Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework

2014 ◽  
Vol 44 (5) ◽  
pp. 393-406 ◽  
Author(s):  
Mitscheli Sanches Da Rocha ◽  
Lora L. Arnold ◽  
Maria Luiza Cotrim Sartor De Oliveira ◽  
Shadia M. Ihlaseh Catalano ◽  
Ana Paula Ferragut Cardoso ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Mode Of Action ◽  
Chemical Safety ◽  
Rat Urinary Bladder ◽  
Bladder Carcinogenesis ◽  
International Programme

EFFECTS OF SIROLIMUS ON RAT URINARY BLADDER CARCINOGENESIS

2008 ◽  
Vol 7 (3) ◽  
pp. 211
Author(s):  
B. Parada ◽  
A. Figueiredo ◽  
F. Reis ◽  
P. Nunes ◽  
P. Eufrásio ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Bladder Carcinogenesis

scholarly journals Inhibitory Effect of Tomato Juice on Rat Urinary Bladder Carcinogenesis afterN-Butyl-N-(4-hydroxybutyl)nitrosamine Initiation

1998 ◽  
Vol 89 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Eijiro Okajima ◽  
Masahiro Tsutsumi ◽  
Seiichiro Ozono ◽  
Hiroyuki Akai ◽  
Ayumi Denda ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Inhibitory Effect ◽  
Tomato Juice ◽  
Rat Urinary Bladder ◽  
Bladder Carcinogenesis

scholarly journals Inhibitory Effect of Tomato Juice on Rat Urinary Bladder Carcinogenesis After N-Butyl-N-(4-hydroxybutyl)Nitrosamine Initiation

1998 ◽  
Vol 160 (5) ◽  
pp. 1930-1931
Author(s):  
E. Okajima ◽  
M. Tsutsumi ◽  
S. Ozono ◽  
H. Akai ◽  
A. Denda ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Inhibitory Effect ◽  
Tomato Juice ◽  
Rat Urinary Bladder ◽  
Bladder Carcinogenesis

Suppression of Rat Urinary Bladder Carcinogenesis by α-Difluoromethylornithine

1989 ◽  
Vol 141 (6) ◽  
pp. 1454-1457 ◽  
Author(s):  
Yukio Homma ◽  
Tadao Kakizoe ◽  
Shoji Samma ◽  
Ryoichi Oyasu
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Bladder Carcinogenesis

Severity of promotion by sodium salts of succinic acid in rat urinary bladder carcinogenesis correlates with sodium ion concentration under conditions of equal urinary pH

1993 ◽  
Vol 14 (11) ◽  
pp. 2277-2281 ◽  
Author(s):  
Tatsuyuki Otoshi ◽  
Hiroyuki Iwata ◽  
Shinji Yamamoto ◽  
Takashi Murai ◽  
Shuji Yamaguchi ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Succinic Acid ◽  
Sodium Ion ◽  
Ion Concentration ◽  
Urinary Ph ◽  
Rat Urinary Bladder ◽  
Sodium Salts ◽  
Bladder Carcinogenesis

Changes in aldehyde dehydrogenase during rat urinary bladder carcinogenesis

1989 ◽  
Vol 10 (11) ◽  
pp. 2081-2087 ◽  
Author(s):  
Peggy Campbell ◽  
Charles C. Irving ◽  
Ronald Lindahl
Keyword(s):  
Urinary Bladder ◽  
Aldehyde Dehydrogenase ◽  
Rat Urinary Bladder ◽  
Bladder Carcinogenesis

scholarly journals Rat Urinary Bladder Carcinogenesis by Dual-Acting PPARα+γAgonists

PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-14 ◽  
Author(s):  
Martin B. Oleksiewicz ◽  
Jennifer Southgate ◽  
Lars Iversen ◽  
Frederikke L. Egerod
Keyword(s):  
Urinary Bladder ◽  
Mode Of Action ◽  
Carcinogenic Effect ◽  
Attrition Rates ◽  
Rat Urinary Bladder ◽  
Mediated Effects ◽  
Kidney Pelvis ◽  
Rats And Mice

Despite clinical promise, dual-acting activators of PPARαandγ(here termed PPARα+γagonists) have experienced high attrition rates in preclinical and early clinical development, due to toxicity. In some cases, discontinuation was due to carcinogenic effect in the rat urothelium, the epithelial layer lining the urinary bladder, ureters, and kidney pelvis. Chronic pharmacological activation of PPARαis invariably associated with cancer in rats and mice. Chronic pharmacological activation of PPARγcan in some cases also cause cancer in rats and mice. Urothelial cells coexpress PPARαas well as PPARγ, making it plausible that the urothelial carcinogenicity of PPARα+γagonists may be caused by receptor-mediated effects (exaggerated pharmacology). Based on previously published mode of action data for the PPARα+γagonist ragaglitazar, and the available literature about the role of PPARαandγin rodent carcinogenesis, we propose a mode of action hypothesis for the carcinogenic effect of PPARα+γagonists in the rat urothelium, which combines receptor-mediated and off-target cytotoxic effects. The proposed mode of action hypothesis is being explored in our laboratories, towards understanding the human relevance of the rat cancer findings, and developing rapid in vitro or short-term in vivo screening approaches to faciliate development of new dual-acting PPAR agonist compounds.

Simultaneous Treatment With Benzyl Isothiocyanate, a Strong Bladder Promoter, Inhibits Rat Urinary Bladder Carcinogenesis by N-Butyl-N-(4-Hydroxybutyl)Nitrosamine

2002 ◽  
Vol 42 (2) ◽  
pp. 211-216 ◽  
Author(s):  
Kazushi Okazaki ◽  
Megumi Yamagishi ◽  
Hwa-Young Son ◽  
Takayoshi Imazawa ◽  
Fumio Furukawa ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Simultaneous Treatment ◽  
Benzyl Isothiocyanate ◽  
Rat Urinary Bladder ◽  
Bladder Carcinogenesis
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