Effect of addition of paclitaxel on radiotherapy delivery and locoregional control of node positive breast cancer: Cancer and Leukemia Group B 9344

2005 ◽  
Vol 5 (1) ◽  
pp. 61-62
Author(s):  
Bruce G Haffty
Keyword(s):  
Breast Cancer ◽  
Locoregional Control ◽  
Node Positive ◽  
Group B ◽  
Leukemia Group ◽  
Positive Breast Cancer

Effect of Addition of Adjuvant Paclitaxel on Radiotherapy Delivery and Locoregional Control of Node-Positive Breast Cancer: Cancer and Leukemia Group B 9344

2005 ◽  
Vol 23 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Carolyn I. Sartor ◽  
Bercedis L. Peterson ◽  
Susan Woolf ◽  
Thomas J. FitzGerald ◽  
Frances Laurie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cumulative Incidence ◽  
Treatment Interruption ◽  
Breast Conserving Surgery ◽  
Locoregional Control ◽  
Node Positive ◽  
Group B ◽  
To Receive ◽  
Leukemia Group ◽  
Positive Breast Cancer

Purpose We compared radiotherapy (RT) delivery and locoregional control in patients with node-positive breast cancer randomly assigned on Cancer and Leukemia Group B 9344 to receive adjuvant doxorubicin/cyclophosphamide (AC) with patients assigned to receive AC followed by paclitaxel (AC+T). Methods Eligible patients were randomly assigned to receive adjuvant AC versus AC+T chemotherapy. RT was required if breast-conserving surgery was performed but was elective after mastectomy. Information about RT delivery was retrospectively collected. Cumulative incidence of locoregional recurrence (LRR), use of elective RT, and RT delivery were compared between treatment arms. Results For patients treated with breast-conserving surgery and RT, the 5-year cumulative incidence of isolated LRR was 9.7% in the AC arm and 3.7% in the AC+T arm (P = .04) and of LRR as any component of failure was 12.9% versus 6.1%, respectively (P = .04). Although LRR rates in patients who did not receive postmastectomy RT were lower in the AC+T arm, the difference was not statistically significant. Despite the lack of protocol guidelines, RT use did not differ between arms, nor did RT dose, treatment interruption, or completion. Conclusion Despite the delay to RT during additional chemotherapy, adjuvant AC+T afforded better local control than AC alone in patients treated with breast-conserving therapy. Addition of paclitaxel did not adversely affect delivery or ability to tolerate RT, as indicated by similar rates of completion of timely, full-dose RT between arms.

scholarly journals p53 Expression in Node-Positive Breast Cancer Patients: Results from the Cancer and Leukemia Group B 9344 Trial (159905)

2011 ◽  
Vol 17 (15) ◽  
pp. 5170-5178 ◽  
Author(s):  
Jonathan F. Lara ◽  
Ann D. Thor ◽  
Lynn G. Dressler ◽  
Gloria Broadwater ◽  
Ira J. Bleiweiss ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
P53 Expression ◽  
Node Positive ◽  
Group B ◽  
Leukemia Group ◽  
Positive Breast Cancer

Flow cytometry in node-positive breast cancer: Cancer and leukemia group B protocol 8869

Cytometry ◽  
1995 ◽  
Vol 22 (4) ◽  
pp. 297-306 ◽  
Author(s):  
Timothy E. Kute ◽  
Yasmeen Quadri ◽  
Hyman Muss ◽  
Nora Zbieranski ◽  
Constance Cirrincione ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Flow Cytometry ◽  
Node Positive ◽  
Group B ◽  
Leukemia Group ◽  
Positive Breast Cancer

Association of Angiogenesis and Disease Outcome in Node-Positive Breast Cancer Patients Treated With Adjuvant Cyclophosphamide, Doxorubicin, and Fluorouracil: A Cancer and Leukemia Group B Correlative Science Study From Protocols 8541/8869

2002 ◽  
Vol 20 (3) ◽  
pp. 732-742 ◽  
Author(s):  
Anthony J. Guidi ◽  
Donald A. Berry ◽  
Gloria Broadwater ◽  
Birgit Helmchen ◽  
Ira J. Bleiweiss ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Univariate Analysis ◽  
Dose Schedule ◽  
Vascular Pattern ◽  
Breast Cancer Patients ◽  
Node Positive ◽  
Group B ◽  
Leukemia Group ◽  
Positive Breast Cancer

PURPOSE: Increased microvessel density (MVD), a reflection of tumor angiogenesis, is associated with diminished relapse-free and overall survival (OS) in several subsets of breast cancer patients. However, the utility of this assay in node-positive patients treated with adjuvant cyclophosphamide, doxorubicin, and fluorouracil (CAF) has not been well studied. PATIENTS AND METHODS: Immunostaining for factor VIII–related antigen was performed on tissue sections from a subset of node-positive patients who received one of three dose/schedule regimens of CAF during participation in Cancer and Leukemia Group B protocol 8541. Sections from 577 cancers exhibited acceptable tumor and immunostaining quality and were included in the study. Each section was examined quantitatively for MVD as well as nonquantitatively by scoring the presence or absence of a prominent vascular pattern. RESULTS: MVD counts were not associated with relapse-free or OS in univariate analysis. The presence of a prominent plexiform vascular pattern was correlated with decreased OS (P = .0085) in univariate analysis, but this pattern was not an independent prognostic indicator of survival in multivariate analysis. No apparent clinically important interactions between measures of angiogenesis, other prognostic factors, administration of tamoxifen, and chemotherapy dose were observed. CONCLUSION: Assessment of angiogenesis does not provide useful information regarding prognosis in node-positive breast cancer patients treated with adjuvant CAF, nor do these measures predict which patients will benefit from dose intensification or addition of tamoxifen.

