scholarly journals Sense and anti-sense transcripts at the PGM5 locus are differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Normal Ovary ◽  
Serous Ovarian Cancer ◽  
Primary Tumors

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). Here, we report significant differential sense and anti-sense transcription at the PGM locus in high-grade serous ovarian tumors.

scholarly journals MIR503HG is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Normal Ovary ◽  
Significant Differential Expression ◽  
Primary Tumors

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We found significant differential expression of MIR503HG in high-grade serous ovarian tumors.

scholarly journals Cytidine-5’-triphosphate synthase 1 (CTPS1) is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Normal Ovary ◽  
Significant Differential Expression ◽  
Primary Tumors

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We found significant differential expression of CTPS1 in high-grade serous ovarian tumors.

scholarly journals SYTL4 is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Normal Ovary ◽  
Significant Differential Expression ◽  
Primary Tumors

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We found significant differential expression of synaptotagmin-like 4 (SYTL4) in high-grade serous ovarian tumors.

scholarly journals RBPMS is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Normal Ovary ◽  
Significant Differential Expression ◽  
Primary Tumors

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We found significant differential expression of RBPMS in high-grade serous ovarian tumors.

scholarly journals HLF is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Normal Ovary ◽  
Significant Differential Expression ◽  
Primary Tumors

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We found significant differential expression of the transcription factor hepatic leukemia factor (4, 5) (HLF) in high-grade serous ovarian tumors.

scholarly journals Multiple members of the transcription factor elongation A like (TCEAL) family are differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Ovarian Cancers

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). Perturbed expression of TCEAL7 has previously been reported in epithelial ovarian cancers (4). Here we find significant differential expression of multiple members of the TCEAL gene family in high-grade serous ovarian tumors.

scholarly journals ASPM is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We found significant differential expression of the gene encoding ASPM in high-grade serous ovarian tumors.

scholarly journals Carboxypeptidase Z is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Microarray Data ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
Ovarian Tumors ◽  
High Grade ◽  
Normal Ovary ◽  
Serous Ovarian Cancer ◽  
Primary Tumors ◽  
Ovarian Cancers

We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (1, 2). We identified carboxypeptidase Z (CPZ) (3) as among the genes whose expression was most different in HGSC ovarian tumors. CPZ expression was significantly lower in ovarian tumors relative to normal ovary. CPZ may be relevant to the biology of high-grade serous ovarian cancers.

scholarly journals GADD45G is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Microarray Data ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We found significant differential expression of the gene encoding GADD45G in high-grade serous ovarian tumors.

scholarly journals CASP12 is differentially expressed in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
Ovarian Tumors ◽  
High Grade ◽  
Normal Ovary ◽  
Primary Tumors ◽  
Ovarian Cancers

Ovarian cancer is the most lethal gynecologic cancer (1). To identify genes associated with high-grade serous ovarian cancer (HGSC), we used published microarray data (2, 3) to compare global gene expression profiles of the normal ovary with that of primary tumors from women diagnosed with HGSC. We identified caspase-12 (CASP12) (4) as among the genes whose expression was most quantitatively different in HGSC ovarian tumors. CASP12 expression was decreased in ovarian tumors when compared to normal ovary. These data indicate that CASP12 might be relevant to the biology of high-grade serous ovarian cancers.

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