Antibodies to Phosphatidylethanolamine in Antiphospholipid Syndrome and Systemic Lupus Erythematosus: Their Correlation with Anticardiolipin Antibodies and P2Glycoprotein-I Plasma Levels

Autoimmunity ◽  
1993 ◽  
Vol 16 (4) ◽  
pp. 245-249 ◽  
Author(s):  
P. G. Vlachoyiannopoulos ◽  
G. Beigbeder ◽  
M. Dueymes ◽  
P. Youinou ◽  
J. E. Hunt ◽  
...  
1994 ◽  
Vol 108 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Tim Vyse ◽  
Linda M. Luxon ◽  
Mark J. Walport

AbstractWe report on two patients who have high titres of antiphospholipid antibodies, both of whom had acute audiovestibular failure. One of the patients had systemic lupus erythematosus. The other patient had primary antiphospholipid syndrome: audiovestibular symptoms have not been reported in this condition. The occurrence of acute audiovestibular failure in the primary antiphospholipid syndrome raises the question as to whether patients presenting with acute deafness or vestibular disturbance should be screened for the presence of anticardiolipin antibodies.


1995 ◽  
Vol 5 (11) ◽  
pp. 1882-1887
Author(s):  
V R Peddi ◽  
K S Kant

The association between thrombotic events and primary or secondary antiphospholipid/anticardiolipin syndrome is now well recognized. A spectrum of renal involvement ranging from glomerular thrombosis to renal infarction has been described. A case of systemic lupus erythematosus with immunoglobulin G and M antiphospholipid/anticardiolipin antibodies is reported. The patient developed catastrophic thrombosis in multiple organs, and glomerular thrombosis was documented by renal biopsy. The patient had an acquired antithrombin III deficiency, and the combination of secondary antiphospholipid syndrome with accompanying antithrombin III deficiency predisposed to thrombosis. Several mechanisms by which antiphospholipid/anticardiolipin antibodies cause thrombosis have been proposed and are briefly reviewed.


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