Chronic lymphocytic leukemia, autoimmune hemolytic anemia and ibrutinib: a case report and review of the literature

2015 ◽  
Vol 57 (3) ◽  
pp. 735-737 ◽  
Author(s):  
Stefano Molica ◽  
Luciano Levato ◽  
Rosanna Mirabelli
2019 ◽  
Vol 12 ◽  
pp. 1179545X1989457
Author(s):  
Tahseen Hamamyh ◽  
Mohamed A Yassin

Autoimmune hemolytic anemia is one of the differential diagnoses for anemia in patients with lymphoproliferative neoplasia, such as chronic lymphocytic leukemia, who experience sudden drop in hemoglobin. The association between autoimmune hemolytic anemia and chronic myeloid leukemia on the contrary is unusual. Here we present a patient with a background of chronic myeloid leukemia treated previously with Tyrosine Kinase Inhibitors, then developed autoimmune hemolysis simultaneously with chronic myeloid leukemia relapse. Hemolysis was treated with steroids with good response.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Martino E ◽  
◽  
Vigna E ◽  
Mendicino F ◽  
Caracciolo D ◽  
...  

CLL is frequently complicated by autoimmune phenomena (up to 25% of patients) which are sustained by dysfunctions of the immune system. AIHA results the commonest form. In the past decade small molecules had dramatically change the therapeutic scenario of CLL. Their role in the setting of autoimmune phenomena has to be still elucidated. Here we report the case of a CLL patient harboring del (17p) in relapse of disease during ibrutinib therapy who experienced AIHA. Patient, refractory to steroids, achieved benefit from the administration of rituximab and venetoclax. The patient reached stable and long-lasting stabilization of hemoglobin values.


1996 ◽  
Vol 38 (4) ◽  
pp. 359-360 ◽  
Author(s):  
G. Tertian ◽  
J. Cartron ◽  
C. Bayle ◽  
A. Rudent ◽  
T. Lambert ◽  
...  

2018 ◽  
Vol 12 (1) ◽  
pp. 99-102 ◽  
Author(s):  
Utku Iltar ◽  
Vedat Aslan ◽  
Mesut Gocer ◽  
Fatma Aykac ◽  
İlknur Nizam ◽  
...  

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