The beta subunit of the Interleukin-10 receptor is differentially expressed in brain metastatic breast cancer.
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Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the beta subunit of the interleukin-10 receptor, encoded by IL10RB, in the brain metastases of patients with metastatic breast cancer. Signals transduced from the interleukin-10 receptor, and its immunosuppressive and/or tolerogenic properties (6-10) may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.
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