Application of Pharmacokinetics and Pharmacodynamics in Antimicrobial Global Drug Development

2007 ◽  
pp. 445-460
Keyword(s):  
Drug Development ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Global Drug Development

Diosgenin: Therapeutic Action, Pharmacology and Applications

2017 ◽  
Vol 5 (1) ◽  
pp. 7-15
Author(s):  
Sanasam Sanjeev ◽  
◽  
Maibam Sunita Devi ◽  
Khushboo Maurya ◽  
Vikas Kumar Roy ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Drug Development ◽  
Liver Diseases ◽  
Potential Role ◽  
Wide Spectrum ◽  
Herbal Product ◽  
Biological Properties ◽  
Therapeutic Action ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Beneficial Effects

Diosgenin [25R-spriost-5-en-3þ-ol], is an important steroidal metabolite found in various plant species. The discovery of diosgenin has made it one of the most researched and studied herbal product. Moreover, there is excellent opportunity to address whether diosgenin plays a role in chemoprevention versus therapy, or both. However, rigorous experimental based evidence in support of ethnomedicine-derived notions would lead to the development of products relevant to drug development. The health beneficial effects of diosgenin are further extended to its potential role to treat other ailments such as HIV and hepatitis-C infections as well as liver diseases. There is little information regarding the bioavailability, pharmacokinetics and pharmacodynamics of diosgenin in relation to its health beneficial effects. It has been reported to have wide spectrum of biological properties that contributes to several diseases in its role as a health beneficial phytochemical by citing new studies.

scholarly journals Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL review

2019 ◽  
Vol 71 (4) ◽  
pp. 699-723 ◽  
Author(s):  
Ioannis Loisios-Konstantinidis ◽  
Rafael L. M. Paraiso ◽  
Nikoletta Fotaki ◽  
Mark McAllister ◽  
Rodrigo Cristofoletti ◽  
...  
Keyword(s):  
Drug Development ◽  
Therapeutic Equivalence ◽  
Pharmacokinetics And Pharmacodynamics ◽  
The Relationship
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