter assessing the existence of initial emotional disorders through the Hospital Anxiety and Depression Scale (HADS) and eating habits, through dietary history, patients diagnosed with IBS were put on a FODMAP-restricted diet for 6 weeks. During this period, the weekly evolution of symptom frequency was assessed. At the end, tests were undertaken to discover the global evolution of the symptoms through the Irritable Bowel Syndrome - Global Assessment Scale (IBS-GAI), the severity of symptomatology through the Irritable Bowel Syndrome - Severity Scoring System (IBS-SSS) and quality of life through Irritable Bowel Syndrome - Quality of Life (IBS-QoL).Subsequently, participants tested their tolerance to various FODMAP subtypes with weekly and isolated reintroduction of these in their diet.ResultsIn the 36 participants, with a mean age of 38.8 years, there was a reduction in the total consumption of FODMAP from 22.1 g to 2.1 g (p < 0.001). A moderate or substantial improvement in the IBS-GAI was observed in 88.9%. An average reduction of 235 points in the IBS-SSS (p < 0.001) and a mean increase of 28.7 in the IBS-QoL (p < 0.001) was achieved. The initial anxiety and depression levels were not associated with IBS-SSS and presented an inverse association with the IBS-QoL. There was significant improvement in all symptomatology during the 1st week of total FODMAP restriction, except for constipation with an amelioration observed at the 6st week. There was a frequency of intolerance ranging from 30.8% for fructans to 80.8% for lactose with the reintroduction of the FODMAP subtypes.ConclusionA FODMAP-restricted diet, implemented over a period of 6 weeks, is effective in reducing the severity and frequency of GI symptoms and improving the quality of life of portuguese patients with IBS.

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Renal transplant patients have a good quality of life

Drugs & Therapy Perspectives ◽

10.2165/00042310-199811080-00006 ◽

1998 ◽

Vol 11 (8) ◽

pp. 13-16

Author(s):

&NA;

Keyword(s):

Quality Of Life ◽

Renal Transplant ◽

Transplant Patients ◽

Renal Transplant Patients

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Burden, coping mechanisms, and quality of life among caregivers of hemodialysis and peritoneal dialysis undergoing and renal transplant patients

Indian Journal of Psychiatry ◽

10.4103/psychiatry.indianjpsychiatry_401_18 ◽

2019 ◽

Vol 61 (4) ◽

pp. 380

Author(s):

SA A Latheef ◽

M Nagarathnam ◽

Vishnubotla Sivakumar

Keyword(s):

Quality Of Life ◽

Peritoneal Dialysis ◽

Renal Transplant ◽

Coping Mechanisms ◽

Transplant Patients ◽

Renal Transplant Patients

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Comparison of quality of life between haemodialysis and renal transplant patients

Connect The World of Critical Care Nursing ◽

10.1891/1748-6254.6.4.69 ◽

2008 ◽

Vol 6 (4) ◽

pp. 69-72 ◽

Cited By ~ 1

Author(s):

Sedigheh Fayazi ◽

Marziyeh Asadizaker ◽

Athary Shahrouz

Keyword(s):

Quality Of Life ◽

Renal Transplant ◽

Transplant Patients ◽

Renal Transplant Patients

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The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors

Microbial Cell Factories ◽

10.1186/s12934-021-01720-1 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Hao Lin ◽

Qingqing Guo ◽

Zhiyong Wen ◽

Songlin Tan ◽

Jie Chen ◽

...

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Rating Scale ◽

Isovaleric Acid ◽

Valeric Acid ◽

Metagenomic Analysis ◽

Anxiety And Depression ◽

Bacterial Invasion ◽

Irritable Bowel

Abstract Background Anxiety and depression are complications in Irritable bowel syndrome (IBS) patients. In this study, we recruited 18 IBS patients with mild-modest anxiety and depression behaviors, and after the screening, we defined the FMT treatment group (n = 9) and the control group (n = 9). The IBS symptom severity scale (IBS-SSS), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D), Irritable Bowel Syndrome Quality of Life (IBS-QOL) and Bristol stool scale (BSS) were evaluated one week before FMT (baseline), one-week-, one-month-, two-month-, and three-month-following FMT. Meanwhile, we determined the SCFAs in the patient’s feces and serum and continued the metagenomic analysis of the microorganisms in the patient’s feces. Results The results showed that the patient’s anxiety and depression behavior gradually improved with FMT treatment. Moreover, the illness and quality of life had also been relieved significantly. The content of isovaleric acid and valeric acid was significantly reduced in the FMT group compared to the Col group. Metagenomic analysis showed that FMT treatment decreased the abundance of Faecalibacterium, Eubacterium and Escherichia. From KEGG functional analysis, we confirmed that the top five abundant pathways were “bacterial chemotaxis, “flagellar assembly”, “glycine, serine and threonine metabolism”, “apoptosis”, and “bacterial invasion of epithelial cells”. Conclusions FMT treatment can effectively alleviate the anxiety and depression behaviors of IBS-D patients and reduce the IBS-SSS score, indicating that FMT can improve patients’ symptoms. The high throughput sequencing results show that Bifidobacterium and Escherichia play the most critical role in the formation and recovery of IBS-D patients. The GC/MS data indicated that faeces isovaleric acid and valeric acid might be more suitable as a metabolic indicator of IBS-D remission. Trial registration ChiCTR, ChiCTR1900024924, Registered 3 August 2019, https://www.chictr.org.cn/showproj.aspx?proj=41676.

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