Metal fume fever and polymer fume fever

Occupational asthma and rhinitis 198Latex allergy 202Byssinosis 205Organic dust toxic syndrome 205Hypersensitivity pneumonitis 206Humidifier fever 208Metal fume fever 210Chronic obstructive pulmonary disease 212Asbestos-related diseases 214The pneumoconioses 216Coal worker’s pneumoconiosis 218Asbestosis 220Silicosis 222Berylliosis ...

Download Full-text

An Experimental Human Model of Metal Fume Fever

Annals of Internal Medicine ◽

10.7326/0003-4819-114-11-930 ◽

1991 ◽

Vol 114 (11) ◽

pp. 930 ◽

Cited By ~ 58

Author(s):

Paul Blanc

Keyword(s):

Human Model ◽

Metal Fume Fever

Download Full-text

Metal fume fever

European Journal of Emergency Medicine ◽

10.1097/00063110-199812000-00015 ◽

1998 ◽

Vol 5 (4) ◽

pp. 465???466

Author(s):

D. VAN PEE ◽

O. VANDENPLAS ◽

J. B. GILLET

Keyword(s):

Metal Fume Fever

Download Full-text

Novel aspect on metal fume fever: zinc stimulates oxygen radical formation in human neutrophils

Human & Experimental Toxicology ◽

10.1177/096032719801700205 ◽

1998 ◽

Vol 17 (2) ◽

pp. 105-110 ◽

Cited By ~ 22

Author(s):

Mats Lindahl ◽

Per Leanderson ◽

Christer Tagesson

Keyword(s):

Metal Ions ◽

Phorbol Myristate Acetate ◽

Oxygen Radicals ◽

Fold Increase ◽

Oxygen Radical ◽

Radical Formation ◽

Human Neutrophils ◽

Myristate Acetate ◽

Acute Reaction ◽

Metal Fume Fever

Exposure to zinc fume may cause metal fume fever, an acute reaction characterized by an invasion of neutrophils into the airways. This investigation was conducted to examine the possibility that Zn2+ and ZnO might stimulate the formation of oxygen radicals by human neutrophils. Luminol-amplified chemiluminescence (CL) was monitored during 2 h from human neutrophils exposed to Zn2+or ZnO. The response was compared to that of other metal ions and to that of endotoxin and phorbol myristate acetate (PMA). Zn2+ (6-50 mM) gradually caused a 2-6-fold increase of CL that reached an optimum after 70-80 min. By contrast, Cd2+, Cr2+, Cr3+, Fe2+, Fe3+, Ni2+ or Co2+ in corresponding concentrations did not increase the CL. Similar to Zn2+, endotoxin (40-640 mg/ml) caused a 2-5-fold increase of CL with an optimum after 70 min, and endotoxin (40 mg/ml) together with Zn2+ (50 mM) synergistically increased the CL. ZnO (12-100 mg/ml) also augmented CL, with a 1.5-5-fold increase at 25-100 mg/ ml ZnO but with a time response similar to that found after PMA stimulation, in which CL peaked after 20-40 min incubation. Both Zn2+- and ZnO-induced CL was inhibited by manoalide, a phospholipase A2 inhibitor, with IC50 of 0.25 mM and 0.66 mM respectively. These results indicate that Zn2+ and ZnO both stimulates oxygen radical formation in human neutrophils and that this might contribute to the pathogenesis of zinc fume fever.

Download Full-text