Autologous whole blood and autologous serum injections are equally effective as placebo injections in reducing disease activity in patients with chronic spontaneous urticaria: a placebo controlled, randomized, single-blind study

2011 ◽  
Vol 23 (6) ◽  
pp. 465-471 ◽  
Author(s):  
Emek Kocatürk ◽  
Selin Aktaş ◽  
Zafer Türkoğlu ◽  
Mukaddes Kavala ◽  
Ilkin Zindanci ◽  
...  
Keyword(s):  
Disease Activity ◽  
Whole Blood ◽  
Chronic Spontaneous Urticaria ◽  
Blind Study ◽  
Autologous Serum ◽  
Autologous Whole Blood ◽  
Single Blind

Autologous Whole Blood Injections to Patients with Chronic Urticaria and a Positive Autologous Serum Skin Test: A Placebo-Controlled Trial

Dermatology ◽  
2006 ◽  
Vol 212 (2) ◽  
pp. 150-159 ◽  
Author(s):  
P. Staubach ◽  
K. Onnen ◽  
A. Vonend ◽  
M. Metz ◽  
F. Siebenhaar ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Whole Blood ◽  
Controlled Trial ◽  
Autologous Serum ◽  
Autologous Serum Skin Test ◽  
Autologous Whole Blood

scholarly journals Autologous Whole-blood Injections in Chronic Spontaneous Urticaria: Assessment of Efficacy Biomarkers

2020 ◽  
Author(s):  
Nikolaos Aggelis Kitsioulis ◽  
Efterpi Zafiriou ◽  
Paraskevi Xepapadaki ◽  
Styliani Taka ◽  
Nikolaos G. Papadopoulos ◽  
...  
Keyword(s):  
Whole Blood ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Whole Blood

There is no Abstract.

scholarly journals What Basophil Testing Tells Us About CSU Patients – Results of the CORSA Study

2021 ◽  
Vol 12 ◽  
Author(s):  
João Marcelino ◽  
Katrine Baumann ◽  
Per Stahl Skov ◽  
Maria Conceição Pereira Santos ◽  
Inga Wyroslak ◽  
...  
Keyword(s):  
Disease Activity ◽  
Poor Response ◽  
Basophil Activation Test ◽  
Cross Sectional Study ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Total Serum ◽  
Thyroid Autoantibodies ◽  
Cross Sectional ◽  
Autologous Serum Skin Test

Basophil testing is the most effective single approach for diagnosing type-IIb autoimmune chronic spontaneous urticaria (TIIbaiCSU). A positive basophil test has been linked to long disease duration, higher disease activity, a poor response to antihistamines and omalizumab, and a better response to cyclosporine and fenebrutinib. As of now it is unclear what other features are connected to a positive basophil test in chronic spontaneous urticaria (CSU). We aimed to identify features of basophil test-positive CSU patients. We performed a cross-sectional study of 85 CSU patients. Basophil testing was done with the basophil activation test (BAT) and the basophil histamine release assay (BHRA). Data were analysed using SPSS: Student’s t-test, Chi-square test, Odds Ratio, Spearman’s correlation test. Of 85 CSU patients, 44% and 28% tested positive with the BAT and BHRA, respectively. These patients showed higher disease activity and impact, lower levels of disease control and total serum IgE, as well as higher rates of having a positive autologous serum skin test (ASST), angioedema, nocturnal symptoms, symptoms for >5 days/week, and thyroid autoantibodies. The ASST, by itself, was not a good predictor of basophil test results, but it predicted a positive basophil test in up to 100% of cases when combined with angioedema, thyroid autoantibodies or low IgE. In conclusion, a positive basophil test is linked to known features of TIIbaiCSU and novel characteristics including nocturnal symptoms. Further studies on basophil test-positive and -negative CSU patients can help to better understand CSU endotypes and to develop better management approaches.

Effectiveness of Autologous Whole-Blood Injections in Patients with Refractory Chronic Spontaneous Urticaria

2017 ◽  
Vol 172 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Nikolaos Aggelis Kitsioulis ◽  
Paraskevi Xepapadaki ◽  
Aggeliki-Victoria Roussaki-Schulze ◽  
Nikolaos Papadopoulos ◽  
Efterpi Zafiriou
Keyword(s):  
Whole Blood ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Whole Blood

scholarly journals Autologous whole-blood or autologous serum acupoint injection therapy for chronic urticaria

Medicine ◽  
2019 ◽  
Vol 98 (25) ◽  
pp. e16127 ◽  
Author(s):  
Leixiao Zhang ◽  
Xianjun Xiao ◽  
Ruting Hui ◽  
Yunzhou Shi ◽  
Yanli Deng ◽  
...  
Keyword(s):  
Chronic Urticaria ◽  
Whole Blood ◽  
Injection Therapy ◽  
Autologous Serum ◽  
Acupoint Injection ◽  
Autologous Whole Blood

scholarly journals Autologous Whole Blood Injection for the Treatment of Antihistamine-Resistant Chronic Spontaneous Urticaria

2015 ◽  
Vol 27 (6) ◽  
pp. 784 ◽  
Author(s):  
Hyang-Suk You ◽  
Hyun-Ho Cho ◽  
Won-Jeong Kim ◽  
Je-Ho Mun ◽  
Margaret Song ◽  
...  
Keyword(s):  
Whole Blood ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Whole Blood ◽  
Blood Injection

Influence of Vitamin E on Plasma Malondialdehyde- Like Material in Man

1984 ◽  
Vol 51 (03) ◽  
pp. 347-348 ◽  
Author(s):  
C Cordova ◽  
A Musca ◽  
F Violi ◽  
C Alessandri ◽  
A Ghiselli ◽  
...  
Keyword(s):  
Vitamin E ◽  
Healthy Subjects ◽  
Placebo Treatment ◽  
Blind Study ◽  
Single Blind ◽  
Plasma Malondialdehyde

SummaryThe behaviour of plasma malondialdehyde-like material (MDA-LM) was evaluated in 13 healthy subjects by a single-blind study that consisted of placebo (30 days), vitamin E treatment (300 mg/day) (30 days) and placebo (30 days). The study demonstrated that MDA-LM did not change during placebo treatment while it significantly decreased after vitamin E administration.

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