Weight gain after adjuvant TAC (docetaxel, doxorubicin, and cyclophosphamide) chemotherapy for node-positive breast cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11552-e11552
Author(s):  
Y. Suh ◽  
S. Oh ◽  
B. Song ◽  
S. Jung
Keyword(s):  
Breast Cancer ◽  
Weight Gain ◽  
Adjuvant Chemotherapy ◽  
Randomized Trials ◽  
Fluid Retention ◽  
Node Positive ◽  
Tac Chemotherapy ◽  
Group A ◽  
Group B ◽  
Positive Breast Cancer

e11552 Background: Despite of its proven therapeutic efficacy, TAC (docetaxel, Doxorubicin and cyclophosphamide) regimen as an adjuvant chemotherapy has some serious adverse effects such as fluid retention and neutropenia. Even though dexamethasone is known to be given for three days to the patients having TAC chemotherapy to prevent severe fluid retention, most patients have ironically been complaining of much weight gain more than 15% increase after the use of dexamethasone. We tried to determine abbreviated use of dexamethasone is better to decrease the extent of weight gain after TAC chemotherapy. Methods: Eighty node-positive patients between Jan. 2006 and Oct. 2007 were randomly assigned either into 24-hr (group A: 10 mg dexamethasone the night before TAC, and 10 mg dexamethasone (bid) were given for the day 1) or 72-hr dexamethasone premedication (group B) only after getting informed consent since all the protocols were reviewed by IRB. We compared the incidence of severe weight gain (more than 15%) on completion of six cycles in two groups. No patient was found to have heart or kidney problem before the commencement of chemotherapy. Results: Each group was comprised of 40 patients. All patients underwent 6 cycles. Mean age of each group was 48.5 (A) and 50.3 (B) years. The incidence of severe weight gain was 47.3 % in Group A, and 78.4 % in Group B. There was no difference in the duration of recovering from weight gain in both groups (A: 6.52 months vs. B: 7.02 months). No other hematologic complications seemed different between two groups. Conclusions: Though larger scale prosepctive randomized trials should be required to get the definitive conclusion on this matter, we think that current dexamethasone premedication may aggravate weight gain than to prevent it. If shorter schedule is as much effective as longer one, abbreviated and reduced dexamethasone premedication is more helpful for patients having TAC chemotherapy. No significant financial relationships to disclose.

Randomized Trial of Dose-Dense Versus Conventionally Scheduled and Sequential Versus Concurrent Combination Chemotherapy as Postoperative Adjuvant Treatment of Node-Positive Primary Breast Cancer: First Report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741

2003 ◽  
Vol 21 (8) ◽  
pp. 1431-1439 ◽  
Author(s):  
Marc L. Citron ◽  
Donald A. Berry ◽  
Constance Cirrincione ◽  
Clifford Hudis ◽  
Eric P. Winer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Concurrent Chemotherapy ◽  
Axillary Node ◽  
Severe Neutropenia ◽  
Node Positive ◽  
Dose Dense ◽  
Group B ◽  
To Receive ◽  
Leukemia Group

Purpose: Using a 2 × 2 factorial design, we studied the adjuvant chemotherapy of women with axillary node–positive breast cancer to compare sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) with concurrent doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T) for disease-free (DFS) and overall survival (OS); to determine whether the dose density of the agents improves DFS and OS; and to compare toxicities. Patients and Methods: A total of 2,005 female patients were randomly assigned to receive one of the following regimens: (I) sequential A × 4 (doses) → T × 4 → C × 4 with doses every 3 weeks, (II) sequential A × 4 → T × 4 → C × 4 every 2 weeks with filgrastim, (III) concurrent AC × 4 → T × 4 every 3 weeks, or (IV) concurrent AC × 4 → T × 4 every 2 weeks with filgrastim. Results: A protocol-specified analysis was performed at a median follow-up of 36 months: 315 patients had experienced relapse or died, compared with 515 expected treatment failures. Dose-dense treatment improved the primary end point, DFS (risk ratio [RR] = 0.74; P = .010), and OS (RR = 0.69; P = .013). Four-year DFS was 82% for the dose-dense regimens and 75% for the others. There was no difference in either DFS or OS between the concurrent and sequential schedules. There was no interaction between density and sequence. Severe neutropenia was less frequent in patients who received the dose-dense regimens. Conclusion: Dose density improves clinical outcomes significantly, despite the lower than expected number of events at this time. Sequential chemotherapy is as effective as concurrent chemotherapy.

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