Horizons of development of immunotherapy for malignant liver tumors

Primary liver tumors are one of the most common types of malignant neoplasms. Surgical excision is still the most effective treatment in the early stages of the disease, however in most cases early diagnosis is difficult. Moreover, even if the treatment is carried out according to a radical program, the risk of relapse remains extremely high. In this regard, the search for new strategies for the treatment of liver malignancies that differ from traditional methods of treatment is not terminated. One of such promising approaches is immunotherapy. The present review is devoted to the current understanding of the mechanisms of action and the available clinical experience in the use of immunotherapy approaches in the treatment of liver malignancies. Combining different types of immunotherapy or combining immunotherapy with traditional therapeutic approaches can facilitate a synergistic effect and contribute to the development of personalized medicine.

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Eight years after introducing liver resection at the Oncology Institute of Vojvodina

Archive of oncology ◽

10.2298/aoo1304101m ◽

2013 ◽

Vol 21 (3-4) ◽

pp. 101-104

Author(s):

Ivan Majdevac ◽

Nikola Budisin ◽

Milan Ranisavljevic ◽

Dejan Lukic ◽

Imre Lovas ◽

...

Keyword(s):

Colorectal Cancer ◽

Liver Resection ◽

Liver Tumors ◽

Liver Parenchyma ◽

Malignant Neoplasms ◽

Chemotherapy Treatment ◽

Primary Liver Tumors ◽

Cancer Metastases ◽

Colorectal Cancer Metastases ◽

Medical Histories

Background: Hepatectomies are mostly performed for the treatment of hepatic benign or malignant neoplasms, intrahepatic gallstones, or parasitic cysts of the liver. The most common malignant neoplasms of the liver are metastases from colorectal cancer. Anatomic liver resection involves two or more hepatic segments, while non-anatomic liver resection involves resection of the metastases with a margin of uninvolved tissue. The aim of this manuscript was to show results of hepatectomies performed at the Oncology Institute of Vojvodina. Methods: We performed 133 liver resections from January 1997 to December 2013. Clinical and histopathological data were obtained from operative protocols, histopathological reports, and patients? medical histories. Results: We did 80 metastasectomies, 51 segmentectomies, and 18 radiofrequent ablations (RFA). Average number of colorectal cancer metastases was 1.67 per patient. We also made 10 left hepatectomies. In all cases, we made non-anatomic resections. Conclusion: Decision about anatomic versus non-anatomic resections for colorectal metastasis and primary liver tumors should be made before surgical exploration. Preservation of liver parenchyma is important with respect to liver failure and postoperative chemotherapy treatment.

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Malignant Liver Tumors in Childhood

Cancer in Childhood ◽

10.1007/978-1-4684-2070-8_22 ◽

1973 ◽

pp. 166-170

Author(s):

Sigmund H. Ein ◽

Clinton A. Stephens

Keyword(s):

Liver Tumors ◽

Malignant Liver Tumors ◽

Malignant Liver

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Transarterial Therapies for Benign and Malignant Liver Tumors

Basics of Hepatobiliary Interventions ◽

10.1007/978-981-15-6856-5_12 ◽

2020 ◽

pp. 153-179

Author(s):

Suyash S. Kulkarni ◽

Nitin Sudhakar Shetty ◽

Shashank Mishra ◽

David Narayan

Keyword(s):

Liver Tumors ◽

Malignant Liver Tumors ◽

Malignant Liver

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Primary Hepatic Angiosarcoma: A Rare Liver Malignancy – Varying Manifestations but Grave Prognosis

Case Reports in Gastroenterology ◽

10.1159/000506928 ◽

2020 ◽

Vol 14 (1) ◽

pp. 137-149 ◽

Cited By ~ 1

Author(s):

Natthapat Rujeerapaiboon ◽

Panu Wetwittayakhlang

Keyword(s):

Liver Tumors ◽

Case Series ◽

High Rate ◽

Therapeutic Approaches ◽

Tumor Rupture ◽

Liver Malignancies ◽

Liver Malignancy ◽

Hepatic Angiosarcoma ◽

Clinical Presentations ◽

Primary Hepatic Angiosarcoma

Primary hepatic angiosarcoma (PHA) is a rare mesenchymal liver tumor, accounting for 0.1–2% of primary liver malignancies. The clinical presentations of PHA are variable, from asymptomatic to liver failure or complicated with tumor rupture. The diagnosis of PHA is difficult due to the lack of specific clinical manifestation and investigation results, which can be confused with other liver tumors resulting in late diagnosis. However, there is currently a paucity of effective therapeutic approaches. We advocate early diagnosis with radiological imaging and histopathology because most of them are diagnosed in late-stage and carry a grave prognosis. Surgical resection remains the mainstay of treatment, which can significantly prolong survival. Chemotherapy, including transarterial chemoembolization, is an option for palliative treatment. Unfortunately, molecular treatment has limited efficacy and liver transplantation is also not recommended due to high rate of recurrence. We present a case series of four patients with biopsy-proven PHA which had distinct presentations and clinical courses.

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