Light, Circadian Rhythms, and Mood Disorders: A Review

1992 ◽  
Vol 4 (2) ◽  
pp. 131-146 ◽  
Author(s):  
Michael Alan Hill
Keyword(s):  
Circadian Rhythms ◽  
Mood Disorders

Sleep and mood disorders: Relationship to circadian rhythms

1996 ◽  
Vol 6 ◽  
pp. 34
Author(s):  
T.A. Wehr ◽  
E. Leibenluft ◽  
P.J. Schwartz ◽  
E.H. Turner ◽  
N.E. Rosenthal
Keyword(s):  
Circadian Rhythms ◽  
Mood Disorders

scholarly journals Chronobiology and mood disorders

2003 ◽  
Vol 5 (4) ◽  
pp. 315-325 ◽  
Keyword(s):  
Circadian Rhythms ◽  
Sleep Deprivation ◽  
Mood Disorders ◽  
Seasonal Affective Disorder ◽  
Bright Light ◽  
Mood Stabilizers ◽  
Phase Advance ◽  
Diagnostic Systems ◽  
Recovery Sleep

The clinical observations of diurnal variation of mood and early morning awakening in depression have been incorporated into established diagnostic systems, as has the seasonal modifier defining winter depression (seasonal affective disorder, SAD). Many circadian rhythms measured in depressive patients are abnormal: earlier in timing, diminished in amplitude, or of greater variability. Whether these disturbances are of etiological significance for the role of circadian rhythms in mood disorders, or a consequence of altered behavior can only be dissected out with stringent protocols (eg, constant routine or forced desynchrony). These protocols quantify contributions of the circadian pacemaker and a homeostatic sleep process impacting on mood, energy, appetite, and sleep. Future studies will elucidate any allelic mutations in "circadian clock" -related or "sleep"-related genes in depression. With respect to treatment, antidepressants and mood stabilizers have no consistent effect on circadian rhythmicity. The most rapid antidepressant modality known so far is nonpharmacological: total or partial sleep deprivation in the second half of the night. The disadvantage of sleep deprivation, that most patients relapse after recovery sleep, can be prevented by coadministration of lithium, pindolol, serotonin (5-HT) reuptake inhibitors, bright light, or a subsequent phase-advance procedure. Phase advance of the sleep-wake cycle alone also has rapid effects on depressed mood, which lasts longer than sleep deprivation. Light is the treatment of choice for SAD and may prove to be useful for nonseasonal depression, alone or as an adjunct to medication. Chronobiological concepts emphasize the important role of zeitgebers to stabilize phase, light being the most important, but dark (and rest) periods, regularity of social schedules and meal times, and use of melatonin or its analogues should also be considered. Advances in chronobiology continue to contribute novel treatments for affective disorders.

Molecular Link between Circadian Rhythmicity and Mood Disorders

2021 ◽  
Vol 28 ◽  
Author(s):  
Frank Faltraco ◽  
Denise Palm ◽  
Andrew Coogan ◽  
Frederick Simon ◽  
Oliver Tucha ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Mood Disorders ◽  
Affective Disorders ◽  
Current Knowledge ◽  
Unipolar Depression ◽  
Internal Clock ◽  
Circadian Genes ◽  
Pubmed Database

Background: The internal clock is driven by circadian genes [e.g., Clock, Bmal1, Per1-3, Cry1-2], hormones [e.g., melatonin, cortisol], as well as zeitgeber [‘synchronisers’]. Chronic disturbances in the circadian rhythm in patients diagnosed with mood disorders have been recognised for more than 50 years. Objectives: The aim of this review is to summarise the current knowledge and literature regarding circadian rhythms in the context of mood disorders, focussing on the role of circadian genes, hormones, and neurotransmitters. Method: The review presents the current knowledge and literature regarding circadian rhythms in mood disorders using the Pubmed database. Articles with a focus on circadian rhythms and mood disorders [n=123], particularly from 1973 to 2020, were included. Results: The article suggests a molecular link between disruptions in the circadian rhythm and mood disorders. Circadian disturbances, caused by the dysregulation of circadian genes, hormones, and neurotransmitters, often result in a clinical picture resembling depression. Conclusion: Circadian rhythms are intrinsically linked to affective disorders, such as unipolar depression and bipolar disorder.

The social zeitgeber theory, circadian rhythms, and mood disorders: Review and evaluation

2006 ◽  
Vol 26 (6) ◽  
pp. 679-694 ◽  
Author(s):  
Louisa D. Grandin ◽  
Lauren B. Alloy ◽  
Lyn Y. Abramson
Keyword(s):  
Circadian Rhythms ◽  
Mood Disorders ◽  
The Social ◽  
Social Zeitgeber

6. Current controversies, future directions

2017 ◽  
Author(s):  
Mary Jane Tacchi ◽  
Jan Scott
Keyword(s):  
Immune System ◽  
Circadian Rhythms ◽  
Mood Disorders ◽  
Herbal Medicines ◽  
Alternative Therapies ◽  
Future Directions ◽  
Complementary And Alternative Therapies ◽  
The Mind ◽  
The Brain ◽  
Complementary And Alternative

Some people believe depression is massively over-diagnosed, some believe it to be an understandable reaction to life that should not be medicalized or treated, and some view depression as a diagnosable disorder but disagree with the treatments that should be offered. Is depression over-diagnosed? Do antidepressants work? Are all therapies equally effective for depression? ‘Current controversies, future directions’ explores these issues and looks at what evidence exists for the use of complementary and alternative therapies such as herbal medicines and exercise. It examines links between mood disorders and circadian rhythms and the immune system, and between research on the psychotherapy of the mind and the neuroscience of the brain.

Sign in / Sign up

Export Citation Format

Share Document