Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Surgical Intervention ◽  
Liver Volume ◽  
Sigmoid Colon Cancer ◽  
Remnant Liver ◽  
Future Remnant Liver ◽  
The Right ◽  
Synchronous Colorectal Liver Metastasis ◽  
Right Hepatic Vein

A 72-year-old woman with a sigmoid colon cancer anda synchronous colorectal liver metastasis (CRLM), whichinvolved the right hepatic vein (RHV) and the inferiorvena cava (IVC), was referred to our hospital. Themetastatic lesion was diagnosed as initially unresectablebecause of its invasion into the confluence of theRHV and IVC. After she had undergone laparoscopicsigmoidectomy for the original tumor, she consequentlyhad 3 courses of modified 5-fluorouracil, leucovorin,and oxaliplatin (mFOLFOX6) plus cetuximab. Computedtomography revealed a partial response, and theconfluence of the RHV and IVC got free from cancerinvasion. After 3 additional courses of mFOLFOX6 pluscetuximab, preoperative percutaneous transhepaticportal vein embolization (PTPE) was performed tosecure the future remnant liver volume. Finally, a righthemihepatectomy was performed. The postoperativecourse was uneventful. The patient was dischargedfrom the hospital on postoperative day 13. She hadneither local recurrence nor distant metastasis 18 moafter the last surgical intervention. This multidisciplinarystrategy, consisting of conversion chemotherapy usingFOLFOX plus cetuximab and PTPE, could contributein facilitating curative hepatic resection for initiallyunresectable CRLM.Key words: Initially unresectable; Colorectal liver metastasis;Conversion chemotherapy; Cetuximab; Percutaneoustranshepatic portal vein embolization

Simultaneous liver and colorectal resections are safe for synchronous colorectal liver metastasis

2003 ◽  
Vol 197 (2) ◽  
pp. 233-241 ◽  
Author(s):  
Robert Martin ◽  
Philip Paty ◽  
Yuman Fong ◽  
Andrew Grace ◽  
Alfred Cohen ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Synchronous Colorectal Liver Metastasis ◽  
Colorectal Resections

scholarly journals Synchronous colorectal liver metastasis managment: A single-cente analysis

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e179
Author(s):  
I. Talal ◽  
M. Serradilla ◽  
J.R. Oliver ◽  
C. Vallejo ◽  
C. Hörndler-Argarate ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Synchronous Colorectal Liver Metastasis

scholarly journals The liver-first approach for synchronous colorectal liver metastasis: outcomes of a ten-year experience

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S659
Author(s):  
M. de Jong ◽  
R. Beckers ◽  
V. van Woerden ◽  
J. Sijmon ◽  
C. Dejong
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Synchronous Colorectal Liver Metastasis

Preoperative Chemotherapy May Not Influence the Remnant Liver Regenerations and Outcomes After Hepatectomy for Colorectal Liver Metastasis

2018 ◽  
Vol 42 (10) ◽  
pp. 3316-3330 ◽  
Author(s):  
Yoshihiro Inoue ◽  
Kensuke Fujii ◽  
Keitaro Tashiro ◽  
Masatsugu Ishii ◽  
Shinsuke Masubuchi ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastasis ◽  
Remnant Liver

scholarly journals Right hepatectomy with preservation of the entire caudate lobe in patients with metastatic liver tumors: a case of a new hepatectomy technique and treatment strategy for patients with marginal liver function

BMC Surgery ◽  
2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Hiroyuki Kato ◽  
Yukio Asano ◽  
Masahiro Ito ◽  
Satoshi Arakawa ◽  
Norihiko Kawabe ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Indocyanine Green ◽  
Liver Volume ◽  
Caudate Lobe ◽  
Remnant Liver ◽  
Right Hepatectomy ◽  
Indocyanine Green Clearance ◽  
The Right ◽  
Metastatic Liver

Abstract Background Performing major hepatectomy for patients with marginal hepatic function is challenging. In some cases, the procedure is contraindicated owing to the threat of postoperative liver failure. In this case report, we present the first case of marginal liver function (indocyanine green clearance retention rate at 15 min [ICGR15]: 28%) successfully treated with right hepatectomy, resulting in total caudate lobe preservation. Case presentation A 71-year-old man was diagnosed with sigmoid colon cancer with three liver metastases (S5, S7, and S8). All of metastatic lesions shrunk after chemotherapy, but his ICGR15 and indocyanine green clearance rate (ICGK) were 21% and 0.12, respectively. Moreover, the remnant liver volume was only 39%. Therefore, portal venous embolism (PVE) of the right portal vein was suggested. Portography showed divergence of the considerably preserved right caudate lobe branch (PV1R) from the root of the right portal vein. The liver function was reevaluated 18 days after PVE was suggested. During this time, the ICGR15 (21–28%) and ICGK rate (0.12–0.10) deteriorated. The right caudate lobe was significantly enlarged; thus, a total caudate lobe-preserving hepatectomy (TCPRx) was performed. Patients eligible for TCPRx included those with (1) hepatocellular carcinoma or metastatic liver cancer, (2) no tumor in the caudate lobe, (3) marginal liver function (ICG Krem greater than 0.05 if TCPRx was adapted; otherwise, less than 0.05) and Child–Pugh classification category A, and (4) preserved PV1R and right caudate bile duct branch. The procedure was performed through (A) precise estimation of the remnant liver volume preoperatively, (B) repeated intraoperative cholangiography to confirm the biliary branch of the right caudate lobe (B1R) conservation, and (C) stapler division of posterior and anterior Glisson’s pedicles laterally to avoid injuries to the PV1R and B1R. Conclusions Right hepatectomy with total caudate lobe preservation, following PVE, was a safe and viable surgical technique for patients with marginal liver function.

scholarly journals Tumor response and outcome after reverse treatment for patients with synchronous colorectal liver metastasis: a cohort study

BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Céline Du Pasquier ◽  
Didier Roulin ◽  
Pierre Bize ◽  
Christine Sempoux ◽  
Caterina Rebecchini ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Tumor Response ◽  
Synchronous Colorectal Liver Metastasis
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