CASP12 is differentially expressed in high-grade serous ovarian cancers.
Keyword(s):
Ovarian cancer is the most lethal gynecologic cancer (1). To identify genes associated with high-grade serous ovarian cancer (HGSC), we used published microarray data (2, 3) to compare global gene expression profiles of the normal ovary with that of primary tumors from women diagnosed with HGSC. We identified caspase-12 (CASP12) (4) as among the genes whose expression was most quantitatively different in HGSC ovarian tumors. CASP12 expression was decreased in ovarian tumors when compared to normal ovary. These data indicate that CASP12 might be relevant to the biology of high-grade serous ovarian cancers.
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