scholarly journals What Basophil Testing Tells Us About CSU Patients – Results of the CORSA Study

2021 ◽  
Vol 12 ◽  
Author(s):  
João Marcelino ◽  
Katrine Baumann ◽  
Per Stahl Skov ◽  
Maria Conceição Pereira Santos ◽  
Inga Wyroslak ◽  
...  
Keyword(s):  
Disease Activity ◽  
Poor Response ◽  
Basophil Activation Test ◽  
Cross Sectional Study ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Total Serum ◽  
Thyroid Autoantibodies ◽  
Cross Sectional ◽  
Autologous Serum Skin Test

Basophil testing is the most effective single approach for diagnosing type-IIb autoimmune chronic spontaneous urticaria (TIIbaiCSU). A positive basophil test has been linked to long disease duration, higher disease activity, a poor response to antihistamines and omalizumab, and a better response to cyclosporine and fenebrutinib. As of now it is unclear what other features are connected to a positive basophil test in chronic spontaneous urticaria (CSU). We aimed to identify features of basophil test-positive CSU patients. We performed a cross-sectional study of 85 CSU patients. Basophil testing was done with the basophil activation test (BAT) and the basophil histamine release assay (BHRA). Data were analysed using SPSS: Student’s t-test, Chi-square test, Odds Ratio, Spearman’s correlation test. Of 85 CSU patients, 44% and 28% tested positive with the BAT and BHRA, respectively. These patients showed higher disease activity and impact, lower levels of disease control and total serum IgE, as well as higher rates of having a positive autologous serum skin test (ASST), angioedema, nocturnal symptoms, symptoms for >5 days/week, and thyroid autoantibodies. The ASST, by itself, was not a good predictor of basophil test results, but it predicted a positive basophil test in up to 100% of cases when combined with angioedema, thyroid autoantibodies or low IgE. In conclusion, a positive basophil test is linked to known features of TIIbaiCSU and novel characteristics including nocturnal symptoms. Further studies on basophil test-positive and -negative CSU patients can help to better understand CSU endotypes and to develop better management approaches.

scholarly journals Quality of Life Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients

2021 ◽  
Vol 4 (1) ◽  
pp. 24-29
Author(s):  
Mahvira Chow Liana Herman Adil ◽  
Nopriyati Nopriyati ◽  
Desi Oktariana ◽  
Yuli Kurniawati ◽  
Gita Dwi Prasasty
Keyword(s):  
Quality Of Life ◽  
Skin Test ◽  
Outpatient Clinic ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Bivariate Analysis ◽  
Female Group ◽  
Cross Sectional ◽  
Autologous Serum Skin Test

Several studies regarding the quality of life of chronic spontaneous urticaria patients based on Autologous Serum Skin Test (ASST) results have shown a variety of results. This study aims to determine the correlation between the quality of life and ASST results in chronic spontaneous urticaria patients at Dermatology and Venereology (DV) Outpatient Clinic of Dr. Mohammad Hoesin Hospital Palembang. This analytic observational study with a cross-sectional design used secondary data in the form of medical records. 76 samples met the inclusion criteria from 110 samples of chronic spontaneous urticaria patients at DV outpatient clinic. The distribution of chronic spontaneous urticaria patients was highest in the 17-25 year age group (23.7%) and the female group (64.5%). The majority of chronic spontaneous urticaria patients had negative ASST results (52.6%). The effect of chronic spontaneous urticaria on the decline in quality of life was mostly moderate (35.5%). The bivariate analysis between DLQI score and ASST results with a value of p = 0.307 or p> 0.05 showed no significant correlation between the quality of life and ASST results.

scholarly journals Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Aysegul Alpay ◽  
Nilgün Solak Tekin ◽  
Ishak Özel Tekin ◽  
H. Cevdet Altinyazar ◽  
Rafet Koca ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Thyroid Autoantibodies ◽  
Thyroid Function Tests ◽  
Control Groups ◽  
Autologous Plasma ◽  
Autologous Serum Skin Test ◽  
Autoimmune Urticaria ◽  
And Control

Previous studies indicate that 25–45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU) and 50 sex- and age-matched healthy individuals aged 18 years, and older. A total of 31 (62%) patients and 5 (10%) control patients had positive ASST; 21 (42%) patients and 3 (6%) control patients had positive APST. Statistically significant differences were noted in ASST and APST positivity between the patient and control groups (ASSTP<0.001; APSTP<0.001). Thirteen (26%) patients and 5 (10%) control patients had antithyroglobulin antibodies or antithyroid peroxidase antibody positivity. No statistically significant differences were noted in thyroid autoantibodies between the patient and control groups (anti-TGP=0.317; anti-TPOP=0.269). We consider that the ASST and APST can both be used asin vivotests for the assessment of autoimmunity in the etiology of CSU and that thyroid autoantibodies should be checked even when thyroid function tests reveal normal results in patients with CSU.

scholarly journals Autologous serum skin test and skin prick test in patients with chronic urticaria: a cross sectional study

