Body distribution of SiO2–Fe3O4core-shell nanoparticles after intravenous injection and intratracheal instillation

2015 ◽  
Vol 10 (5) ◽  
pp. 567-574 ◽  
Author(s):  
Stijn Smulders ◽  
Ashwini Ketkar-Atre ◽  
Katrien Luyts ◽  
Hanne Vriens ◽  
Sonia De Sousa Nobre ◽  
...  
Keyword(s):  
Intravenous Injection ◽  
Intratracheal Instillation ◽  
Shell Nanoparticles ◽  
Body Distribution

Whole-body distribution of 14C-labeled silica nanoparticles and submicron particles after intravenous injection into Mice

2012 ◽  
Vol 14 (5) ◽  
Author(s):  
Nobumitsu Sakai ◽  
Masato Takakura ◽  
Harutoshi Imamura ◽  
Miki Sugimoto ◽  
Yasuto Matsui ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Intravenous Injection ◽  
Submicron Particles ◽  
Whole Body ◽  
Body Distribution

Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection

Biomaterials ◽  
2010 ◽  
Vol 31 (25) ◽  
pp. 6574-6581 ◽  
Author(s):  
Jens Lipka ◽  
Manuela Semmler-Behnke ◽  
Ralph A. Sperling ◽  
Alexander Wenk ◽  
Shinji Takenaka ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Intravenous Injection ◽  
Intratracheal Instillation

Reactivity of Pulmonary Alveolar Cells to Crocidolite Asbestos Fibers

1982 ◽  
Vol 40 ◽  
pp. 334-335
Author(s):  
Charles L. Sanders ◽  
Roy R. Adee
Keyword(s):  
Osmium Tetroxide ◽  
Intratracheal Instillation ◽  
Uranyl Acetate ◽  
Fiber Suspension ◽  
Nacl Solution ◽  
Alveolar Cells ◽  
Asbestos Fibers ◽  
Fischer Rats ◽  
Mineral Silicates

Asbestos is a generic name for a group of hydrated mineral silicates that occur naturally in a fibrous form. The early interactions of asbestos fibers with alveolar cells in large part determines their long-term toxicity. Young adult, SPF, Fischer rats were given a single intratracheal instillation of 2 mg crocidolite asbestos suspended in 0.5 ml of 0.9% NaCl solution. About 80% of the fibers had lengths of less than 10 ym as measured on light micrographs of the fiber suspension. Two rats were killed at 3 hr, 1 d and 1, 4, 8, 12 and 16 wk after instillation and the lungs instilled with 8 ml McDowell - Trumps at 20 cm H2O. Lung tissue was dehydrated and sputtered coated with palladium-gold for SEM or post-fixed in osmium tetroxide, embedded in epoxy resin and sections stained with uranyl acetate and lead citrate for TEM.

Ultrastructure of rat alveolar macrophages activated in situ by poly:IC

1987 ◽  
Vol 45 ◽  
pp. 768-769
Author(s):  
A. M. Klinkner ◽  
R. A. Weiss ◽  
A. Kelley ◽  
P. J. Bugelski
Keyword(s):  
Venous Blood ◽  
Intratracheal Instillation ◽  
Buffy Coat ◽  
Fischer 344 Rats ◽  
Blood Monocytes ◽  
Fischer 344 ◽  
Polyinosinic:Polycytidylic Acid ◽  
Macrophage Activator ◽  
Endogenous Peroxidase

Polyinosinic:polycytidylic acid is an inducer of interferon and a macrophage activator. We have found that intratracheal instillation of polyI:C (IT-pI:C) activates rat bronchoalveolar lavage cells (BAL) for a variety of functions. Examination of Giemsa stained, cytocentrifuge preparations showed that IT-pI:C induced a population of BAL not seen in resident BAL. The morphology of these cells suggested that they might be derived from blood monocytes. To test this hypothesis we have examined several populations of macrophages that had been stained for endogenous peroxidase activity as a marker of cells derived from the monocyte-macrophage lineage.Macrophages were obtained from Fischer 344 rats. Peritoneal exudate cells (PEC) were collected by lavage 4 days after i.p. injection of 20 ml 3% thioglycolate. Buffy coat monocytes were separated from venous blood from naive rats.

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