Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging

2012 ◽  
Vol 18 (6) ◽  
pp. 1407-1416 ◽  
Author(s):  
Sarah Gordon ◽  
Kaisa Naelapää ◽  
Jukka Rantanen ◽  
Arzu Selen ◽  
Anette Müllertz ◽  
...  
Keyword(s):  
Real Time ◽  
Dissolution Behavior ◽  
Biorelevant Media ◽  
Uv Imaging

Real-time UV imaging identifies the role of pH in insulin dissolution behavior in hydrogel-based subcutaneous tissue surrogate

2015 ◽  
Vol 69 ◽  
pp. 26-36 ◽  
Author(s):  
Sabrine S. Jensen ◽  
Henrik Jensen ◽  
Claus Cornett ◽  
Eva H. Møller ◽  
Jesper Østergaard
Keyword(s):  
Real Time ◽  
Subcutaneous Tissue ◽  
Dissolution Behavior ◽  
Uv Imaging

scholarly journals Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 618
Author(s):  
Hakyeong Kim ◽  
Soeun Jang ◽  
Il Won Kim
Keyword(s):  
Model System ◽  
Dissolution Behavior ◽  
Active Pharmaceutical Ingredients ◽  
Biorelevant Media ◽  
Biologically Relevant ◽  
Pharmaceutical Ingredients ◽  
Enhanced Dissolution ◽  
Dissolution Properties ◽  
Eutectic Formation ◽  
Combined Strategy

Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs. Cocrystal formation is one of the methods to alter the physicochemical properties of APIs, but its dissolution behavior in biorelevant media has been scrutinized only in recent years. We investigated the combined strategy of cocrystallization and eutectic formation in this regard and utilized the cocrystal model system of naproxen and three pyridinecarboxamide isomers. Binary melting diagrams were constructed to discover the eutectic compositions of the three cocrystals with excess amounts of pyridinecarboxamides. The melt–crystallized eutectics and cocrystals were compared in their dissolution behaviors with respect to neat naproxen. The eutectics enhanced the early dissolution rates of the cocrystals in both the absence and presence of biologically relevant bile salt and phospholipid components, whereas the cocrystal dissolution was expedited and delayed, respectively. The combined strategy in the present study will be advantageous in maximizing the utility of the pharmaceutical cocrystals.

Insulin diffusion and self-association characterized by real-time UV imaging and Taylor dispersion analysis

2014 ◽  
Vol 92 ◽  
pp. 203-210 ◽  
Author(s):  
Sabrine S. Jensen ◽  
Henrik Jensen ◽  
Claus Cornett ◽  
Eva H. Møller ◽  
Jesper Østergaard
Keyword(s):  
Real Time ◽  
Taylor Dispersion ◽  
Dispersion Analysis ◽  
Uv Imaging ◽  
Self Association

Real-time UV imaging of piroxicam diffusion and distribution from oil solutions into gels mimicking the subcutaneous matrix

2012 ◽  
Vol 46 (1-2) ◽  
pp. 72-78 ◽  
Author(s):  
Fengbin Ye ◽  
Susan Weng Larsen ◽  
Anan Yaghmur ◽  
Henrik Jensen ◽  
Claus Larsen ◽  
...  
Keyword(s):  
Real Time ◽  
Uv Imaging

scholarly journals Insights into Amlodipine Besilate Dissolution Behavior Using UV Imaging

2011 ◽  
Author(s):  
Johan Bøtker ◽  
Jesper Østergaard ◽  
Jukka Rantanen ◽  
Claus Cornett ◽  
Anette Müllertz ◽  
...  
Keyword(s):  
Dissolution Behavior ◽  
Uv Imaging

Real-time UV imaging of drug diffusion and release from Pluronic F127 hydrogels

2011 ◽  
Vol 43 (4) ◽  
pp. 236-243 ◽  
Author(s):  
Fengbin Ye ◽  
Anan Yaghmur ◽  
Henrik Jensen ◽  
Susan W. Larsen ◽  
Claus Larsen ◽  
...  
Keyword(s):  
Real Time ◽  
Pluronic F127 ◽  
Drug Diffusion ◽  
Uv Imaging

Real-Time UV Imaging of Nicotine Release from Transdermal Patch

2010 ◽  
Vol 27 (12) ◽  
pp. 2614-2623 ◽  
Author(s):  
Jesper Østergaard ◽  
Emil Meng-Lund ◽  
Susan Weng Larsen ◽  
Claus Larsen ◽  
Karsten Petersson ◽  
...  
Keyword(s):  
Real Time ◽  
Transdermal Patch ◽  
Uv Imaging

Real-time in vitro dissolution of 5-aminosalicylic acid from single ethyl cellulose coated extrudates studied by UV imaging

2013 ◽  
Vol 83 ◽  
pp. 49-56 ◽  
Author(s):  
Mette Høg Gaunø ◽  
Thomas Vilhelmsen ◽  
Crilles Casper Larsen ◽  
Johan Peter Boetker ◽  
Jørgen Wittendorff ◽  
...  
Keyword(s):  
Real Time ◽  
Ethyl Cellulose ◽  
In Vitro Dissolution ◽  
Aminosalicylic Acid ◽  
Uv Imaging

Real-time observation of the interface between SiC and a liquid alloy and its application to the dissolution behavior of SiC at 1573 K

2013 ◽  
Vol 114 (21) ◽  
pp. 214313 ◽  
Author(s):  
Sakiko Kawanishi ◽  
Takeshi Yoshikawa ◽  
Kazuki Morita ◽  
Kazuhiko Kusunoki ◽  
Kazuhito Kamei ◽  
...  
Keyword(s):  
Real Time ◽  
Liquid Alloy ◽  
Dissolution Behavior ◽  
Time Observation ◽  
Real Time Observation
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