2017 ◽  
Vol 3 (1) ◽  
pp. 46
Author(s):  
Mounika K. ◽  
Shivaswamy K. N.
Keyword(s):  
Skin Prick Test ◽  
Skin Test ◽  
Cross Sectional Study ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Chi Square ◽  
Cross Sectional ◽  
Autologous Serum Skin Test ◽  
Prick Test ◽  
History Of

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Urticaria is an allergic skin disorder characterized by wheals. Though the diagnosis is easy, it is difficult to identify the cause for the episodes. Autologous serum skin test (ASST) and skin prick test (SPT) help in the identification of the cause. The objective of the study was to determine the frequency of ASST and SPT positivity in patients with chronic idiopathic urticaria (CIU).</span></p><p class="abstract"><strong>Methods:</strong> Fifty-six patients attending the dermatology OPD with chronic idiopathic urticaria were evaluated and taken up for the study. ASST and SPT were performed on all the patients and the obtained results were documented. Data was analyzed using Chi square test.<strong></strong></p><p class="abstract"><strong>Results:</strong> Among the 56 patients studied, males (53.57%) outnumbered females and the majority was in the age group 21 to 30 years (33.9%). One third of the study patients gave history of known food allergy and 10.7% gave history of dust allergy. ASST positivity was seen in 30.3% and SPT positivity was seen in 64.3%. Ten of our patients (17.8%) were positive to both ASST and SPT. Amongst the SPT positives 33.3% showed positivity to food allergens, 19.4% showed positivity to aeroallergens and 47.2% showed positivity to both<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> ASST and SPT are two reliable tools in identifying the cause for urticaria and this in turn helps in avoidance of possible causes and providing proper treatment<span lang="EN-IN">.</span></p>

scholarly journals SAT0415 AGE RELATIONSHIP WITH ULTRASOUND ARTICULAR AND ENTHESEAL INVOLVEMENT IN PSORIATIC ARTHRITIS: CROSS-SECTIONAL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1160.2-1161
Author(s):  
I. Fairushina ◽  
D. Abdulganieva ◽  
E. Kirillova ◽  
R. Abdrakipov
Keyword(s):  
Psoriatic Arthritis ◽  
Disease Activity ◽  
Power Doppler ◽  
Severity Index ◽  
Cross Sectional Study ◽  
Blood Biomarkers ◽  
Cross Sectional ◽  
Age Related ◽  
Hs Crp ◽  
Axial Involvement

Background:Detection of subclinical enthesitis and synovitis in psoriatic arthritis (PsA) is prevalent and ultrasound (US) examination is informative tool for it diagnosing. Aging positively affects degenerative changes.Objectives:To study relationship between US articular and entheseal findings with age in patients with PsA.Methods:57 patients were enrolled to study with fulfilled PsA criteria (CASPAR, 2009). Data collection: demographical, clinical (current psoriasis, axial involvement, enthesitis, dactylitis), US (synovitis count (by Grey Scale), Power Doppler(PD)+ synovitis), thickening and hypoechogenicity at enthesis, PD+ enthesitis, entheses with structural components); biological (high sensitive C-reactive protein (hsCRP), Erythrocyte Sedimentation Rate (ESR).US examination included 798 joints and 3078 entheses (bilateral shoulders, acromioclavicular joints, elbows, wrists, hips, knees, ankles; entheses at the projection of these joints (total number - 54). US entheseal findings were fixed according to consensus-based US definition and scoring for enthesitis in spondyloarthritis and PsA (OMERACT US)1.Results:In all 57 patients: male - 25 (43.9%), mean age 43.4±10.3(SD) years (y), PsA duration was 7 (3;10) y, Ps duration 10 (8; 22) y; 53 (41.1%) had axial involvement, 42 (73.7%) dactylitis, 8 (14%) clinical enthesitis, and 56 (98.2 %) skin psoriasis, Psoriasis Activity and Severity Index score 6.4 (2;14.4), Disease Activity in PsA score 18.1 (10.2;26.1), hsCRP 10.1(2.4;21.4), ESR 20 (11.3;31.5).Synovitis count increased with age noticeably (r=0.508, p<0.01), and weak correlation of PD+ synovitis (r=0.262, p=0.049) and age was found. The entheseal thickening and hypoechogenicity and structural findings increased with age respectively (r=0.345, p=0.009; r=0.337, p=0.01). There was no correlation between PD+ enthesitis and age. The assosiation between PD+ enthesitis and blood biomarkers of inflammation (hs-CRP (r=0.364, p=0.008); ESR (p=0.358, p=0.008) was found.Conclusion:Our study found significant relationship between age and US synovitis. Association between age and US entheseal involvement was noted. Only PD+ enthesitis was not related with age in comparison with other US entheseal findings. The presence of PD US signal at enthesitis in association with increased inflammatory blood biomarkers can be evaluated as the sign of disease activity regardless of age and not as age-related lesion in PsA patients.References:[1]Balint PV, Terslev L, Aegerter P et al. Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative. Ann Rheum Dis.;2018;77(12):1730-1735.Disclosure of Interests:None declared

Sign in / Sign up

Export Citation Format

Share Document